Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma in patients with metastatic disease.Researchers from Dana-Farber Cancer Institute report a response rate of 24 percent across all risk categories of patients given an oral first-in-class agent that targets hypoxia inducible factor (HIF) 2-a, which promotes new blood vessel growth that fuels kidney tumors.Based on these findings, a phase III trial has been launched.“A new drug [MK-6482] as a single agent showing an overall response rate of 24 percent across all risk categories — poor, intermediate, and good, and in a heavily refractory population — is quite promising,” said Toni Choueiri, first author of the abstract. Choueiri is director of the Lank Center for Genitourinary Oncology and the Jerome and Nancy Kohlberg Professor of Medicine at Harvard Medical School.The drug targets a component of the body’s mechanism for sensing oxygen levels and turning on genes that enable the body to adjust to hypoxia — a shortage of oxygen — by making more red blood cells and forming new blood vessels. Dana-Farber scientist and Choueiri’s mentor and collaborator William G. Kaelin Jr. shared the 2019 Nobel Prize in medicine with two other researchers for unraveling this complex mechanism, which can be hijacked by cancer to help tumors survive and grow.In the vast majority of patients with clear cell renal carcinoma, a tumor suppressor protein known as Von Hippel-Lindau (VHL) is not functional. As a result, HIF proteins accumulate inside the tumor cell, wrongly signaling a shortage of oxygen, and activating the formation of blood vessels, fueling tumor growth. Understanding this abnormal process has paved the way for new cancer drugs. MK-6482 is one of them, and is distinct in that it targets HIF-2a directly, leading to blocking cancer cell growth, proliferation, and abnormal blood vessel formation.The study of MK-6482 included 55 patients with advanced clear cell kidney cancer who had an average of three prior lines of therapies.After a median follow-up period of 13 months, the overall response rate was 24 percent. Forty-one patients had stable disease with a disease control rate (complete response plus partial response plus stable disease) of 80 percent. There were partial responses in two of five favorable-risk patients; 10 of 40 intermediate-risk patients; and one of 10 poor-risk patients.The median duration of response had not been reached: 81 percent of patients had an estimated response of more than six months, and 16 patients continued treatment beyond 12 months. The median progression-free response rate was 11 months.The presentation (Abstract 611) is scheduled for Oral Abstract Session C: Renal Cell Cancer on Saturday at the ASCO 2020 Genitourinary Cancers Symposium in the Moscone West Building, San Francisco.Choueiri has pending patents for biomarkers of immune checkpoint blockers. Choueiri’s disclosures include grants, personal fees, or nonfinancial support from Agensys, Alexion, Alligent, Analysis Group, AstraZeneca, Bayer, Bristol-Myers Squibb, Calithera, Cerulean, Clinical Care Options, Corvus, Eli Lilly, Esai, Exelixis, Foundation Medicine Inc., Genentech, Roche, F. Hoffman-La Roche, GlaxoSmithKline, Heron Therapeutics, Harborside Press, American Society of Medical Oncology, Ipsen, NCCN, Kidney Cancer Journal, L-path, Merck, Michael J. Hennessy Associates, Research to Practice, Navinata Healthcare, NEJM, Novartis, Peloton, Pfizer, EMD Serono, Platform Q, Prometheus Labs, Sanofi/Aventis, Takeda, Tracon, Pionyr, Tempest, The Lancet Oncology, and Up-to-Date.Funding for this research was provided by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, N.J.
PORT AU PRINCE, Haiti, CMC – The United Nations peacekeeping mission in Haiti Monday called on all candidates in the second round of presidential and legislative elections on Sunday to show patience and restraint as they wait for the results of the vote.In a statement, the UN peacekeeping mission said that the message of restraint and clam was also being sent to the followers of the candidates, warning that the future of the impoverished Caribbean Community (CARICOM) country is at stake.“The second round of the presidential and legislative elections has concluded in considerably better conditions than the first round despite some logistical and administrative problems and isolated acts of violence in certain departments,” the UN Stabilization Mission in Haiti (MINUSTAH).“MINUSTAH congratulates the Haitian people for the patriotic spirit, calm and discipline which they have shown,” it added, praising the efforts of the authorities to make the run-off credible and allow the popular will to be expressed. “The evident enthusiasm of the electorate is clear evidence of the importance Haitians attach to democracy.”Former first lady Mirlande Manigat and popular musician Michel Martelly faced off in the presidential poll, which was delayed by two months when violence erupted after disputed first round results in December.Those results initially put Mrs. Manigat and outgoing President Rene Préval’s party candidate, Jude Celestin, in first and second place, qualifying for the run-off, with Martelly less than one percentage point behind in third place, but thus excluded.His supporters set up burning barricades of timber, boulders and flaming tyres. After a re-examination of the ballots, the Provisional Electoral Council (CEP) last month announced that the second run off would be between Martelly and Mrs. Manigat.Results of the second round are not expected for several days.“While awaiting the end of the counting and the tabulation of ballots, MINUSTAH urges all candidates and their followers to show patience and restraint, thus giving an example of democracy, since it is the future of the country that is at stake,” MINUSTAH said.MINUSTAH, with almost 12,250 uniformed personnel currently on the ground, has been in the poorest country in the Western Hemisphere since mid-2004 after then president Jean-Bertrand Aristide went into exile amid violent unrest.Aristide returned to the country mere days before Sunday’s poll despite pleas by the United States thayt his presence could affect the voting.Aristide’s Lavalas party was not allowed by the CEP to contest the elections.Source: Cana News Tweet Sharing is caring! Share Share 18 Views no discussions NewsRegional BE CALM: Haitians told to be patient and await presidential election results by: – March 22, 2011 Share
Area Girls Tennis Sectional ScoresWednesday (5-15)ConnersvilleRushville 3 Union County 2Franklin County 5 Connersville 0GreensburgGreensburg 3 Southwestern 2South DearbornEast Central 5 South Dearborn 0Batesville 5 Milan 0The Batesville High School tennis team posted a 5-0 win over Milan in the first round of the IHSAA sectional at South Dearborn.The Lady Bulldogs were led by senior Sophie Brown with a 6-0 and 6-2 win over Maitri Patel at No. 1 singles. Kate Poltrack and Jenna Ertel were also winners at No. 2 and 3 singles, respectively. Poltrack defeated Margo Taylor 6-0 and 6-3, while Ertel beat Lucy Ortt 6-1 and 6-0.The No. 1 doubles team of Corinne Stone and Betsy Harmeyer were 6-0 and 6-1 winners over Delaney Bushhorn and Cheyenne McMullen. Maggie Walsman and Lily Esser teamed up for a 6-2 and 6-3 win over Cici Bailey and Maddy Schmidt at No. 2.Courtesy of Batesville AD Bryan Helvie.
The Vikings qualified more wrestlers than any school in the San Gabriel Valley and had five Eastern Division champions last Saturday at La Quinta High. Inclan, a two-time CIF champion, started the season at 160 pounds, but dropped to 152 to make Northview a more lethal squad. He’s 41-2. “I am peaking at the very best time of the year and working really hard with my teammates,” Inclan said. “I have the best people possible to go against every day at practice.” Steven Salinas (103), P.J. Martinez (112), Dennis Rodriguez (125) and Steven DeLaFuente (140) all won championships for the Vikings. Martinez won his second CIF crown Saturday and DeLaFuente and Inclan were named lower and upper weight MVPs, respectively. “Mentally all are kids are fresh,” Northview coach Bobby Bellamy said. “Physically, at this time of the year, the kids everywhere are dinged up, but they’re ready to go.” “This weekend all comes down to who wants it the most.” Nick Inclan leads a cast of 11 Northview High School wrestlers into the two-day CIF-Southern Section Masters Meet at Carter High in Rialto beginning today. The top eight wrestlers from each weight class qualify for the State Meet, March 2-3 at the Rabobank Arena . in Bakersfield Thomas Williams (112) and Jonathan Aguirre (145) are among the five South Hills wrestlers vying for a spot at the State Meet. Williams (42-1), ranked No. 1 in the state at 112, dropped a 4-2 decision to West Covina’s Chris Armendariz in the Coastal Division semifinals, but feels the loss will serve as motivation. “I am fine mentally and I will be ready to go,” Williams said. “I am going to learn from my mistakes and move forward.” Sal Castillo (140) and Josh Pearson (189) have realistic chances of qualifying for State. George Munoz won the Masters 152-pound class last year and is again going in as an underdog for West Covina. The Bulldogs senior finished fourth last Saturday at the CIF Coastal Division finals in Huntington Beach and is ready to redeem himself. “I am very hungry right now,” Munoz said. “I started training Sunday for this weekend and expect to do well.” Munoz has one of the toughest draws in the area and will need to be at his best to advance. The Bulldogs have the second most entrants from the area with eight wrestlers. Taylor Louie (103), Armendariz (112) A.J. Guardado (135) and Munoz are expected to advance. Diamond Bar’s Marcus Johnson (215) may have flown under everyone’s radar, but that’s about to change. Johnson is 42-0 and won his first CIF title at the Southern Division championship at Chino Hills. “I am expecting to win Masters and do well at State, but I am not taking anything for granted,” Johnson said. “I am working hard every day to try and limit any mistakes in my mechanics.” Johnson’s teammate, Garrett Jones, will compete in the 189-pound division. Sierra Vista’s Adrian Gonzales (41-1) lost Saturday in the finals of the 152-pound division, but with that behind him, he is set to battle in possibly the toughest weight class in the area. Along with Inclan and Munoz, Gonzales looks to take the top spot and says he’s learned from his lone defeat this season. “I put Saturday behind me and I like my chances. I am really focused for this weekend and think I’ve corrected anything that needed to fixed,” Gonzales said. Angel Garcia, San Dimas’ 119-pound junior standout, won his third CIF title in as many years last Saturday at La Quinta. Garcia (45-3) has won titles at 103, 112 and now 119 and has his eyes set on a Masters title and a run at State. “I am going in this to win it, but I’ve had my mind on State all year,” Garcia said. “I am a lot more experienced this time around and have been working on minimizing mistakes.” Garcia has yet to place at State, but expects that to change next weekend in Bakersfield. Taylor Louie (103) might be the least recognized standout for West Covina, but at 36-1, he is primed and ready for a run at State. The senior’s lone loss was by disqualification and his coaches believe he’s possibly the most underrated wrestler in the area. “I’ve had one goal all year and that’s to be a state champion,” Louie said. “To be a state champ, you have to beat everybody and I am hoping to do that at Masters.” Bishop Amat will send two CIF Coastal Division champions, Steven Espindola (112) and Andrew Ortega (119), along with teammates Andrew Mascarenas (145), Andrew Hernandez (189) and Julian Silva (215) to the meet. West Covina coach Donnie Stephens is cautiously optimistic about the number of Bulldogs that will qualify for State. “When you get to Masters, anything can happen,” Stephens said. “I know our guys are ready mentally and physically.” The Bulldogs are a senior-led team and experience won’t be an issue this weekend. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
From Lalit K JhaWashington, Apr 29 (PTI) A top US lawmaker has alleged that China was helping Pakistan with intercontinental ballistic missiles (ICBMs) and claimed that it was also engaged in bullying its neighbours in Asia.”They (China) are thieves. They steal our intellectual property. Cyber attacks, I believe theyre responsible for those, theyre bullying Asia, trying to make new sovereign territory in the South China Sea and then claim the area around it,” Congressman Ted Poe alleged during a Congressional hearing on Asia yesterday.”Theyre helping Pakistan with ICBMs, and then you get to human rights, theyre the worst offender I think in the world,” he alleged.”They persecute Christians and other religious minorities, and then they have this practice of putting people they dont like, like the Falun Gong, in prison and charging them with trumped-up political crimes and then harvesting their body organs and sell those on the marketplace,” he said.”Thats probably the worst type of crime in the world, in my opinion,” Poe said during a House Foreign Affairs Committee hearing on Challenges and Opportunities in Asia.Deputy Secretary of State Antony Blinken testified before the committee but did not respond to the allegation of Poe that China is helping Pakistan with intercontinental ballistic missile.Earlier this week Poe and Congressman Mike Rogers in a letter to US Secretary of State, John Kerry, Defense Secretary Ashton Carter and Director of National Intelligence James Clapper sought more information on report that China has enabled a Pakistani nuclear missile capability.advertisementRogers is Chairman of the Subcommittee on Strategic Forces and Ted Poe is Chairman of Subcommittee on Terrorism, Non-proliferation and Trade.In their letter Rogers and Poe referred to a recent research by well know Chinese military technology expert Richard Fisher who has noted the design similarities between the Shaheen III TEL (transporter erector launcher), the Sanjiang Special Vehicle Corporation of the China Aerospace Science and Industry Corporation (CASIC) WS51200 TEL, and a Chinese provided TEL North Koreas new KN-08 intercontinental ballistic missile (ICBM).This led Fisher to conclude, “CASIC has again enabled a Pakistani nuclear missile capability,” the two lawmakers wrote in their letter to Kerry, Carter and Clapper.”We are deeply concerned that the TEL displayed in Pakistan was acquired from China,” Rogers and Poe said in the two-page letter. (MORE) PTI LKJ DBS CPS