Tom FennarioAPTN NewsIskweu (pronounced “is-kway”) is Cree for “woman.”It’s also the name for an initiative in Montreal that aims to prevent Indigenous homelessness.Tom Fennario has the firstname.lastname@example.org
WINNIPEG — Prices were higher in mid-morning trading at ICE Futures Canada on Thursday:Canola: Nov. ’17 $1.80 higher $495.20; Jan. ’18 $1.50 higher $501.20; March ’18 $0.50 higher $505.70; May ’18 $0.40 higher $508.20; July ’18 $0.30 higher $509.10; Nov. ’18 unchanged $485.80; Jan. ’19 unchanged $487.50; March ’19 unchanged $490.20; May ’19 unchanged $490.20; July ’19 unchanged $490.20; Nov. ’19 unchanged $490.20.Barley (Western): Oct. ’17 unchanged $145.00; Dec. ’17 unchanged $148.00; March ’18 unchanged $151.00; May ’18 unchanged $151.00; July ’18 unchanged $151.00; Oct. ’18 unchanged $151.00; Dec. ’18 unchanged $151.00; March ’19 unchanged $151.00; May ’19 unchanged $151.00; July ’19 unchanged $151.00; Oct. ’19 unchanged $151.00.
Inventor of World Wide Web wins computing’s ‘Nobel Prize’ SAN FRANCISCO – Most people who search on Google, share on Facebook and shop on Amazon have never heard of Sir Tim Berners-Lee. But they might not be doing any of those things had he not invented the World Wide Web.Berners-Lee, 61, is this year’s recipient of the A.M. Turing Award, computing’s version of the Nobel Prize.The award, announced Tuesday by the Association for Computing Machinery, marks another pinnacle for the British native, who has already been knighted by Queen Elizabeth II and named as one of the 100 most important people of the 20th Century by Time magazine.“It’s a crowning achievement,” Berners-Lee said in an interview with The Associated Press. “But I think the award is for the Web as a project, and the massive international collaborative spirit of all that have joined me to help.”The honour comes with a $1 million prize funded by Google, one of many companies that made a fortune as a result of Berners-Lee’s efforts to make the internet more accessible. He managed that largely by figuring out a simple way to post documents, pictures and video — everything, really, beyond plain text — online.SPINNING THE WEBStarting in 1989, Berners-Lee began working on ways digital object could be identified and retrieved through browser software capable of rendering graphics and other images. In August 1991, he launched the world’s first website, http://info.cern.ch .Besides coming up with the web’s technical specifications, Berners-Lee “offered a coherent vision of how each of these elements would work together as part of an integrated whole,” said Vicki Hanson, president of the Association for Computing Machinery.In an even more significant move, Berners-Lee decided against patenting his technology and instead offered it as royalty-free software. That allowed other programmers to build upon the foundation he’d laid, spawning more than a billion websites today that have helped lure more than 3 billion people online.CAUGHT IN THE WEBThe web’s widespread appeal gratifies Berners-Lee, who now splits his time shuttling between the U.S. and Britain as a professor at the Massachusetts Institute of Technology and the University of Oxford.But he fears parts of the web will become less accessible in the U.S. if the Federal Communication Commission dismantles regulations protecting “net neutrality.” That’s the principle that internet service providers should treat all websites equally instead of favouring some destinations that might be willing to pay for special treatment.If the Trump administration tries to dump net neutrality, “it’s going to have a fight on its hands because I think the American people realize it’s important,” Berners-Lee said. “It allowed America to benefit from a thriving internet market for connectivity and content. It has become part of the spirit of America.”Berners-Lee also worries about governments around the world using the internet as a surveillance tool, calling it a “recurrent threat.” He admits that preserving personal privacy as technology advances remains a thorny problem, one that he doesn’t have a ready solution for. But figuring that out is “really important to the future of society,” he says.“As an individual, I should be able to keep my own notes, keep my own journal and not share it with anybody. That is just part of being a person.”BEYOND THE WEBLike several other prominent figures in technology, Berners-Lee isn’t sure if humanity will be better or worse off as computers grow better at thinking like people via artificial intelligence.“Computing has grown exponentially more powerful, so It’s only logical that it will get to the point when computers will become smarter than us,” Berners-Lee said. “So, yes, we should logically think about those consequences.”This is the 50th anniversary of the A.M. Turing award, named after English computer scientist Alan Turing, whose revolutionary work with early computers and artificial intelligence helped crack Nazi Germany’s codes during World War II. Previous award winners include Vint Cerf and Robert Kahn, who did some of the pioneering work on the internet that Berners-Lee spun into the World Wide Web. by Michael Liedtke, The Associated Press Posted Apr 4, 2017 5:31 am MDT Last Updated Apr 4, 2017 at 7:00 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email
CLEVELAND — Rookie Collin Sexton scored a season-high 29 points and the Cleveland Cavaliers overcame 40 points by Houston’s James Harden to win consecutive games for the first time this season, beating the Rockets 117-108 on Saturday night.Sexton, taken with the eighth pick in the draft, was 14 for 21 from the floor and hit several key baskets in the second half as the Cavaliers held off multiple runs from the Rockets.Cleveland (4-14) won 121-112 in Philadelphia on Friday and rode that momentum against the Rockets, who played without star point guard Chris Paul.Harden, playing the entire second half, was 14 for 30 from the floor with 13 assists. The reigning MVP scored 24 points in the first half, including 15 for the second straight night in the first quarter. Harden has scored at least 30 points in four consecutive games.Harden made two free throws in the third quarter, but both were waved off because of his own foul line violations.Paul, who is second on the team in scoring and leads Houston in assists, was rested after the Rockets lost in overtime to Detroit on Friday. Eric Gordon started at point guard and scored 28 points.Tristan Thompson had 16 points and 20 rebounds for Cleveland. Jordan Clarkson added 20 points.Sexton and Clarkson hit baskets after Houston cut a 10-point deficit to 106-102 with five minutes to play. Rodney Hood’s 3-pointer gave Cleveland a 115-104 lead with 2:47 remaining.The first half had 12 lead changes. Cleveland hit five 3-pointers in the second quarter, including two by Kyle Korver that helped the Cavaliers go ahead 59-50. That was the biggest lead for either team in the half.MAPPING IT OUTThe Rockets want to be cautious with how much the 33-year-old Paul plays. The nine-time All-Star is in his 14th season.“The plan was always to monitor his workload,” coach Mike D’Antoni said.Paul scored 20 points in 37 minutes Friday. He averages 17.9 points and 7.7 assists in 15 games.EARLY STATSThe first quarter produced some unusually high numbers. The Rockets had six turnovers in the first four minutes, but didn’t turn the ball over again in the period. The Cavaliers were whistled for nine team fouls and were in the penalty midway through the quarter.TIP-INSRockets: Houston had won 10 of the last 12 meetings with Cleveland going into the game. … Friday’s game began a stretch that will see the Rockets play seven of nine on the road.Cavaliers: F David Nwaba started for the third straight game in place of Larry Nance. Nwaba had steals on Houston’s first two possessions that resulted in Cleveland baskets. … G George Hill (sprained right shoulder) has begun shooting drills, but coach Larry Drew isn’t sure when he’ll return. Hill has missed the last eight games.UP NEXTRockets: Visit Washington on Monday.Cavaliers: Host Minnesota on Monday.Steve Herrick, The Associated Press
Ms James suggested: “Meghan did so many self-checking gestures of anxiety which is interesting in such a confident woman.”She walked up the aisle on her own without batting an eyelid.”The duchess’s outfit – a beige Givenchy dress with caped shoulders – may have not been the ideal choice, Ms James said.”I think her outfit did her no favours. The caped shoulders restricted her arms and she lost some of her more natural movements.”But the Duchess soon eased into the day, and was a natural with the crowds who had gathered to catch a glimpse of her and her grandmother-in-law. “We saw displays which showed the pair genuinely having fun.”The Duchess of Sussex had her guard up in the morning, showing signs of anxiousness – not least when there as confusion over who was meant to get in the royal Bentley first. “Meghan was still being very careful. She sat with her legs crossed at the ankles and was clearly seeking approval,” said Ms James. The newlywed Duchess, who married the Duke of Sussex in a star-studded ceremony in Windsor last month, was nervous, repeatedly touching her hair. Their first engagement was a ceremony marking the opening of the new £1.86 billion Mersey Gateway bridge. The rapport between the pair was obvious, with the Duchess leaning in and talking to the Queen, producing what appeared to be fits of laughter from the 92-year-old. The Queen is greeted at Runcorn station with the Duchess standing behind herCredit:Peter Byrne/PA Ms James said the Queen was similarly beaming with smiles when she carried out her first joint engagement with the Duchess of Cambridge.They wrapped up their tour with lunch as guests of Cheshire West and Chester Council. The Duchess of Sussex leans in to seemingly share a joke with the QueenCredit:Danny Lawson/PA Next on their itinerary was Storyhouse, a cultural hub in the centre of town. The Queen and Duchess led crowds in a minute’s silence to mark the first anniversary of the Grenfell Tower disaster, solemnly bowing their heads.They then watched more performances, learned about “digital buddies” who were teaching their elders to use technology more efficiently, and took to the streets to meet thousands of well-wishers. Ms James described the monarch as having young body language for a woman of 92.”She looked positively girlish. When she smiles you can see the young princess coming out. She’s got a beautiful childlike smile and her little hands were formed into fists at one point. Perhaps Meghan did bring a little bit more of that out in her. It saw the pair deep in conversation, laughing and gesturing as they watched a seven-minute-long dance performance by children and enjoyed one another’s company. Ms James said: “The Queen doesn’t indulge in worries and she didn’t spend a lot of time checking on Meghan, but instead let her get on with it.”But when she did glance at her, it was with a beaming smile and approval.”She added: “The Queen was the happiest I’ve seen her in a long time. They looked like naughty teenagers giggling together at one point.” Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. The Queen laughs alongside the Duchess of SussexCredit:Jeff J Mitchell/Getty The Duchess of Sussex showed her nerves on her first joint engagement with the Queen, but there was genuine warmth between the monarch and Meghan, a body language expert said.Judi James said the head of state and the former Suits star giggled together like teenagers at one point as they enjoyed their day out in Cheshire.The Queen and Duchess travelled to Cheshire on the Royal train, leaving Euston at 11pm on Wednesday and spending the night in a discreet siding en route before pulling into Runcorn station at 10.35am for the Duchess’ first trip to the north of England. Greeted by the Lord Lieutenant of Cheshire, the Duchess lingered behind the Queen, appearing slightly nervous as she watched for instructions about where to go. After a moment of confusion at their waiting car, as both politely waited for the other to get in, the Duchess asked her grandmother-in-law “what is your preference?” before being told: “You go first.” The Queen wore a green outfit by Stewart Parvin, choosing a colour some onlookers interpreted as a gesture of support on the anniversary of the Grenfell Tower disaster.
Dacian Gold has declared commercial production at its Mt Morgans gold operation in Western Australia, some nine months after producing its first gold bar at the mine.The declaration, made on January 1, followed combined mining rates across the operation achieving feasibility study-design levels during the December quarter, the company said.Production for the December quarter totalled 37,930 oz, a significant increase on the prior quarter and in line with the company’s guidance of progressively increasing output throughout its 2019 financial year. Gold poured for that quarter totalled 38,479 oz.Dacian said underground mining was now underway across all three declines at Westralia (Beresford South, Beresford North and Allanson), while, at the Jupiter open pit, higher‐grade ore in the Cornwall Shear Zone was expected to be mined later in the current March quarter.This combined progress across the operation will support continued operational momentum and underpin further quarterly increases in production throughout the remainder of Dacian’s 2019 financial year, the company said.Dacian Gold Executive Chairman and CEO Rohan Williams said the declaration of commercial production was another example of the company meeting its development and production targets.“We are pleased to have achieved this important milestone – exactly when we said we would,” he said. “It was an outstanding quarter, with production increasing 30% from the September quarter.”Mt Morgans is expected to produce around 200,000 oz/y of gold at an all-in sustaining cost of around A$1,000/oz ($716/oz) when fully ramped up. This will come from a reserve base that totals 1.4 Moz.
Rovio is attempting to, and has succeeded for the most part in getting Angry Birds on to every available platform. They’ve even had some help catering to outdated platforms with the game appearing on the Sega Genesis.Lots of platforms means a number of input methods, and Angry Birds on PC/Mac just got new one in the form of a custom force-feedback USB controller.We’ve already seen a USB slingshot created for the game, but this project is a little more advanced. It’s called the Super Angry Birds (SAB) controller, and gives you complete control over the angle and force used to fire the bird out of the slingshot. It even includes a detonator for use with those special birds.To SAB controller was created in a Haptics class at the Copenhagen Institute of Interaction Design by Hideaki Matsui and Andrew Spitz. It brought together a range of technology including a motorized fader more commonly found in an audio mixing console, an electric motor, and an Arduino board.The fader is what slides back and forth to simulate the slingshot on-screen. The electric motor is used to apply an opposing force to catapult the bird and provide the force-feedback. Matsui and Spitz then created a force curve so they could track the force applied and transmit the appropriate input to the game. All programming was done using the visual programming tool MAX.It certainly adds something to the game that you won’t get from the more typical key or touchscreen input. If they could package this controller up into a more compact, cleaner unit, I bet they’d get backing on Kickstarter to ship it.Read more at sound + design
File photo Image: bedimage via Shutterstock 7,751 Views File photo Source: Simon Harris TD/Twitter Image: bedimage via Shutterstock Updated 7.55amTHIS MONTH STARTED off with 601 patients on trolleys and in wards, waiting on a bed, according to the latest figures from the Irish Nurses and Midwives Organisation.While the trolley figures relate directly to accident and emergency departments, the ward figures count the number of additional patients on trolleys and chairs in excess of the listed capacity of these wards, which intends to give a general overall picture of overcrowding in hospitals.The Irish Association of Emergency Medicine described the latest figures on trolleys as “Groundhog Day”.Many of the major Dublin hospitals had in excess of 20 patients on trolleys, with Beaumont (38 patients) and Tallaght Hospital (41) having the highest number in the capital.Further afield, the highest numbers across the country could be found in University Hospital Limerick (48), Cork University Hospital (43) and University Hospital Waterford (38).The overall number of patients on trolleys had been declining over the course of this month, after reaching a peak at the beginning of January.In the trolley watch figures for Monday 30 January, there were only 445 people on hospital trolleys, with increase in numbers in Dublin hospitals such as Connolly Hospital and St James’s Hospital helping to raise the trolley watch figures above 600 to kick off February.The high number of hospital admissions at the beginning of January led to national ambulance service members reporting delays of between one and three hours admitting patients to A&E.The crisis in emergency departments saw Health Minister Simon Harris describing the situation as a “perfect storm”. The latest figure of 601 patients on beds is only just short of the record high 612 observed on 3 January.Responding to the current trolley situation, the Irish Association of Emergency Medicine said in a statement: “Yearly ‘plans’ and ‘Winter Initiatives / Plans’ have failed to address the issue and the HSE continues to condemn further patients to this very unsafe situation day in, day out.How long do we have to remain stuck in this loop where there is a clear solution to the problem (the creation of additional bed capacity) and this solution is deliberately ignored?If no improvement is made in the next year, they fear that another 300 to 350 patients will have died needlessly by this date next year.Speaking on RTÉ’s Morning Ireland, Consultant in Emergency Medicine Fergal Hickey said that they were “very sure” that up to 350 patients would die, who otherwise would not have died, by this time next year if overcrowding continued.This opinion is based on studies from Australia, which they have applied to the Irish situation.“The evidence is very clear on this,” Hickey said. He added that at least one or two die unnecessarily in his own hospital in Sligo due to this problem each year.“I’ve had to apologise to families where their experience has resulted in a bad outcome,” he said.The key issue is the shortage of beds. There was a shortage of beds before austerity, and this shortage was worsened by austerity.He pointed to a decrease in beds in the face of increasing demand as exacerbating the problem.Hickey added that restoration of around 1800 beds he said were taken away during austerity, and the provision of several hundred more would be an essential first step in relieving the burden of high numbers on trolleys.Simon Harris responded at the time of the programme airing by tweeting the measures he believes will alleviate the problem. ‘Groundhog Day’ as month begins with 600 people on hospital trolleys The figure of 601 is just short of the high of 612 patients on trolleys at the beginning of January. Share126 Tweet Email Thursday 2 Feb 2017, 7:29 AM Short URL 3 key measures underway to break vicious overcrowding cycle -1) bed capacity review, 2) recruitment & 3) new gp contract @CathalMacCoille— Simon Harris TD (@SimonHarrisTD) February 2, 2017 29 Comments Read: ‘If this many people were dying in another way, there’d be war over it’Read: How Ireland’s hospitals are massaging the numbers of people on trolleys http://jrnl.ie/3218160 Feb 2nd 2017, 7:29 AM By Sean Murray Tweet thisShare on FacebookEmail this article
A new initiative is set to make Greece’s beaches – arguably the country’s most famous asset – more accessible for people with mobility problems. The initiative is part of the Tsipras government’s social policy program to promote equal rights to people with disability. According to the announcement, the government aims to build infrastructure and install all appropriate equipment to a significant number of beaches within 2018, so that they are ready by the beginning of the next tourist season to welcome anyone who is excluded from beaches at the moment – notably the disabled, the elderly, pregnant women and people recovering from injuries and illness. The program is aiming to improve the quality of life of people living with disability in Greece, but also to attract more tourists to the country, making it a preferred destination for people with disability. The project is an initiative emanating from Prime Minister Alexis Tsipras’ social policy office, which mobilised the economy and development ministry to draw up a plan to install infrastructure, giving independent wheelchair access to the sea and related facilities. The infrastructure will consist of non-permanent assembled mechanisms, as well as specially designed changing cabins, portable toilets, ramps, parking areas and areas providing shade and protection.The policy was announced by the Ministry of Economy and Development, which is responsible for implementing the plan, in accordance with the UN Convention of the Rights of Persons with Disabilities (which was recently made a law of the state), but also with the EU ‘Europe 2020’ strategy for growth and employment, which emphasises sustainable and inclusive policies. On Monday, the ministry will invite offers, with a budget set at €5 million in total, with a maximum of €60,000 per facility. Among potential beneficiaries are municipalities on the coast, which can each bid for up to four, and the Public Properties Company. Facebook Twitter: @NeosKosmos Instagram
La plus ancienne stratégie de défense animale : se recroquevillerPubliant ses travaux dans la revue Biology Letters, une équipe internationale a mis en évidence, chez des trilobites – des arthropodes fossiles – d’environ 500 millions d’années découverts au Canada, un comportement de défense consistant à se lover à l’intérieur de leur squelette externe. Les trilobites, ces arthropodes marins du Mésozoïque disparus il y 250 millions d’années et qui sont des cousins éloignés des araignées et des crustacés, détiennent un record : celui d’être les plus anciens animaux à montrer aux paléontologues leurs stratagèmes de défense. C’est ce qu’ont confirmé des chercheurs de l’Université de Cambridge (Royaume-Uni) et de l’Académie des sciences à Nankin (Chine) en découvrant des fossiles de ces animaux pliés sur eux-mêmes, dans une formation géologique des Rocheuses canadiennes, dans l’Alberta.Antérieurement, de nombreux trilobites fossilisés – très appréciés des collectionneurs pour leurs superbes ‘coquilles’ (exosquelettes) aux formes diverses et variées – avaient déjà été trouvés avec les pattes et les antennes recroquevillées autour du corps roulé en boule, à l’intérieur de leur squelette externe : une stratégie de défense un peu similaire à celle du cloporte d’aujourd’hui. Mais ces spécimens, jusqu’à présent, étaient bien plus récents que ceux découverts cette fois-ci.La plupart, en effet, étaient postérieurs à la période cambrienne, qui s’est terminée il y a environ 485 millions d’années (Ma). Or, l’équipe sino-britannique a trouvé des trilobites en position de défense qui remontent au Cambrien inférieur (il y a 542 à 513 Ma). Ces premiers ‘contorsionnistes’, toutefois, n’avaient pas entièrement maîtrisé la technique : contrairement aux trilobites plus récents, ils ne pouvaient que se plier en deux et devaient maintenir cette position au prix d’un effort musculaire constant.Des spécimens morts englués À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Cette dernière caractéristique explique que les paléontologues, jusqu’à présent, n’avaient encore pu mettre la main sur des trilobites à la fois aussi anciens et toujours en position de repli sur soi : la mort entraînant un relâchement des muscles, l’animal doit généralement reprendre sa posture étendue avant que le phénomène de fossilisation ne se mette en œuvre. Les nouveaux spécimens, eux, ont probablement été ensevelis vivants, figés dans leur position enroulée par un matériau minéral engluant tout le corps.(crédits photo : Javier Ortega-Hernández, University of Cambridge) Le 29 septembre 2013 à 19:15 • Maxime Lambert
Tags Google will continue to work with Huawei for now. Getty Google said Tuesday it will continue working with Huawei for 90 days, after the US government announced it’s temporarily scaling back trade restrictions on the Chinese smartphone maker.On Monday, the US Commerce Department said it’s creating a general license that for now lets Huawei keep existing networks and issue updates to its phones and tablets. The reprieve is meant to give US companies time to figure out longer-term solutions and to protect consumers from security risks. The license expires on August 19. “Keeping phones up to date and secure is in everyone’s best interests and this temporary license allows us to continue to provide software updates and security patches to existing models for the next 90 days,” a Google spokesperson said in a statement. Huawei didn’t immediately respond to a request for comment. Now playing: Watch this: Comments Huawei P30 Pro vs. Galaxy S10 Plus: Editors react Phones Share your voice 6:54 Google’s decision not to cut ties with Huawei, the second largest smartphone company in the world, is a reversal of plans it announced earlier this week after the Trump administration effectively banned Huawei from the US, restricting the company’s access to US components and software. For Google, that meant suspending some business with Huawei, a key partner for its Android mobile operating system. Google reportedly said that it would stop providing Huawei with customer support and that upcoming versions of Huawei’s phones outside China would no longer get access to Google’s Play Store app marketplace and its marquee slate of services, including YouTube and Google Maps. Huawei, though, would still have access to the open-source version of Android without Google services. It’s unclear what Google will do after the 90-day license expires. Read: Samsung has the most to gain from Google putting Huawei on ice 4 Google Huawei Alphabet Inc.
Bangladesh Awami League general secretary Obaidul Quader. File PhotoDescribing BNP’s election manifesto as a colourful balloon full of unrealistic pledges, Awami League general secretary Obaidul Quader on Tuesday said it will implode immediately if the party comes to power, reports UNB.”BNP has presented some unrealistic and weird promises which can’t be fulfilled,” he said, describing the election manifesto as the best joke of the year.The AL leader came up with the remarks while talking to reporters at a restaurant by the Dhaka-Chattogram highway in Chouddagram upazila of the district.BNP rolled out its manifesto for the 11th parliamentary elections on Tuesday with a set of promises, including making democracy an everyday practice, building a vengeance -free Bangladesh and raising GDP growth to 11 percent.
Explore further Potential therapeutic target for Parkinson’s disease (Phys.org)—A team of researchers at Stanford University has used ultrafast x-ray absorption and emission spectroscopy to quantify the entatic state of cytochrome c. In their paper published in the journal Science, the group outlines their procedure and what they learned. Kara Bren and Emma Raven with the University of Rochester and University of Leicester respectively offer a Perspective piece on the work done by the team in the same journal issue, and outline some of the implications regarding the role that the protein plays in cell life and death. More information: Metalloprotein entatic control of ligand-metal bonds quantified by ultrafast x-ray spectroscopy, Science (2017). science.sciencemag.org/cgi/doi … 1126/science.aam6203AbstractThe multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and apoptosis, switching function by modulating bonding between a heme iron and the sulfur in a methionine residue. This Fe–S(Met) bond is too weak to persist in the absence of protein constraints. We ruptured the bond in ferrous cyt c using an optical laser pulse and monitored the bond reformation within the protein active site using ultrafast x-ray pulses from an x-ray free-electron laser, determining that the Fe–S(Met) bond enthalpy is ~4 kcal/mol stronger than in the absence of protein constraints. The 4 kcal/mol is comparable with calculations of stabilization effects in other systems, demonstrating how biological systems use an entatic state for modest yet accessible energetics to modulate chemical function. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org Citation: Energetic cost of the entatic state of cytochrome c quantified (2017, June 23) retrieved 18 August 2019 from https://phys.org/news/2017-06-energetic-entatic-state-cytochrome-quantified.html A change in the active-site conformation turns cytochrome c from an electron shuttle in respiration to a peroxidase enzyme for apoptosis. Credit: (c) Science 23 Jun 2017: Vol. 356, Issue 6344, pp. 1236 , DOI: 10.1126/science.aan5587 Journal information: Science Cytochrome c is a protein that exists in many plants, animals and unicellular organisms. In humans, its main purposes are ferrying electrons in mitochondria and assisting with apoptosis (normal cell death and the processes surrounding it.) These two functions have been shown in prior efforts to rely on the position of methionine residue. When sulfur works with iron, the protein is ready to transfer electrons. Otherwise, it engages in peroxidase activities. In this new effort, the researchers sought to better understand the energetics of the protein by probing the iron and sulfur bond. Entatic states, Bren and Raven point out, are very important in bioinorganic chemistry—it actually translates to something that is stretched when subjected to tension.To better understand the bond between the two elements, the researchers temporarily forced them apart using a Linac Coherent Light Source X-ray free electron laser and then timed how long it took the two components to reform using iron X-ray emission spectroscopy. They found that the environment in which they existed boosted bond strength by four kilocalories per mole, which was enough to allow the protein to toggle between its functional states and to quantify the energy cost of the entatic state.As Bren and Raven note, the results of the study have implications regarding the role that cytochrome plays in respiration, which they relate to living and apoptosis, which they relate to death. To promote continued living the protein helps to maintain a certain reduction potential. For apoptosis, the entatic state is disrupted allowing peroxidase activity to be enhanced.
A 13-year-old Indian-origin boy in London died last month after suffering a severe allergic reaction to a piece of cheese. According to media reports, Karanbir Cheema was allergic to wheat, gluten and dairy and his condition was well known at school but he came in contact with the allergen in cheese as it was allegedly forced on him by a schoolmate.Food allergy or intolerance, which can cause symptoms ranging from a harmless skin rash to a potentially lethal anaphylactic shock, are estimated to affect four to six per cent of children and four per cent of adults, according to the US Centers for Disease Control and Prevention (CDC).If left untreated, a food allergy can turn fatal, especially in children, because the body’s immune system considers the proteins and complex carbohydrates present in the food as foreign.”It is only in rare cases that one can get a severe allergic response to any food allergen. Food items like cheese have other ingredients which may have caused severe allergic reaction. Commonly mild allergy, however, does not cause such severe reactions,” said Vivek Raj, Director (Gastroenterology), Max Super Speciality Hospital.According to the US Food and Drug Administration (FDA), there are eight foods that are common for allergic reactions in a large segment of the sensitive population. These include, peanuts, tree nuts, eggs, milk, shellfish, fish, wheat and their derivatives, soy and their derivatives, and sulphites (chemical-based, often found in flavours and colours in foods) at 10 parts per million (ppm) and over.These can cause several types of allergies such as skin manifestations which include rashes, swelling and itching, respiratory symptoms including wheezing, bronchospasm and choking and gastrointestinal symptoms including cramping, vomiting and diarrhoea. Some also cause low blood pressure which manifests as light-headedness, dizziness or even a fainting spell.Allergy to any food item may cause bronchial secretions, which can lead to bronchospasm – a sudden constriction of the muscles in the walls of the bronchioles in the respiratory tract.”As a result, the patient experiences choking and breathing difficulty, which, if not treated timely, may increase the risk of death,” added Rakesh Gupta, Senior Consultant, Apollo Hospitals.Further, children are much more vulnerable to food allergies than adults as the allergies fade away by adulthood.”As children grow older, they outgrow some of the allergies as their immune system matures. Also, the allergens are identified in childhood and then the person learns to avoid those as an adult,” Raj noted. However, allergies are not just hereditary but may be related to gender, according to recent research published in the Journal of Allergy and Clinical Immunology.The study revealed that the genetic risk of a child having allergies doubles if the parent of the same sex is an allergy sufferer. Thus, mothers pass the risk of allergies to their daughters, as do fathers to their sons.Moreover, food allergies can worsen other conditions such as asthma and diabetes. If a patient already has other allergy-linked conditions like asthma, then the impact of food allergy can be more, doctors said. “As there is no cure to food allergy, the only way to prevent it is not to eat that food item,” suggested Ritika Samaddar, a Delhi-based nutritionist.”The allergy can be confirmed by skinprick tests and/or bloods tests to measure the allergy antibodies,” she added. Because fatal and near-fatal food allergy reactions can occur at school or other places outside the home, parents of a child with food allergies need to make sure that their child’s school has a written emergency action plan. The plan should provide instructions on preventing, recognising and managing food allergies and should be available in the school and during activities such as sporting events and field trips, experts suggested. However, “if any allergic item is consumed, the patient should be immediately rushed to the hospital. No drug should be taken without a doctor’s prescription”, Gupta said.
The Minister of State (Independent Charge) for Micro, Small and Medium Enterprises Giriraj Singh, on Monday, said that following the ‘Khadi for Fashion’ call by Prime Minister Narendra Modi, the ministry had planned to connect at least five crore village women to Charkha (spinning wheel).Addressing the Gandhi Jayanti Celebrations at Khadi Bhawan in Connaught Place, the minister said that Khadi has now become popular among younger generation too. “For a significant span of time Khadi was meant for either dadaji (older ones) or netaji (politicians). But, due to the initiatives and appeals made by our Prime Minister – who is himself the latest USP of Khadi –Khadi has now become a fashion trend among the youth,” he said, adding, “Even the results speak. The previous governments could increase the sale by only 70 percent in 10 odd years, but we enhanced it to 90 percent.” Also Read – Add new books to your shelfSpeaking of solar charkhas, the minister said that it would provide employment to at least five crore village women in the coming five years. “With five pilot projects at Varanasi, Nawada and other places, we are already on our heels with this project. It will ensure a regular income between Rs 6000 and Rs 10,000 to each of the women,” he said. The minister claimed that in efforts to make Khadi a fashion brand across the globe, the department is in regular contact with all leading fashion institutes of the country. Also Read – Over 2 hours screen time daily will make your kids impulsiveSingh further added that even in Africa, as a part of centenary Year celebrations of Gandhiji’s Swadeshi Movement, the High Commission of India in Uganda, in association with the Republic of Uganda, is unveiling the Gandhi Charkha – gifted by Khadi and Village Industries Commission (KVIC) – at the Gandhi Heritage Site at Jinja in Uganda. Khadi and Village Industries Commission (KVIC) Chairman Vinai Kumar Saxena, in his address, said that Khadi has been spreading its wings in all directions for creating maximum job opportunities for the artisans. “Since sanitation and Khadi was close to Mahatma Gandhi’s heart, the KVIC is all set to take his legacy forward,” he said, adding, “We have also taken Prime Minister’s call of ‘Sweet Revolution’ very seriously and we are trying to give a major push to our ‘Honey Mission’ in the coming days.” Arun Kumar Panda, secretary, MSME, also laid stress upon enhancing the total turnover of Khadi and Village Industries. Earlier, the minister inaugurated 60 Khadi outlets – which were renovated and re-launched during the completion of KVIC’s 60th anniversary and a Khadi outlet at Chaudhary Charan Singh International Airport at Lucknow, through remote device. He also handed over the cheques to five artisans each from two Khadi institutions of Uttar Pradesh and Haryana, under the new sales initiatives undertaken by KVIC. Later, he inaugurated a Honey Parlour – showcasing several qualities of honey – at Palika Bazaar.