Tag: 南京夜网

Man charged for narco possession

first_imgA man was on Friday taken before Magistrate Christel Lambert at the Vreed-en-Hoop Magistrate’s Court charged with possession of cannabis.Kevin Mohan, 18, of West Coast Demerara pleaded not guilty to the offense which alleged that on June 24, 2016, he had in his possession seven grams of cannabis.The Prosecution’s case is that on the day in question, Mohan was seen by Police acting in a suspicious manner. As such a search was carried out on his person and the drug discovered in his pants pocket. He was cautioned and taken to the Vreed-en-Hoop Police Station where he was arrested and charged.According to the information disclosed by the Police Prosecutor, the defendant said that he usually sells the drugs.In court on Friday, the defendant told the Magistrate that the drugs do not belong to him but that he is given it to sell.He was remanded to prison and will return to court on July 21.last_img read more

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HUGE NUMBER OF EVENTS TO TAKE PLACE DURING DONEGAL HERITAGE WEEK

first_imgNational Heritage Week takes place Saturday, August 22 to Sunday, August 30, 2015 with Donegal hosting a huge number of events.The aims of Heritage Week are to raise awareness of our heritage and to encourage its preservation, conservation and promotion.County Donegal is the county with the most events taking place outside of Dublin and Cork. Events include heritage open days, guided walks, fieldtrips, exhibitions, conferences, illustrated talks, historical re-enactments, birds of prey, whale watching, garden tours, traditional skills demonstrations, craft fairs, skills training, launch events, film screenings, storytelling, traditional music and children’s activities.The County Donegal Heritage Week Event Guide is compiled by the County Donegal Heritage Office, Donegal County Council and is a free, pocket-size guide with details of 105 Heritage Week events taking place across County Donegal and most of them are free. The County Donegal Heritage Week Event Guide will be launched by Dr. Lochlann McGill, President of the Donegal Historical Society, in the County Museum, Letterkenny next Tuesday, August 11 at 12 noon. Everyone is welcome to attend. RSVP to County Museum at HYPERLINK “mailto:museum@donegalcoco.ie” museum@donegalcoco.ie or by telephone on (074) 912 4613.HUGE NUMBER OF EVENTS TO TAKE PLACE DURING DONEGAL HERITAGE WEEK was last modified: August 5th, 2015 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Donegal Heritage Weeklast_img read more

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New wildlife sanctuary to open in Inishowen to protect rare species

first_imgPlans to open a new wildlife sanctuary in Inishowen took another step closer this week as the 22-acre site was given the go-ahead. It is hoped that the site, which is based in Dundrean in Burnfoot, could be opened within the next two months.The person behind the sanctuary, Buncrana solicitor Killian McLaughlin, is building with the aim of creating a worthy habitat for a range of different Irish animals including the rare red squirrel, foxes, hedgehogs, red deer and birds. The sanctuary, which could attract up to 24,000 visitors per year, will incorporate a reception building, vehicular entrance with car park, rehabilitation units, open viewing areas and a below the water viewing area.The site will also host a visitor centre and a score of enclosures for wildlife homed in the facility.It is understood that visitor numbers will be kept to a minimum once the sanctuary opens, with a view of using the facility to educate school children to the rich diversity of wildlife across Donegal.Cllr Nicholas Crossan, Cathaoirleach of the Donegal County Council, said he believed the development will be a great attraction for Inishowen. He told Donegal Daily: “The site is very near completion, with the launch possibly in the next six weeks, that is the hope because Killian (McLaughlin) is not ready to go yet, but he will be very shortly.“I think it will be a fabulous attraction and unique wildlife sanctuary for the area and for educational purposes, I think it will be a great idea for the Donegal area.“And especially now, when climate change is a big topic of discussion, it will be interesting to learn and watch how these beautiful animals, that people don’t realise are in their own backyards, live and survive in the wild,” Crossan added.“It will be fantastic to teach children more about nature and the spot itself is a cracking spot that has been kept as natural as possible.”New wildlife sanctuary to open in Inishowen to protect rare species was last modified: August 7th, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

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Heritage-led regeneration of Church Lane in Letterkenny continues

first_imgAs the Historic Towns Initiative on Church Lane, Letterkenny nears completion, a delegation from The Heritage Council and the Department of Culture, Heritage & the Gaeltacht visited project partners to view progress.Under the Historic Towns Initiative, conservation works are taking place to seven historic properties.The works include roof and chimney repairs, installation of cast-iron rainwater goods, reinstatement of timber sash windows and doors, application of lime render or lime pointing, and the repair of a historic shopfront using traditional materials and informed by best conservation practice. The conservation works are being funded by The Heritage Council, Donegal County Council and the private landowners.“The partnership between the Letterkenny Cathedral Quarter, Donegal County Council, Dedalus Architecture and private landowners established under the Historic Towns Initiative has worked very well” explained Joseph Gallagher, County Donegal Heritage Officer.“This collaborative way of working has provided us with mechanisms that facilitate heritage-led regeneration in our towns and villages and encourage greater community cohesion.“The project has also encouraged greater cross-directorate cooperation within Donegal County Council as the Conservation Office within the Community Development and Planning Directorate and the Heritage Office within the Housing, Corporate and Culture Directorate were joint project leaders. The successful approach adopted for Church Lane can be applied elsewhere.” “The Historic Towns Initiative builds on several community-led initiatives instigated by the Letterkenny Cathedral Quarter as well as the designation of the Ecclesiastical Architectural Conservation Area under the Letterkenny Local Area Plan” said Collette Beattie, Conservation Officer, Donegal County Council.“Initiatives such as the ‘Save the Church Lane’ campaign started in January 2014, the Heritage Streets Alive project in 2015, the Church Lane Conservation Plan in 2016 and the Collaborative Town Centre Health Check in 2018 established strong community support and strong evidence-based support for the heritage-led regeneration of Church Lane.“The Historic Towns Initiative has benefitted immensely from the voluntary and dynamic approach of the Letterkenny Cathedral Quarter Committee, the grade one conservation expertise of Dedalus Architecture and the shared vision of the property owners.”During their visit to Church Lane, officials from The Heritage Council and the Department of Culture, Heritage and the Gaeltacht enjoyed lunch with project partners in the Wholegreen Restaurant on Church Lane before going on a guided tour of the Historic Towns Initiative conservation works.Donnan Harvey and Shane Toolin of the Letterkenny Cathedral Quarter Committee highlighted the work of their group over the past five years and their aspirations for Church Lane. Conservation architect Duncan McLaren, Dedalus Architecture outlined the conservation works to the seven historic buildings and property owners spoke about their future plans to bring their properties back into use.The funding of €200,000 awarded by The Heritage Council and the Department of Culture, Heritage and the Gaeltacht for the Historic Towns Initiative on Church Lane, Letterkenny was the largest allocation of the six successful historic towns across Ireland under this year’s scheme.This funding is being supplemented with €40,000 from Donegal County Council and private funding from Church Lane property owners. It is anticipated that the conservation works as part of the Historic Towns Initiative on Church Lane will be completed later this month and The Heritage Council indicated that the work on Church Lane will be profiled at a national seminar on the Historic Towns Initiative in Kilkenny in January 2020.Heritage-led regeneration of Church Lane in Letterkenny continues was last modified: November 11th, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:Church LaneHeritage Councilletterkennyregenerationlast_img read more

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Embryonic Stem Cells Left in iPS Dust

first_img Have embryonic stem cells made any headway toward cures?  It’s sometimes hard to tell in news reports.  Science Daily ran a story from Monash University about research on how stem cells in the embryo differentiate into muscle tissue, for the purpose of helping the elderly who suffer from age-related muscle wasting conditions, but did not indicate whether human embryos were involved in the research.  It appears they studied chicken embryos to watch what happens as the stem cells develop into muscle, not for the purpose of injecting embryonic stem cells for treatment.     A paper in Nature about embryonic stem cell research appears limited to understanding transcription in normal animals,3 without any mention of potential applications for human health.  Similarly, an article on Science Daily discussed how scientists at the University of Pennsylvania are trying to understand how embryonic stem cells differentiate in living organisms.  While the press release stated that “Investigators want to make embryonic stem cells for liver or pancreatic beta cells for therapies and research,” there was no indication that the team has come anywhere close to that goal.  “By better understanding how a cell is normally programmed we will eventually be able to properly reprogram other cells,” one of them said.  Once again, embryonic stem cell therapy looks like a pipe dream.     Is there a “state of the stem cell” address?  An overview of stem cell research was provided by Erika Check Hayden in Nature,4 who said, “The field of induced pluripotent stem cells has grown up fast.  Now it is entering the difficult stage.”  She focused on the promise of iPS cells which are changing the face of biology.  “Like human embryonic stem cells, iPS cells could potentially be used as therapies, disease models or in drug screening,” she wrote.  “And iPS cells have clear advantages: they can be made from adult cells, avoiding the contentious need for a human embryo, and they can be derived from people with diseases to create models or even therapies based on a person’s genetic make-up.”     From there, Hayden described some of the “growing pains” of iPS stem cell research, but never mentioned any case in which embryonic stem cells are clearly superior to the ethics-friendly iPS cells.  The ease of reprogramming adult cells into pluripotent stem cells has led to a gold rush of research into promising therapies.  In spite of the fact that (as often happens in biology), “things are not as simple as we thought,” it was noteworthy that the thrust of Hayden’s article was about the strong momentum in the iPS research community.  The silent subtext is that embryonic research has apparently lost a lot of steam.  A few years ago, scientists were clamoring for access to human embryos for stem cell research.  Now, the discovery of induced pluripotent stem cells (iPS) from human skin and other adult tissues has sidetracked interest in embryonic stem cells.  The momentum is clearly going with iPS.  Is there any longer a need for embryonic stem cell research? 1.  Chen, Lu, Cheng, Peng, and Wang, “Isolation and Characterization of Porcine Amniotic Fluid-Derived Multipotent Stem Cells,” PLoS One 6(5): e19964. doi:10.1371/journal.pone.0019964. 2.  Panopoulos, Ruiz et al, “Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells,” PLoS One 6(5): e19743. doi:10.1371/journal.pone.0019743. 3.  Pastor, Pape, Huang et al, “Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells,” Nature, published online 08 May 2011, doi:10.1038/nature10102. 4.  Erika Check Hayden, Stem cells: The growing pains of pluripotency,” Nature published online 18 May 2011; Nature 473, 272-274 (2011); doi:10.1038/473272a. It has been very encouraging for people who value ethics to see adult stem cell research take off, leaving embryonic stem cell research in its rear-view mirror.  But what if it had turned out the other way?  What if embryonic stem cells were actively producing cures?  Experimenting on human embryos would still be unethical.  A basic principle of ethics is that ends do not justify the means (see commentary from the 09/03/2010 entry).  The past decade of stem-cell research has shown that some scientists’ greed for fame and money outruns their interest in ethics.  It takes a concerned public to keep science in check, because scientists are only human, prone to the same moral lapses as the rest of us.(Visited 19 times, 1 visits today)FacebookTwitterPinterestSave分享0center_img Skirting controversy:  “Stem cell research courts both controversy and support in the community- depending on your viewpoint,” began an article on Medical Xpress.  “Now, for the first time, scientists at Monash University’s Immunology and Stem Cell Laboratories (MISCL) have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.”  A side-by-side comparison showed the kidney cells were just as good as embryonic stem cells in producing various tissues. Chemotherapy-resistant bone marrow:  Another article on Medical Xpress reported work at the Fred Hutchinson Cancer Research Center that stem cells from bone marrow can be genetically modified to resist damage from chemotherapy, helping cancer patients endure the treatment without harmful effects.     Previously, chemotherapy treatments for gliablastoma, a brain cancer, have taken a harsh toll on patients’ bone marrow.  “Our initial results are encouraging because our first patient is still alive and without evidence of disease progression almost two years after diagnosis,” a doctor said. Parkinson’s disease:  Researchers from South Korea and Harvard have identified a “protein-based” human iPS cell” that appears promising for reversing nerve cell loss in patients with Parkinson’s Disease.  Their experiments “reversed disease when transplanted into the brain of rats modeling Parkinson disease.”  Though the article mentioned embryonic stem cells as one of the two sources of stem cells, it did not produce any evidence that embryonic stem cells are effective – only the iPS cells. Vision forum:  Eye diseases such as “age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and other retinal diseases” affect millions worldwide, an article on Medical Xpress said.  Can iPS stem cells from human skin treat these devastating conditions?  Apparently so; “Scientists from Schepens Eye Research Institute are the first to regenerate large areas of damaged retinas and improve visual function using iPS cells (induced pluripotent stem cells) derived from skin,” they said.  A paragraph in the article shows that many vision researchers would prefer to avoid ethical controversies with embryonic stem cells: While Tucker, Young and other scientists were beginning to tap the potential of embryonic and adult stem cells early in the decade, the discovery that skin cells could be transformed into “pluripotent” cells, nearly identical to embryonic cells, stirred excitement in the vision research community.  Since 2006 when researchers in Japan first used a set of four “transcription factors” to signal skin cells to become iPSCs, vision scientists have been exploring ways to use this new technology.  Like embryonic stem cells, iPSCs have the ability to become any other cell in the body, but are not fraught with the ethical, emotional and political issues associated with the use of tissue from human embryos. So far the tests are being done on mice.  “The two scientists say their next step will be to take this technology into large animal models of retinal degenerative disease and eventually toward human clinical trials.” Amniotic fluid health potion:  In a paper on PLoS One,1 Chinese researchers announced success deriving multipotent stem cells from amniotic fluid of pigs.  They were able to get these stem cells to differentiate into nerve, fat, and heart tissues without producing teratomas (tumors).  They said, “These optimal features of pAF-MSCs provide an excellent alternative stem cell resource for potential cell therapy in regenerative medicine and transgenic animals.”.  Even in China these researchers were aware of the controversy.  They said, “human amniotic fluid may be a new source of pluripotent stem cells without any ethical concerns associated with human embryonic stem cells (hES cells) research.” Umbilical vein health potion:  Another paper in PLoS One by the Salk Institute showed success at getting induced pluripotent stem cells from human umbilical vein endothelial cells.2  Their process was “rapid and highly efficient,” they reported, and produced stem cells that were “indistinguishable from human embryonic stem (ES) cells with regards to morphology, pluripotent marker expression, and their ability to generate all embryonic germ layers in vitro and in vivo.” Progeria find-and-replace:  An exciting discovery at Salk Institute shows the potential of adult stem cells to do “find and replace” operations on diseased genes, such as those with progeria, a degenerative disease that causes premature aging.  PhysOrg explained the process: The gene-targeting approach developed by Suzuki and his colleagues relies on the use of so-called helper-dependent adenoviral vector to deliver large mutation-free DNA molecules into cells.  Once there, these replacement pieces initiate a process known as homologous recombination, which works a bit like the “find-and-replace” command in a word processor.  If a piece of DNA is long enough, it will find and line up with the same sequence in the genome and swap places.     “The process was remarkably efficient and we couldn’t detect any undesired off-target effects such genomic instability or epigenetic abnormalities,” says Liu.  “What’s more, it allowed us to show that we can correct multiple mutations spanning large genomic regions.” The team used adult mesenchymal stem cells and iPS cells from progeria patients to test the genetic editing procedure.  The article said that these cells have been shown to differentiate into a wide variety of tissues, including “adipocytes, osteoblasts, chondrocytes, cardiomyocytes, adipocytes, and, as described lately, beta-pancreatic islets cells.” Regeneration takes a village of cells:  Don’t expect to grow a new arm with stem cells.  In an article on Science Daily, researchers at the Washington University School of Medicine in St. Louis found that, at least for zebrafish, multiple cell types are needed to regrow a lost fin. Crop yields:  Plants have stem cells, too – and not just in their stems.  Researchers at Texas Agrilife Research are studying stem cells in Arabidopsis to learn how to make plants produce more fruit, seeds and leaves, according to PhysOrg.last_img read more

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SA’s R80bn methane project

first_imgNT Energy UK, its empowerment partner Bataung Oil and the state-owned Central Energy Fund are to begin exploration for coalbed methane reserves as part of a project to develop sustainable sources of alternative energy for the country.Engineering News reported last week that GascoSA, which is exploring for the gas in three South African provinces, could be in commercial methane production in 18 months, spending US$169-million (about R1.1-billion) by the end of that period.GascoSA is 60% owned by NT Energy Africa, which comprises NT Energy UK and local empwerment company Bataung Group, and the state-owned Central Energy Fund (CEF).According to its website, CEF is involved in the search for appropriate energy solutions to meet the future energy needs including oil, gas, electrical power, solar energy, low-smoke fuels, biomass, wind and renewable energy sources.It also manages the operation and development of the oil and gas assets and operations of the South African government.According to BuaNews, the project, which is endorsed by the Department of Minerals and Energy as part of its mandage to secure energy for the coutry, represents a potential investment of U$10-billion over the next seven to 10 years in infrastructure and a pipeline rollout.Bataung Group chairman Billy Modise said that for the country to meet its development and job creation targets as outlined by the Accelerated and Shared Growth Initiative for South Africa (Asgi-SA), developing a sustainable source of alternative energy had become non-negotiable.“The development of sustainable sources of alternative energy has become a strategic priority for South Africa, especially as current demand continues to outstrip capacity,” Bataung Group MD Kinesh Pather told BuaNews. “Coal bed methane and the conversion of gas to liquid fuels provide a real, clean and long-term alternative to the current energy crisis.”NT Energy official Chris Mumby told Mining Weekly Online last week that the company had spoken informally with state-owned electricity utility Eskom about methane uptake, while it was also open to partnering with independent power producers.According to Engineering News, studies to reveal gas content would be completed by the middle of 2008, and viability studies by the fourth quarter of the year. If viable reserves are found, production drilling would take a further year.last_img read more

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Durant helps Warriors pull away over Nuggets

first_imgThe Nuggets, trailing by 13 after the first quarter, scored 15 straight points to start the second behind their bench players and moved in front for the first time in the game on Barton’s fastbreak 3-pointer 38-36 midway through the period. But Golden State came back to lead 60-55 at the half, scoring nine of the last 13 points in the final two minutes of the quarter capped by Thompson’s 3-pointer off a feed from Curry an instant before the halftime buzzer sounded.Golden State, showcasing its transition game and ball movement throughout the game, finished with 37 assists, including a game-high 11 by Curry.TIP-INSWarriors: G Shaun Livingston was inactive for the game as part of a designated rest day. … F Damian Jones, the Warriors’ first-round pick, is on assignment with the team’s G League squad in Santa Cruz and could be there for a awhile. “He’s going to spend a lot of time down there because there’s no point in him coming up here and sitting on the bench,” Coach Steve Kerr said prior to the game. “He needs to play. I could see bringing him up once in a while and giving him some playing time if we had an injury or something but for the most part he needs to play.”Nuggets: F Juancho Hernangomez remains sidelined because of a bout of mononucleosis. He has missed the past eight games. … Michigan State coach Tom Izzo was in attendance to see a pair of his former Spartan stars — Nuggets guard Gary Harris,who started 67 of his 68 career games under Izzo, and Warriors forward Draymond Green, a native of Saginaw, Mich. who helped the Spartans to two Final Four appearances.ADVERTISEMENT Kammuri turning to super typhoon less likely but possible — Pagasa John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Don’t miss out on the latest news and information. LATEST STORIES Towns leads Timberwolves past floundering Mavericks Protesters burn down Iran consulate in Najaf PLAY LIST 01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Will Barton had 21 points off the bench to lead the Nuggets. None of Denver’s starters reached double figures in scoring.Up by five at halftime, the Warriors forced a decisive turn in the game with a 24-4 run to start the third, taking an 84-59 lead when Curry hit a fall-away 3-pointer from the baseline after poking the ball away from Mason Plumlee for a steal.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutThe Warriors finished with 43 points in the third — the most points allowed by the Nuggets in a period this season — and took a 103-76 lead into the fourth quarter. Durant had 13 of his points in the period and Curry added 12 in the same span, helping Golden State lead by as many as 29 points and outscore Denver by 22 points in the quarter.Both teams began to substitute freely early in the fourth quarter and the Warriors coasted to the victory. Stronger peso trims PH debt value to P7.9 trillion MOST READcenter_img CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA QC cops nab robbery gang leader, cohort Typhoon Kammuri accelerates, gains strength en route to PH Read Next Japan ex-PM Nakasone who boosted ties with US dies at 101 Will Barton #5 of the Denver Nuggets has his shot blocked by Kevin Durant #35 of the Golden State Warriors at the Pepsi Center on November 4, 2017 in Denver, Colorado. AFPDENVER — Kevin Durant scored 25 points, Stephen Curry had 22 and the Golden State Warriors rode a big third quarter to a 127-108 victory over the Denver Nuggets on Saturday (Sunday Manila time).Klay Thompson and Draymond Green added 15 points apiece for the Warriors. They have won six of their last seven, including all three during their just concluded trip.ADVERTISEMENT Brace for potentially devastating typhoon approaching PH – NDRRMC View commentslast_img read more

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Japanese top countrys maiden Sports Climbing World Cup

first_imgMumbai, May 16 (PTI) Japanese climbers dominated at the maiden Sports Climbing World Cup held in Navi Mumbai over the weekend, accounting for four of the six podium slots. Japanese national Kokoro Fujii finished first in the mens bouldering category, while his compatriot Miho Nonaka bagged the top honours in womens bouldering. This was the first time that the International Federation of Sports Climbings World Cup (IFSC) was hosted in the country, which has a very nascent climbing scene at present. Supported by an enthusiastic crowd that cheered at every move, Fujii completed three of the four routes, while Nonaka cleared two of the womens routes. Other podium finishers from Japan included Tomoa Narasaki (second in mens category) and Akiyo Noguchi (third in womens category). A total of 80 athletes from countries like the US, Canada, France, Russia, Slovakia, South Korea and Iran, among others competed for the top honours. It also included 18 Indians but none of them could qualify beyond the first round.Elimination rounds were held on Saturday and it was wrapped up yesterday with the semi-finals and finals. The routes became difficult with every round and there were a lot of overhangs that made the climbers defy gravity with sheer power that was appreciated by a cheering crowd.The world cup was organised by the city-based Girivihar Adventure Club and hosted by the apex Indian Mountaineering Foundation.Sports climbing is set to be included in the 2018 Jakarta Asian Games and possibly in the 2020 Tokyo Olympics as well.”Climbing is a growing sport in the country and we would like to encourage more people to take up the sport and also come and watch such events. We will be looking to build on this platform,” Girivihars Franco Linhares said.advertisement”I know that it was not an easy journey but all credit to them (organisers) for pulling off a very well conducted world cup. I hope that this is only the beginning and we are able to bring many more such events to our country,” IFSC president Marco Maria Scolaris said. PTI AA BEN NRB AH AHlast_img read more

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25 days agoRudi Garcia lined up for AC Milan move

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Rudi Garcia lined up for AC Milan moveby Paul Vegas25 days agoSend to a friendShare the loveRudi Garcia is being lined up for a return to Italy.The former AS Roma coach is available after being forced out of Olympique Marseille last season.And Gazzetta dello Sport says Garcia is wanted by AC Milan.After their defeat to Fiorentina, Milan coach Marco Giampaolo is under great pressure. Indeed, defeat to Genoa this week could see him axed.And among those contacted by intermediaries about the job is Garcia.Milan is currently sitting in 12th place in Serie A. last_img read more

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Microsoft hires former Siri boss for AI leadership role

first_imgSan Francisco: The former head of Apples Siri division Bill Stasior, is leaving the company after nearly a decade to join Microsofts artificial intelligence (AI) division. Stasior left Apple in May and he is joining Microsoft later this month as a corporate vice president, reporting to Chief Technology Officer Kevin Scott, The Verge reported on Monday. Stasior announced his job change by updating his resume on his personal website. He was vice president for AI and Siri when he left in May, according to his resume. According to his LinkedIn profile, from 2012 to 2019, he headed the 11,000-strong team of developers, scientists, product managers and designers working on Siri. Before Apple, Stasior was one of the top executives at Amazon. In addition, he previously worked at AltaVista and Oracle.last_img read more

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Hasnt campaigned with federal leader NDPs Notley says her focus on Alberta

first_imgCALGARY — Alberta NDP Leader Rachel Notley says she hasn’t campaigned with the federal party leader because her focus is on what’s best for the province — including pipelines.During a campaign stop in Calgary today, Notley was asked about a Thursday rally with federal Conservative Leader Andrew Scheer and Alberta United Conservative Leader Jason Kenney.They attacked what they call the “Notley-Trudeau alliance.”Notley said the Kenney-Scheer rally makes her wonder if Kenney is even interested in standing up for Albertans.She questioned whether he’s trying to get back into the ring in Ottawa for his own political purposes.Notley said her job is to stand up for the people of Alberta rather than align with federal NDP Leader Jagmeet Singh.“As you know, I don’t necessarily agree with the leader of our federal party as far as how that connects with the matter of pipelines,” she said. “So, no, we are not going to campaign together because we have two very different opinions on the issue.”The Canadian Presslast_img read more

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The Thunder May Have Just Discovered an Amazing New Lineup

In the third quarter of Oklahoma City’s Thursday night win over Los Angeles, Thunder coach Scott Brooks, long maligned for doing the same old thing, discovered something new: a lineup of Nick Collison, Steven Adams, Kevin Durant, Russell Westbrook and Reggie Jackson could bend the court to its will.The group had rarely played together before — just six minutes during the regular season and just seven minutes in the playoffs. But that didn’t seem to be a problem. Over the next 15 minutes of play Thursday night, they scored 42 points and allowed just 24 points on 41 percent shooting, turning a 7-point deficit into an 11-point lead. Extrapolated to a 100-possession pace, the lineup’s point differential was +64.3.Small sample size, of course, but whoa, what a sample. The Thunder’s most-played lineup in the regular season (with Jackson in place of an injured Westbrook) had a per-100-possession point differential of +5.8. If we look at just the Thunder’s most frequently used front-court pairing, Kendrick Perkins and Serge Ibaka, we find a per-100-possession point differential of just +2.0.Something about the fresh lineup on Thursday spaced the floor for Durant to do his best work of the night, scoring 13 points on just six shots. Neither Collison nor Adams is a particularly dangerous offensive player, but they are both good offensive rebounders. When they were on the floor together for 494 minutes in the regular season, the Thunder rebounded 33.4 percent of their own misses, compared to 26.5 across the whole season. Collison and Adams can also set screens and roll hard to the basket, allowing the Thunder to spread the defense even without a great perimeter-shooting big guy on the floor.Durant has played just a small percentage of his minutes with a Collison-Adams front-court pairing this season, but he’s been remarkably effective when he does, netting his highest true shooting percentage.Front Court Combinations Playing With DurantIt’s hard to suss out whether playing this group together  was a shrewd and intentional move by Brooks, or whether he stumbled upon the lineup after Ibaka’s calf injury. But it’s an important development as the Thunder get ready for the San Antonio Spurs. Going into Thursday night’s game, seven of the Thunder’s 10 most-used lineups in the playoffs had a positive point differential. With the emphatic arrival of this group, it’s now eight of 10.Lineups matter especially for the Thunder, a team whose starting five tend to start slowly. That group finished the series with a negative first-quarter point differential and was outscored to begin four of the six games in the series. Inserting Collison and Adams into the starting lineup is probably not the solution to those slow starts, but the Spurs are waiting with a deep and versatile matchup nightmare. Every opportunity Brooks has to experiment with a seldom-used but potentially explosive lineup gives him more options to handle the varied scenarios the Spurs will throw at the Thunder. read more

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Michigan born OSU hockey forward Nick Schilkey wears scarlet and gray close

OSU junior forward Nick Schilkey (7) during a game against Michigan on May. 6 at Nationwide Arena. Credit: Lantern File PhotoOhio State senior forward hockey captain Nick Schilkey wishes he had a dollar for every time he has been asked why he came to OSU from his home state of Michigan. If so, he said he would be as rich as another Buckeye: L Brands owner Les Wexner. The constant questioning will be worth it, however, if Schilkey is successful in his pursuit of a Big Ten championship and the program’s first berth into the NCAA tournament since 2009.  A native of Marysville, Michigan, Schilkey grew up playing in the Detroit area primarily with the nationally recognized HoneyBaked AAA program. It was his parents, Glen and Michelle, along with his other family ties that instilled the love for the game of hockey in him.“My dad always joked that he put me in skates before I could walk.” Schilkey said.His speed and agility — which led him to score 87 goals and assist on 85 others between the ages of 13 and 16 against NHL players Alex Galchenyuk of the Montreal Canadiens and Jacob Trouba of the Winnipeg Jets — caught the attention of OSU.It was not until his final year with HoneyBaked in 2010-11 that he realized college hockey was a legitimate option.“I don’t think I could ever look back at one of those teams and thinking to myself as being one of the best guys because we were so good,” Schilkey said.OSU was the first school to approach Schilkey about furthering his career in hockey. The program’s commitment to Schilkey, facilities and campus life sold him immediately, he said.“I go to different schools around the country and play and nothing beats what we have here,” Schilkey said. “I came down here and the coaches really wanted me to be here and I wanted to be here. This was the spot for me.”Before he moved to Columbus, Schilkey played junior hockey for two years, a common prerequisite for hockey players before beginning their college endeavors.After two seasons with the Green Bay Gamblers of the United States Hockey League, the top junior league in the U.S., Schilkey was ready to showcase his talents at OSU.The team he was recruited by, however, had changed by the time he arrived. In April 2013, OSU coach Mark Osiecki was fired and replaced by Steve Rohlik, who had been an Osiecki assistant.Schilkey was not deterred.“I was comfortable with the coaches because (Rohlik) was here,” Schilkey said. “For me, I didn’t think anything would change too much.”Rohlik recalled the recruitment of Schilkey, who stood out like maize and blue in a sea of scarlet and gray.“When you walked into the rink, you knew who Nick Schilkey was,” Rohlik said. “He’d get that puck and he’d be Mach 10 down the ice. He could score. One thing that always grabbed me is that he wanted it. He wanted the puck, he wanted to be involved, he wanted to be ‘the guy.’ There was no hesitation in his game.”Rohlik has continued to be impressed by Schilkey’s performances weekend after weekend.“You know what you’re getting when he touches the ice,” Rohlik said. “I know if I throw him out there, he’s going to give me everything that he’s got.”And it shows in his production, Rohlik said.In 108 career games, Schilkey has 43 goals and 48 assists. He has been voted team captain twice due to leadership that has rubbed off on his teammates.“Right away freshman year, I noticed that he never quits,” senior defenseman Josh Healey said. “He goes out there every shift and every time in the weight room and goes until he can’t go anymore. It really pushed me to be my best when I was around him … He’s a leader by example and guys follow that, it’s a credit to him.”So far this season, the team has followed him to an upset win over No. 3 Denver last Friday on its home ice, followed by a tie with Air Force the next night. As the Buckeyes head into the heart of the 2016-17 season, Rohlik said there is no one he would trust more to lead the team.“I think it’s in him right now that he wants to do something special before he leaves here,” Rohlik said. “He’s already had such a huge impact on this program, not only by being a great player, but by being a great person. I can’t say enough about him. He’s one of those guys, as a coach, you love having him in your program.” As for Schilkey, the legacy he wants to leave behind is a championship in his home state. The conference tournament will be hosted at Joe Louis Arena in Detroit for the final time in March.“To get this team back there and obviously it’s going to take a lot of leaders in the room, it’s going to take the team to accomplish that goal,” Schilkey said. “I think we’re excited for it. I think we’re confident in that this is one of the best opportunities we’ve had in my four years here. To leave on top is something everybody wants to do.”Ranked No. 19 in the latest uscho.com poll, Schilkey and the Buckeyes head to Oxford, Ohio, on Saturday to take on in-state rival Miami at Goggin Ice Center with the puck drop scheduled for 8:05 p.m. read more

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Undefeated Ohio State football finishes 120 in Urban Meyers first season

For all intents and purposes, the 2012 Ohio State football senior class is gone, never to wear scarlet and gray in meaningful competition again. “It’s almost like you’re losing some of your children when they go away to college,” said first-year OSU coach Urban Meyer after the team’s season-ending win against Michigan on Saturday. “Our house is going to be empty.” Gone? Perhaps, but not to be soon forgotten. After all, it was the contributions of the seniors that made the team’s run at perfection a possibility. Behind the strength of many of those 21 departing seniors, the No. 4-ranked Buckeyes (12-0, 8-0 Big Ten) clinched the sixth undefeated and untied season in program history and the first since 2002 Saturday with a 26-21 win against archrival Michigan (8-4, 6-2 Big Ten) at Ohio Stadium. The 109th edition of The Game saw OSU, the Big Ten’s Leaders Division champions, claim its 44th win against the Wolverines. UM, eliminated from Big Ten title contention after Nebraska beat Iowa on Friday, still owns the all-time series advantage with a 58-44-6 record. With Saturday being the final game of the season due to the NCAA-imposed postseason ban, one thing was evident within minutes of the final whistle following victory against UM – no more seniors. Meyer handed out several “thank you’s” during his postgame remarks, but the biggest thank you went out to those whose eligibility is up, players like Zach Boren, Etienne Sabino and John Simon. Theirs was an effort worthy of remembrance, Meyer said, and he plans to ensure that their memory doesn’t fade away. “I’m going to see to it when you walk into that Woody Hayes (Athletic Center) this team will never be forgotten, because they deserve that,” he said. It’s not hard to imagine why Meyer feels so strongly. Boren switched positions midseason, jumping from offense to defense when he left the fullback spot to join a depleted line backing corps. Boren hadn’t played linebacker since high school but, in just six games, he tallied 50 tackles, including a team-high nine in the win against UM. One of those tackles was a bone-jarring sack of Wolverines junior quarterback Devin Gardner. Boren stood above Gardner after the hit, shouting and rattling his face mask just above Gardner’s. Sabino broke his leg during OSU’s Oct. 6 win against Nebraska but returned in time to join the team for its divisional-clinching win against Wisconsin on Nov. 17, as well as the game against the Wolverines. The redshirt senior linebacker said the 2012 season was indeed a dream. “I wouldn’t want it to end any other way,” he said. And there was Simon, a defensive end and the team’s emotional leader throughout the perfect campaign. Simon missed Saturday’s Senior Day activities, as well as the game itself, with a right knee injury sustained one week prior against Wisconsin. “John Simon – the heart and soul of who we are as the 2012 football team,” Meyer said. Simon was not made available for comment following the game. There were other major contributors from the senior class, relatively unheralded compared to Boren, Sabino and Simon, but whose contributions likely went just as far in helping the team achieve an undefeated season. OSU redshirt senior punter Ben Buchanan walked off the Ohio Stadium field for the final time at peace with what he gave to the program. His final play was a 41-yard punt that pinned UM on its 8-yard line with less than 10 minutes to play in the game. Given the moment, Buchanan said, the punt was as good as it gets. “I think this team will be remembered as a very unselfish team, a team that really had to come together with some tough circumstances, there’s no doubting that,” Buchanan said. “I was proud of the way these guys just rallied and, they did, we just refused to lose and to be a senior on this team was truly on honor.” Sensing that he wouldn’t fit in Meyer’s offensive system, OSU senior Reid Fragel went to his then-newly hired coach and volunteered to switch from tight end to right tackle. For his selfless act, Fragel was plunged into a preseason battle for playing time with freshman Taylor Decker, which Fragel later won. Months later, Fragel attempted to address his teammates in the locker room following the season-ending win against the Wolverines. He struggled to articulate he feelings. “I wanted to thank (my teammates) and, really, tell them how I feel about this whole year, but it’s hard to put words to this season we’ve had,” Fragel said. “It’s something out of a movie … Just to see us come out 12-0, beating Michigan, that’s something I couldn’t have wrote up before the game.” As Buchanan and his teammates enjoyed the climactic day of the season, OSU football converged with its troubled past as former coach Jim Tressel, the man responsible for the 2012 team’s postseason ban, returned. Once shamed by the “Tattoo-Gate” scandal in which he knowingly fielded a team of ineligible players during the 2010 season, Tressel was hoisted onto the shoulders of players from his 2002 national championship team, which was honored for the 10-year reunion of its great feat between the first and second quarters. But with Tressel came memories of his unceremonious exit from the university – he was forced to resign in May 2011 – as well as the Buckeyes’ agonizing 2011 campaign where they posted a 6-7 record. The loudest cheers during Saturday’s short, in-game ceremony for the 2002 team came during the moments that featured Tressel, the man that each member of the 2012 senior class signed on to play for. Louder still were the cheers for the current players themselves, now under Meyer’s direction, during actual game action, and particularly when the clock struck “00:00.” Meyer will hold a “season wrap-up” press conference on Monday, according to an OSU athletics release. The Buckeyes will then turn the page on the 2012 season and set their sights on 2013. “After our team meeting on Tuesday, we start a new journey,” Meyer said. The strong foundation that has been laid at OSU exists because of the 21 dedicated Buckeyes that hung up their pads and cleats for the final time on Saturday. For those seniors who won’t rejoin the Scarlet and Gray in pursuit of championship glory, their last gasp as active members of the Buckeye Brotherhood couldn’t have been sweeter. “It’s unbelievable, man, I couldn’t ask for anything more other than a chance to play a couple more weeks,” said OSU redshirt senior defensive lineman Nathan Williams. “This is how the 2012 team is going to be remembered by, you know, going undefeated … going 12-0 and beating Michigan at home. I really wouldn’t want to go out any other way than that.” read more

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Kent States Darrell Hazell rumored to be headed to Purdue

Kent State’s Darrell Hazell might become Purdue’s next football coach, according to multiple reports Tuesday. After guiding the No. 25 Golden Flashes to an 11-2 mark this season, Hazell is reportedly the Boilermakers’ first pick to replace former Purdue coach Danny Hope, who was fired Nov. 25, after going 23-27 in four seasons. Hazell led Kent State its first winning season since 2001 – a feat that earned the second-year coach the Mid-American Conference Coach of the Year. The potential move to West Lafayette, Ind., though, could bring him back to his old stomping grounds in the Big Ten. From 2004 to 2010, Hazell served as an assistant under former Ohio State coach Jim Tressel – first as the team’s wide receivers and kick returns coach before becoming the Buckeyes’ assistant head coach and wide receivers coach. Cincinnati’s Butch Jones has reportedly also been in talks with Purdue about their coaching vacancy. According to multiple media outlets, the Boilermakers are expected have a decision by Wednesday. After losing to Northern Illinois in overtime, 44-37, in the MAC Championship Game Saturday, the Golden Flashes are set to face Arkansas State in the GoDaddy.com Bowl on Jan. 6 in Mobile, Ala. read more

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North County teen jailed for alleged online threat of campus violence

first_img OCEANSIDE (KUSI) – A 17-year-old Mission Vista High School student was in custody Friday following his arrest on suspicion of posting a vague but ominous online statement insinuating the North County campus was about to be targeted by violence.The Oceanside Police Department received a report about the alleged Snapchat threat about 7:30 p.m. Thursday, OPD spokesman Tom Bussey said.The message warned students to stay away from the Melrose Drive school Friday and included a photograph of the suspect along with the statement “the cleansing shall commence.”Officers contacted the teen at his Vista home and took him into custody later in the evening, Bussey said.The suspect, whose name was withheld because he is a minor, was booked into juvenile hall on suspicion of issuing a criminal threat.The incident prompted an increased police presence in the area of the campus Friday morning and afternoon, according to Bussey. May 10, 2019 KUSI Newsroom, North County teen jailed for alleged online threat of campus violence Posted: May 10, 2019 KUSI Newsroom Categories: Local San Diego News FacebookTwitterlast_img read more

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IndiGos poor customer care record forces parliamentary panel to flag airline

first_imgThe alleged failure of IndiGo to respond satisfactorily to customer complaints is behind a parliamentary panel’s remarks that it is the ‘worst performing’ airline for customer services.Derek O’Brien, the Trinamool Congress MP who heads the panel, reserved the sharpest criticism for the low-budget carrier in a report that he tabled in the Rajya Sabha, according to a media report.The Parliamentary Standing Committee on Transport, Tourism and Culture, Road, Shipping and Aviation said in the report that the airline was noted for poor customer services, having rude staff and higher charges during the festive season, among other issues.IndiGo, owned by InterGlobe Enterprises, however, denied it neglected customer complaints. The airline said in a statement that it evaluated complaints and feedback by the customers rigorously and the staff were given regular training to handle situations and make possible hassle-free customer experience.O’Brien said the panel was not generally happy with the way some private carriers are operating, but it was discourteous the way IndiGo was operating. He said Air India had the best luggage policy.”Our committee is very clear that the worst performing airline for consumers is IndiGo. All 30 members agreed on this. IndiGo has not respondeddespite many complaints. The way they behave with consumers and charge for just one kg or two kg overweight of air baggage…,” O’Brien said, according to a media report.He said some carriers charged eight to 10 times the normal fares during the festive season.”The airline is very rigid, IndiGo even charges for one-two kg overweight, this has not been taken very well and the committee is looking into the matter seriously,” O’Brien said.While taking note of higher fare charges, the panel suggested that the charges by the airlines should not exceed 50 per cent of the base fare and tax and airlines should refund the fuel surcharge to customers.The national carrier Air India has the best policy for luggage and other private carriers should raise the baggage limit, O’Brien said.last_img read more

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Protein lifetime and the stability of cell structures

first_img(Phys.org) —The ability of a cell to move, replicate, and recast itself according to the needs of the organism which it serves, comes at it price. The extreme flexibility of cells takes its origin from the constant turnover of nearly every component with which they are made. There are a few exceptions to this general principle for a few protected regions like, for example, the lens of the eye, or the collagen matrix within the extracellular space. In a new paper published in Cell, researchers show that certain components of the pore complex that controls the flow of components out of the nucleus, escape the normal turnover cycle, and may persist for the lifetime of the cell. Some Nuclear pore complex proteins can last for the lifetime of the cell. Credit: learn.genetics.utah.edu More information: Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures, Cell, Volume 154, Issue 5, 971-982, 29 August 2013. DOI: 10.1016/j.cell.2013.07.037AbstractIntracellular proteins with long lifespans have recently been linked to age-dependent defects, ranging from decreased fertility to the functional decline of neurons. Why long-lived proteins exist in metabolically active cellular environments and how they are maintained over time remains poorly understood. Here, we provide a system-wide identification of proteins with exceptional lifespans in the rat brain. These proteins are inefficiently replenished despite being translated robustly throughout adulthood. Using nucleoporins as a paradigm for long-term protein persistence, we found that nuclear pore complexes (NPCs) are maintained over a cell’s life through slow but finite exchange of even its most stable subcomplexes. This maintenance is limited, however, as some nucleoporin levels decrease during aging, providing a rationale for the previously observed age-dependent deterioration of NPC function. Our identification of a long-lived proteome reveals cellular components that are at increased risk for damage accumulation, linking long-term protein persistence to the cellular aging process. The ‘weakest link’ in the aging proteome Journal information: Cell Extracellular proteins, like crystallins of the lens, or components of cartilage, accumulate damage over time that compromises their function. Clouded vision or stiff joints are the familiar result. Inside cells however, an intricate accounting system exists whereby proteins are stochastically festooned with sequential markers for degradation—much like a trainee might predictably progresses through the colored ranks of Karate. In yeast, it has been reported that the average protein half-life is just 90 minutes, while for mammals it may be more like 1 or 2 days.An exception to this rule is our DNA, which owes its long life to dedicated repair mechanisms that patch up damage. For proteins however, no such sequence-level mechanisms are known to exist. The histone proteins that bind DNA have also been observed, in some cases, to be exceptionally long-lived. Measuring these lifetimes reliably, particularly for the older generation, requires some special experimental considerations. The researchers used a method called pulse-chase labeling, which requires feeding newborn rats a diet containing exclusively the 15N isotope as the pulse. A normal 14N diet, the chase, was begun after 6 weeks, and the animals then sacrificied at various times over the ensuing year. The cellular components were then fractionated and mass spectrometry was used to comprehensively identify long-lived proteins in the brain. The lifespans of a few components of the nuclear pore complex (NPC) were particularly striking. The NPC contains multiple copies of over 30 different subvarieties of the nucleoporin (Nup) family alone. Two particular subcomplexes of Nup proteins, which serve as scaffold components, where found to resist degradation. The researchers also measured translation levels of these and 11,000 other proteins to measure synthesis levels concomitantly. Every long-lived protein was found to also be actively involved in translation.Unlike other large protein complexes, such as ribosomes or proteasomes, the NPC apparently does not turnover as an entire complex. Instead individual subcomplexes are exchanged at specific rates as new copies are synthesized. What mechanisms might administer this exchange, if any, are as yet unknown. The researchers found, in particular, that 25% of those proteins within a certain complex (Nup205), have not been replaced after a year. Together with the histone H3.1 protein, that stat earns them the title of most persistent mammalian intracellular protein. The authors speculate that disassembly of entire NPCs might not be practical for the cell because dismantling these key components could jeopardize the integrity of the nuclear envelope. Important nuclear substructure, possibly including epigenetic depots critical for transmitting information beyond the lifetime of an individual cell might then be compromised. They also note that long-lived proteins might also be sources of vulnerability within the proteome, particular those that would be exposed to harmful metabolites or chemical interlopers. Identification of these elements may therefore be important in understanding the aging process in postmitotic cells.center_img Citation: Protein lifetime and the stability of cell structures (2013, September 4) retrieved 18 August 2019 from https://phys.org/news/2013-09-protein-lifetime-stability-cell.html Explore further © 2013 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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Centre Serves Up Gold Medal High Tea

first_imgThe Sydney Convention and Exhibition Centre’s inspired high tea has won gold at the Dilmah Real High Tea Challenge in Sydney.The Centre was one of only two venues to be given a gold award after brewing up a storm against some of the city’s best-known high tea establishments in last week’s New South Wales challenge.Centre Chief Executive Ton van Amerongen said the Centre prided itself on the high tea served in its waterfront Bayside Lounge, which was recently ranked one of Sydney’s top 10 high tea offerings by Time Out magazine.“It’s wonderful to see our culinary team’s creativity and flair earn them gold in this competition,” Mr van Amerongen said.Centre Executive Chef Uwe Habermehl and Sommelier William Wilson created a delicious high tea for the Challenge, consisting of four different Dilmah tea drinks and a range of sweet and savoury offerings, such as peach tea and pumpkin macaron with leatherwood honey filling, served with Dilmah Berry Sensation iced tea made with sparkling rain water. Source = Sydney Convention and Exhibition Centre High Tealast_img read more

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Vadim Fedotov Russian pay TV provider NTV is laun

first_imgVadim FedotovRussian pay TV provider NTV+ is launching an internet-connected hybrid set-top that will enable it to offer interactive TV services including video-on-demand, pause live TV and catch-up TV.Gazprom Media-owned NTV+’s box is a joint project between the pay TV outfit and its parent company’s technology arm. The device will be manufactured by Korea’s Kaonmedia with NTV+ branding.The UI of the new set-top is currently undergoing testing and development ahead of a planned November launch, according to NTV+.The new UI will allow subscribers to browse channel, order movies and manage their subscriber account as well as create a list of favourite channels.NTV+ CEO Mikhail Demin said that sales of the new box will kick off in Novmeber. He said he expected the hybrid device to account for 10% of all new box sales from launch, growing to up to 50% by the end of next year, depending on market conditions.Demin said that the trend towards consumption of OTT TV services was likely to accelerate and that the launch of a hybrid box would give the operator an opportunity to grow its base.Gazprom Media Technology CEO Vadim Fedotov said that the launch was an important step towards creating a personalized TV experience for subscribers. He said the UI would provide access to standard broadcast, on-demand and catch-up content, including exclusive premieres. Fedotov said the OTT element of the service would be further developed in the future.last_img read more

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Interviewed by Louis James Editor International

first_img(Interviewed by Louis James, Editor, International Speculator) L: Marin, it’s been a long time since we asked you for an update on energy markets, which are your specialty. Given all that Doug says is coming down the pike, what do you see ahead, and how does one invest? Marin: I think that for the most part, we’ll see a continuation of what we’ve seen for the last 18 months… L: That’s not an encouraging thought. Marin: Maybe so, but that’s the reality of what I see in the markets, especially when it comes to the juniors. There are a lot of subsectors of the energy markets for which I’ve been telling people to stay away from the juniors for at least 18 to 24 months. Thermal coal is an example. I’m glad we’ve stayed away, as the thermal-coal companies have become massive destroyers of wealth. L: Can you elaborate on that? We still need coal, so why aren’t the current low prices a “buy low, sell high” setup? Marin: Well, there are two factors to consider. First, as I mentioned on national TV about two years ago, permitting coal projects – not just for production, but even for exploration – was going to become very, very difficult… especially in North America. L: All these people up in arms about “mountaintop mining” and such? Marin: Exactly. The reality is that nobody wants a coal mine in their back yard. This affects both thermal and metallurgical coal projects, but the two face different market dynamics. Met coal got slaughtered because of decreased steel manufacturing, while thermal coal got slaughtered because of the competition from natural gas. Still, both saw lower prices, and in an environment of much more difficult and expensive permitting, the companies are getting trashed. L: And the second factor? Marin: That’s the new carbon tax the Obama administration is pushing. Believe it or not, the oil companies are actually supporting it. L: Why on earth would they do that? Marin: Because many of them are not just oil companies. A company like Exxon is as much a gas company as it is an oil company, and they’re having a hard time competing with the national oil companies on the global market. So, they’ve come home and are buying up large reserves of natural gas, making a heavy commitment to North American natural gas. So it’s in their interest jump on the Obama bandwagon and increase taxes on coal to benefit their gas investments in North America. L: Politics as usual. Got it. So, we keep staying away from coal, especially thermal coal. What about uranium? That’s been in the news a lot lately as well, with Japan doing an about-face on its nuclear program. Marin: Yes, the new president of Japan basically stated that Japan has no choice but to bring its reactors back online. But it’s not going to happen as quickly as the market wants it to happen, so while we’ve made good money on uranium plays in the last few months – and I’m very bullish on uranium – we’ve taken profits on our winners in our energy letters. We still have core holdings. Actually, we’ve written that we believe that Fukushima is the beginning of the fourth great bull market for uranium. With the Chinese, Russians, Koreans, and other countries committing to nuclear energy as part of their energy matrix, even after Fukushima the trend is very solid. By 2020, there’s going to be another 88 reactors online. And already today, the US imports over 90% of the uranium it consumes. To put that into perspective, consider that in 1960, the US was the world’s largest uranium producer. At the time, there were over 1,000 uranium mines in the US, producing over 36 million pounds of uranium every year. Today, there are eleven uranium mines, producing 3.4 million pounds a year. So America is producing less than 10% of what it produced in 1960, and yet is more dependent than ever on nuclear energy. One in every ten homes in America is powered by Russian uranium. L: Wow… I can see why you’re still bullish. What else do you like these days? Marin: One of the most interesting and powerful market dynamics I see today is the European addiction to Russian natural resources. That can’t change quickly, and there is a great potential for profit. The way we approach it in our letters is to ask ourselves how we can profit from the Putinization of Europe. It’s not just oil and gas, but uranium as well, and non-energy resources. We’ve found several profitable niches. L: Okay. But getting back to the original question, if Doug Casey is right about the Greater Depression gathering force this year, that would seem bearish for energy. How do you strategize for that? Marin: I think there’s a good chance Doug is right. So, in our newsletters, the first things we look at are management, cash, and expenditure programs in the specific jurisdictions the companies operate. We want companies that have a lot of cash, and will not need to go back to the market any time soon. From an equities standpoint in the resource sector, that’s the ultimate Achilles heel of most resource companies. The reality is that most are, as Doug likes to day, burning matches. L: Sure, but you don’t want companies that are just sitting on cash. Marin: Of course. We want companies that have the cash and the ability to advance a project that will deliver value. They need to have a project with technical merit, in a place where they can get it permitted – we use the same 8 Ps you do. Most important is that even if they do have the cash, get permitted, and drill a successful well, do they have the infrastructure to deliver that oil to the market and make money doing so? Energy is very different from mining. Certain wells are extremely expensive to drill, and you don’t really know what you’ll get until you do drill them. Once you do, you know right away if it worked out, what you have, and you can go into production if it all works out. Mining exploration is much cheaper, and the big capital expenditures don’t come until after you know what you have, and have done a feasibility study on it. L: I get it; a big mine can cost several billion dollars to build, but you can drill a grid of holes that outline an ore body for just a couple million bucks. Marin: Yes. A single oil well in Kenya can cost north of $65 million. L: $65 million! I can build a modest but significant gold mine for that much. Marin: Yes, you could build a 25,000 to 45,000-ounces-per-year gold mine for that. But on the positive side, when you make your discovery in the oil patch, the path to cash flow is very short and fast, so the impact on share prices can be explosive. That’s why I love energy stocks. L: Sure; the Casey team likes volatility. And I also see your point about infrastructure. With metals, if you have a concentrate that’s valuable enough – not to mention gold or silver doré bars – you can transport your product anywhere in the world. But if you’ve got a well that’s more gas than oil, and there’s no pipeline network in the area that can handle it, you’ve got a product you can’t sell. Marin: Exactly. L: Okay, let’s talk about political risk – “resource nationalism” being the bogeyman of the day. Where are your favorite places in the world to invest? Are you willing to pay a premium for the safer jurisdictions? Marin: That varies by sector and the type of commodity. Some places are not workable for uranium exploration, for example, even though they are good for other kinds of mineral exploration. So I’m very bullish on WISR uranium production in the US. That is a term we created, so readers will see it here first: Warm In-Situ Recovery. WISR has much lower cost of production than other in-situ recovery projects in the US, comparable to those in Kazakhstan, but with much better environmental standards. I think that’s going to be a strong trend to bet on over the next five years. I’d stay away from uranium plays in Europe, Africa, and South America – the risk is just too high. We’ve had a great run on the Athabasca Basin uranium plays, and having made our money, we’ve taken it back off the table. For oil-patch plays, I really like the East African Rift in Kenya. We were the first to recommend that area play. We’ve also taken profits there, but it’s very interesting what’s going on there. Those are large, world-class deposits being drilled off right now. I’m also very bullish on certain parts of Europe, where there are great, past-producing oil fields that have light, liquid-rich oil, but have not seen any modern exploration. And yet the people living in those places are paying a premium over global energy prices, because they are so dependent on imports from Russia and the Middle East. I’d warn people to be very careful about these junior Canadian oil companies that are chasing yield in the western sedimentary basin. I think there are a lot of risks associated with that, so there’s little room for error. Because of the differentials – investors have to remember that just because you get $90 a barrel for WTI, that doesn’t mean you’ll get the same for Canadian oil far from any distribution infrastructure – any bad news can be fatal. L: So what do you look for in that kind of situation? Very near-term Push? Focus on quick wins, rather than big wins? Marin: Yes. For example, we recommended Atico and PRD Energy at the Casey conference last September, and both have more than doubled since then. Anything we recommend has to have cash in the bank, management have to be the largest shareholders, and they have to go for assets that matter – can really move the needle, by delivering sustainable cash flow. Like you, we start with the People. That’s absolutely critical. L: Very good. Can you give us a sneak preview of what you’re working for upcoming publications? Marin: We have a lot going on. Right now we’re doing a complete analysis of the master limited partnerships and the American oil and gas sector, and a complete analysis on whether the US can actually become energy independent by 2035. I’ll also be publishing an interview with a former senior OPEC official I recently spoke with. Also, a trip to Saudi Arabia is in the works – there’s a lot in the pipeline. We’re looking at juniors in the right places, because that’s where the most volatility is – and the most potential for big profits. But if there is a big global economic pullback, most of these juniors don’t have a chance. It’s so capital intensive… A single ultra-deep oil well offshore can cost more than $100 million. The little guys won’t stand a chance if the market turns negative and stays there for a few years. Maybe one thing we should highlight is that the game has really changed. It’s become so much more expensive, and the big oil companies reserves are decreasing, because of the changing value of their BOEs. L: Not all oil equivalents are really equivalent to oil. Marin: Barrels of oil equivalent – BOEs – are the biggest scam in the energy sector today. They say they have a gas component of their production that’s equivalent to so many barrels of oil, but they don’t define what’s in that gas. Is it methane? Butane? Propane? Pentane? All of these have different and changing values. The SEC allows the companies to roll all of this up as “BOE,” but they are not all equal. And yet, many companies present their reserves as though their reserves were the same thing as oil. This is very important. L: How does the average investor know what the real value of a company’s BOEs are, then? Marin: They have to really dig down deep into the PV10s and other technical disclosures. You have to have the ability to understand these reports and to be willing to put in the time into doing so. This is, I’m proud to say, one of our Casey advantages; we do this for all our energy publications. Few others will put out net-back reports as we do. What matters is not how many BOEs companies produce, but what they get back for them after delivery to the market. I don’t mean to be negative, but a lot of people don’t get this; and, frankly, they’re screwed. L: That’s a technical term. Marin: [Chuckles] Yes. L: Very well, then; words to the wise. Thanks for the interview, brother, and stay safe out there. Marin: You’re welcome, and you too. L: Will do. Marin Katusa is chief energy investment strategist for Casey Research and the editor of two company newsletters on energy: Casey Energy Dividends, which focuses on low-risk dividend-paying energy stocks, and Casey Energy Report, which features junior energy exploration companies with huge profit potential. He also edits an elite alert service that covers fast-moving energy plays in the junior resource sector, Casey Energy Confidential.last_img read more

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Weve all seen the statistic since 1913 the doll

first_imgWe’ve all seen the statistic: since 1913, the dollar has lost 98% of its purchasing power. That means that roughly, you now need $50 to buy what you could have bought for just $1 a little over 100 years ago. But the media are obsessed with a strong dollar today. To counteract the hysteria, NPR reported a refreshing point: Commerce Secretary Penny Pritzker said in an interview Monday that on one hand, having a strong currency “is a reflection of the fact the U.S. economy is strong. … So that’s the good news.” On the other hand, “it would be naïve to say the strong dollar isn’t something that some companies are taking into account” and might make land and equipment too expensive here, she said. The key to overcoming that currency drawback is to be sure foreign investors see the big picture and understand the long-term value of the U.S. market, she said. “Your location decisions are ones made for decades” and should not be based on today’s currency bounces, she noted. The rising dollar has made US assets, equity included, more expensive. A stronger dollar also means it takes more foreign currency to buy goods priced in the USD. This is one reason CEOs often mention “currency headwinds” on earnings calls. That said, I agree with Ms. Pritzker. Taking a longer-term view on the dollar can benefit businesses and investors alike. And such a view offers a lot of food for thought: The chart shows the decline of the US dollar’s value relative to a basket of foreign currencies, including the euro, Canadian and Australian dollars, Japanese yen, British pound, Swiss franc, and Swedish krona. The 2014-2015 uptick looks impressive, no doubt, but the black trend line tells a different story: the dollar is no long-distance champ. This is why I discouraged investing in securities tied to the US dollar, such as Treasuries, in my last post. Despite its recent rise, the long-term value proposition of the world’s reserve currency looks unappealing. Stocks, however, will benefit from a weaker dollar in the long term, and this is why we keep looking for equity opportunities for the Money Forever Portfolio.last_img read more

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A federal judge in Texas issued a ruling Friday de

first_imgA federal judge in Texas issued a ruling Friday declaring the Affordable Care Act unconstitutional, apparently setting the stage for another hearing on the health care law by the U.S. Supreme Court.The ruling by U.S. District Judge Reed O’Connor invalidates what’s commonly referred to as Obamacare nationwide, and casts into doubt the survival of the law on the eve of the deadline for tens of millions of Americans to sign up for health care coverage in 2019.The ruling comes in a lawsuit brought against what was one of the major domestic achievements of the Obama administration. An alliance of 19 Republican attorneys general and a governor led by Texas Attorney General Ken Paxton challenged the law.As NPR’s Alison Kodjak explained on All Things Considered,”The lawsuit had to do with whether when Congress last year repealed or eliminated the penalty for not having insurance — it was a tax penalty for people who didn’t have insurance — whether that meant the rest of the law didn’t apply anymore. The court case argued that all of the pieces of the law were dependent upon each other, so by eliminating the penalty the rest of the law fell apart. The judge agreed with that opinion.”In his 55-page opinion, Judge O’Connor said the debate over the ACA’s interlocking provisions is “like watching a slow game of Jenga, each party poking at a different provision to see if the ACA falls.”In a statement, White House press secretary Sarah Sanders praised the ruling.”Obamacare has been struck down by a highly respected judge. The judge’s decision vindicates President Trump’s position that Obamacare is unconstitutional. Once again, the President calls on Congress to replace Obamacare and act to protect people with preexisting conditions and provide Americans with quality affordable healthcare. We expect this ruling will be appealed to the Supreme Court. Pending the appeal process, the law remains in place.”Shortly afterwards, President Trump tweeted, “As I predicted all along, Obamacare has been struck down as an UNCONSTITUTIONAL disaster! Now Congress must pass a STRONG law that provides GREAT healthcare and protects pre-existing conditions.”California Attorney General Xavier Becerra, who led the coalition of states that defended the ACA promised to continue the court fight to preserve the law.Rep. Nancy Pelosi, who is expected to be House speaker when Democrats come into the majority next month, tweeted, “Tonight’s absurd ruling exposes the monstrous endgame of the GOP’s all-out assault on people w/ pre-existing conditions & the ACA. When @HouseDemocrats take the gavel, the House will swiftly intervene in the appeals process to #ProtectOurCare!”Copyright 2018 NPR. To see more, visit https://www.npr.org.last_img read more

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A former care minister has suggested that the Libe

first_imgA former care minister has suggested that the Liberal Democrats might be in favour of reopening the Independent Living Fund (ILF).Norman Lamb (pictured), who was care minister in the coalition for nearly three years, told Disability News Service (DNS) that it was “intolerable” that former ILF-users were now facing cuts to their support packages, after the fund’s closure on 30 June.And he called on the government to act, potentially by reopening the fund.He spoke out after hearing from DNS how disabled campaigners were warning that “dangerous” cuts to support were now exposing government promises that former ILF-users would not lose out from its closure.ILF was run by the Department for Work and Pensions (DWP) and when it closed on 30 June was helping nearly 17,000 disabled people with the highest support needs to live independently.But the coalition government decided that it should be scrapped, promising instead that nine months’ worth of non-ring-fenced funding would be transferred through the Department for Communities and Local Government (DCLG) to councils in England, and to devolved governments in Wales and Scotland.The transition process has been hit by reports of delays in reassessments for former ILF-users and cuts to their care packages, and government pre-closure statements and pledges appear to be falling apart.Lamb was speaking to DNS two days after delivering a well-received speech to his party’s annual conference in Bournemouth, which highlighted the need to address a possible £5 billion funding shortfall in social care by 2020.He told DNS that the ILF principle was “one that I strongly support”, as it “enables people to determine their own priorities”.Lamb said he was concerned not only about former ILF-users, but also about many other disabled people who faced the “full, emerging, developing crisis in social care”.He said: “I think the government needs to recognise what is actually happening… look closely at the evidence and act on it.“What would be intolerable is if people with complex disabilities were not getting the care packages that they need to enable them to lead the best life possible in those circumstances.”He added: “The consequences of the funding squeeze that we now face are potentially disastrous.”He pointed out that ILF had been funded by DWP and that it was a DWP decision to close it, with the first steps taken by the Conservative minister for disabled people Maria Miller in December 2010.Lamb said: “They need to reflect on what’s happened. They need to recognise the evidence of what is actually happening and rethink this.“Because of the general squeeze on budgets, [it appears] they are not being protected… so they need to go back to the drawing board and recognise actually that this approach of giving money to people with highly complex disabilities to enable them to choose their priorities and dictate how the money is spent is a good one and they ought to be prepared to revisit in the light of the evidence.”Asked whether the cuts to support for former ILF-users should have been predicted by coalition ministers, he said: “I am prepared to accept that, but they should act on this now that the evidence is emerging of what is happening.”He said he had an “open mind” on whether ILF should be reopened, but he said it was “intolerable” if former ILF-users were losing out because they had been “subsumed” within a larger local authority system that itself was facing extreme funding pressures.He said: “It needs to be addressed by government, either by reopening the fund, or by coming up with some other solution to ensure that people with complex disabilities get the support that they need.”He added: “The bottom line in all of this is how much as a society we are prepared to pay to support people with complex needs that go beyond medical need. That’s the very thing I have been trying to highlight this week.”Lamb said that the idea of splitting responsibility for disability between three departments – DWP, the Department of Health and DCLG – was “not particularly rational”.He said: “I am open-minded about the mechanisms you use and I think there is lots of scope for rationalising it and simplifying who is responsible within government for supporting these people.“But the bottom line is in my view as a civilised society we need to be prepared to come up with enough money to support people with complex needs properly to enable them to live a decent life.”Lamb told delegates earlier in the week that he was “starting a national conversation” about the “emerging crisis” in funding of both health and social care.And he said he was interested in the idea of a clearly-identified contribution to NHS and social care to be included on people’s pay-slips, as well as a right for local areas to raise additional funds for the NHS and social care if they chose to do so.Lamb pointed in his speech to his party’s many achievements on mental health in the coalition, including halving the number of people in mental health crisis who end up in police cells; drawing up the first national standards for mental health crisis care; initiating a service to divert people with mental ill-health, learning difficulties or autism away from prison; setting a “zero suicide ambition” for the NHS; and trebling the number of people accessing psychological therapies.He told delegates: “Our mission must be very simple: equality. Nothing more, nothing less. We must end the historic injustice suffered by those with mental ill-health.”last_img read more

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Disabled and older people have compared a council

first_imgDisabled and older people have compared a council’s plans to cut £5 million from its adult social care budget to “social cleansing” and have accused it of “treating people no better than animals in Longleat”.The comments were included in The Voice of those Affected, a report by Healthwatch Merton into proposed cuts by Merton council in south-west London.The report was commissioned by the council after heavy lobbying by campaigners, and was based on comments by 72 service-users and carers during a series of focus groups.The report was released as more than 20 campaigners – many of them disabled people – protested outside the council’s offices before a committee meeting this week at which councillors discussed the proposed cuts.The protesters had heard that members of the council’s ruling Labour group had already voted in secret – although not unanimously – not to increase council tax for 2016-17, or to take advantage of new powers allowing councils to increase council tax by two per cent a year to boost adult social care spending.Six speakers, including Lyla Adwan-Kamara, chief executive of Merton Centre for Independent Living (MCIL), and two disabled people affected by the proposals, spoke to the council’s healthier communities and older people’s scrutiny panel about the report and the likely impact of the cuts.Adwan-Kamara said afterwards that those speeches “brought to life what was in that report, what had been happening to them and even worse what was going to happen to them”.Following those and other presentations and discussions, the panel rejected three proposed cuts – to care and support packages, to staffing, and to scrapping a respite service – and agreed to send them back to the council’s cabinet for “review and reconsideration”.People who took part in the Healthwatch Merton focus groups said the cuts would damage their health, sever social connections, and affect every aspect of their lives, leaving some believing that life was no longer worth living.Words and phrases used to describe the cuts included “disgusting”, “devastating”, “wickedness” and “survival of the fittest”.One told a focus group: “It is like social cleansing, they are trying to get rid of the people they don’t need.”One man in his 80s said – apparently quite seriously – that he would now have to “start practising to eat less from now on”, while another contributor said: “I will end up in my flat like a hermit, self-harming again.”Another said: “I was placed in a care home. It feels like a prison. I pay £600 per week to live somewhere I hate and I don’t use any of the services.”One focus group member said the council had become “less and less supportive”, and accused it of “withdrawing help and taking things back to Victorian times”, while another said: “I had to beg social services to take notice of me. What chance is there going to be for people that don’t have a voice like I did?”The report calls for the council to commission a more detailed, independent evaluation of the impact of the cuts on disabled and older people, and concludes: “One of the key feelings voiced was a sense of betrayal and abandonment by Merton Council.“People talked of being left behind, being left on the scrapheap, and not being treated equally.”The report says there were people crying in nearly every one of the focus groups, and it warns that if the cuts go ahead, people will “potentially be making heat or eat type decisions as they may need to pay for their own care, or pay more for services that they need”.After the scrutiny panel meeting, Adwan-Kamara told Disability News Service that it was the first time the council had “really listened to our members”, but that the £5 million in cuts was “still hanging over people’s heads”.She said of the Healthwatch Merton report: “I had a fairly clear view of what people would say, because we have been hearing this through our casework.“As a centre for independent living, we knew what the issues were, but to see those comments written down in black and white and made so explicit and clear was really emotional.”She said the Labour group’s decision not to increase council tax was “unconscionable”.She said: “They have that opportunity and they are refusing to take it. They have made a choice not to raise council tax, so they have made a choice not to support the most vulnerable people in Merton.”A spokeswoman for Merton’s Labour group confirmed the scrutiny panel had asked the cabinet to look again at the three proposed cuts to adult social care, and said the budget would now be considered by the cabinet on 15 February, with a final decision taken by the full council on 2 March.She said that the Labour group “intends to keep its promise to residents to freeze council tax” and would not take advantage of the two per cent increase option.Cllr Stephen Alambritis, leader of the council, said in a statement: “I promised residents a four year council tax freeze and if there’s one thing you can say about me I keep my promises.  “I’m a business-man and I believe in running a business-like council, making what we do more efficient so we can continue to deliver the services people need the most.”Cllr Mark Allison, the cabinet member for finance, added: “The government have cut council funding by more than 40 per cent but in Merton we have done our best to protect adult social care services by ensuring it gets a lower share of the cuts than other departments, and by adding a further £12 million to its budget.  “As a result we have managed to keep the amount we spend on adult social care virtually the same since 2010.”last_img read more

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Every Entrepreneur Should Listen to These 10 Podcasts

first_img Register Now » May 15, 2019 Image credit: Hoxton/Tom Merton | Getty Images Listening to these podcasts is the next best thing to having lunch with some of the world’s most successful entrepreneurs. Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. –shares VIP Contributor Opinions expressed by Entrepreneur contributors are their own. Add to Queue Podcasts Deep Patel Whether we’re commuting to work, taking a lunch break or just looking to relax before bed, podcasts have become a best friend to many of us. It’s easy to see why. In recent years there has been an explosion of quality podcasts on nearly any topic you can think of.Podcasts fit well with our busy lives. They’re portable and easy to access at a moment’s notice; all it takes is a set of earbuds and a device with internet access. They also create a feeling of connection between the listener and the host. The intimacy of audio makes us feel like we’re part of a cozy conversation — we get to listen like we’re the only ones in the room.There are tons of great podcasts out there to explore. Below are 10 of my all-time favorites. Each offers incredible insights and amazing interviews with some of the biggest names of our time.1. The Tim Ferriss ShowTim Ferriss is a self-experimenter and bestselling author, known for his book The 4-Hour Workweek. The Tim Ferriss Show tackles topics Ferris is interested in, and is sure to teach you something new. Guests have included Arnold Schwarzenegger, LeBron James and Silicon Valley journalist Kara Swisher.During his show, Ferriss interviews world-class performers from eclectic areas, including investing, chess and pro sports, and then digs deep to find the tools, tactics and tricks that listeners can use.Related: How to Quit Slacking and Start Being More Productive With Tim Ferriss2. This Week in StartupsJason Calacanis and a rotating group of guest experts bring you this weekly take on the best, worst, most outrageous and most interesting stories from the world of web companies. Calacanis gives listeners amazing insights into how angel investing works and how he builds companies.This Week in Startups offers in-depth interviews with heavy-hitters in the tech industry who offer an insider’s look at what’s happening and what trends are emerging. Whether you’re looking to start your own company, need strategies for improving your business, need help motivating your team or just want to catch up on what’s happening in Silicon Valley and beyond, your journey should begin here.3. How I Built ThisHow I Built This showcases Guy Raz’s ability to dive into the stories behind some of the world’s best-known companies. In nearly every show, Raz uses his disarming sense of “wow” to get his guests to open up.Raz is able to tap into something deep with each person he interviews, pulling out insights and getting them to open up about nitty-gritty details they wouldn’t normally share. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists, uncovering their vulnerabilities and the inner turmoil they faced along the journey to success.4. The School of Greatness with Lewis HowesThe School of Greatness is one of the top podcasts by any standard of measurement. It has run for 500-plus episodes, has more than 40 million downloads and continually manages to snag celebrity names like Tony Robbins and Maria Sharapova.Host Lewis Howes is the best-selling author of The School of Greatness and The Mask of Masculinity. He played professional Arena League football until an injury cut his career short. His show delves into what makes the greatest people great and how to apply those lessons to your life. In The School of Greatness, he aims to share inspiring stories from the most brilliant business minds, world-class athletes and influential celebrities on the planet.Related: Listen to the Latest Episode of Entrepreneur’s How Success Happens Podcast5. How to Start a StartupThis collection of video lectures is designed to be a kind of one-stop business course for people who want to start startups. How to Start a Startup offers firsthand, hard-won knowledge from Sam Altman and others at Y Combinator. These were originally given as class lectures at Stanford University, and now they’re being offered to the world at large.The course includes lectures from Sam Altman, Dustin Moskovitz, Paul Graham, Peter Thiel, Marc Andreessen and Marissa Mayer. The show covers everything: how to come up with ideas and evaluate them, how to get users and grow your base, how to do sales and marketing, how to hire, how to raise money, company culture, operations and management, business strategy and more. If you’re serious about starting a startup, invest the time in listening to this podcast.6. a16zThe eclectic topics and insightful conversations of guests and interviewers draw you into a16z. If you’re looking for a window into the world of a top venture-capital firm, you need not look any further. Andreessen Horowitz (aka “a16z”) is a Silicon Valley–based venture-capital firm that produces this prolific podcast with multiple episodes per week. The show is typically made up of interviews with startup founders, and various partners and analysts at the firm.There are great insights here, not just into how to grow a business with venture capital, but also into tech trends in general. The host and guest experts offer advice and information that will be useful to those at any level of entrepreneurship. The show discusses tech and culture trends and news, and how they will all impact us in the near future. It features industry experts, business leaders and other interesting thinkers and voices from around the world.Related: Check Out All-New Episodes of Entrepreneur’s Problem Solvers Podcast Here7. Recode Decode with Kara SwisherOne of Silicon Valley’s most prominent journalists, Kara Swisher, hosts candid interviews with tech execs, politicians, celebrities and more, focusing on their big ideas and how they’re changing our world. In Recode Decode, she brings her ruthless, no-mercy journalism style to one-on-one interviews with some of the biggest names in tech.In a world of tech journalism that tends toward softball pitches, Swisher is playing hardball. She’s intense and intimidating, and is always ready with an incisive follow-up question. Her interviewees include Tesla CEO Elon Musk, former Secretary of State Hillary Clinton and Facebook CEO Mark Zuckerberg.8. The James Altucher ShowJames Altucher interviews the world’s peak performers in every area of life. But instead of giving you the typical success story, Altucher digs deeper to find the “Choose Yourself” story. These are the moments we can all relate to, when someone rises up from personal struggle to reinvent themselves.The James Altucher Show brings you into the lives of these ultra-successful performers, including billionaires, best-selling authors, rappers, astronauts, athletes, comedians, actors and the world champions in every field. He seeks out those who forged their own paths, found financial freedom and harnessed the power to create more meaningful and fulfilling lives. Altucher himself is a successful entrepreneur, chess master, investor and writer.9. MixergyIf you’re an ambitious entrepreneur crafting your next startup, there is no better way to get a “street smarts” education than Mixergy. The show offers listeners a chance to “learn from proven entrepreneurs.”In over 1,000 interviews, Andrew Warner doesn’t back down from asking uncomfortable questions to dig deeper into the successes and failures of the most prosperous business founders and thought leaders of our time. The ideas and stories he unearths on the show are powerful and inspiring.10. Smart Passive IncomePat Flynn is a passive-income whiz. He’s earned more than $3 million in the last six years by creating authoritative and helpful websites that cover a vast array of businesses. Smart Passive Income reveals all of his online business and blogging strategies, income sources and shrewd marketing tips and tricks so you can be ahead of the curve with your online business or blog. Flynn has been supporting his family with 100 percent passive income generated online, easily earning a 6-figure salary while working only a few hours a week.His show covers everything you need to set up successful passive income, including automation, outsourcing, crowdsourcing, search engine optimization, building authority and trust, niche sites, social media, Facebook, Twitter, YouTube, podcasting, e-books, online courses and affiliate marketing. Listen in to learn about everything that works (and doesn’t work) about creating passive income to help you better understand how to crush it with your online business. Every Entrepreneur Should Listen to These 10 Podcasts Serial Entrepreneur 7 min readlast_img read more

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Study Window screens can suppress mosquito populations reduce malaria in Tanzania

first_img Source:https://www.thelancet.com/ Mar 22 2019In an article published today in Lancet Planetary Health, a team from the Ifakara Health Institute (IHI) and Liverpool School of Tropical Medicine (LSTM), provides evidence that even window screens with no insecticide suppressed mosquito populations and dramatically reduced malaria prevalence in the Tanzanian city of Dar es Salaam.The study team has also worked with local and national government partners for over a decade to develop practical affordable implementation systems for community-based application of environmentally-friendly biological insecticides that selectively kill mosquito larvae in puddles, drains, river fringes, ponds and other sundry stagnant water bodies. Dr Prosper Chaki, who co-led the study, says “We are pleased that our efforts over all these years have culminated in government-funded scale up of larviciding, first across all of Dar es Salaam, and then to all major urban centres in Tanzania. Also, our government has invested domestic treasury funding into construction of a manufacturing plant for biological control products in Kibaha, just outside the city, which is now fully operational.” However, previous external analyses of the first large-scale pilot in Dar es Salaam indicated that larviciding only reduced malaria prevalence by 21%. Furthermore, this previous analysis3 provided no explanation for the much larger reductions of malaria prevelance that occurred over the study period, which steadily declined from >28% in 2004 to <2% by 2008.The IHI and LSTM team therefore re-assessed these epidemiological data to see how much of this remarkable 97% drop in malaria prevalence could be attributed to other factors. Only the coverage of complete window screening consistently increased to levels high enough to have any meaningful impact. While only 40% of houses had complete window screening at the start of the study in 2004, coverage had more than doubled to 86% by 2008. This surprisingly rapid scale up of window screening coverage was unplanned and spontaneous, implemented by households at their own expense, using flexible plastic screening which they found easy to install. This steady rise in window-screening coverage was statistically associated with a 92% reduction of malaria prevalence amongst residents, accounting for most of the spectacular overall decline in malaria prevalence. "Good-quality housing is a crucial factor in reducing malaria transmission across the spectrum of malaria endemicity." says Dr Emmanuel Chanda at the World Health Organization Regional Office for Africa in Brazzaville, Congo. In his supporting editorial, he continues "Killeen and colleagues' findings fall within the context of research efforts to provide hard evidence for the public health value of house screening.". Interestingly, mosquito biting rates were also reduced by as much as 92%, and impact was greatest for the most efficient malaria vector species that depend heavily on human blood. "People who live with mosquitoes protect themselves by taking advantage of any products they can access and afford." says Dr Nicodem Govella, a co-author of the study who also develops new methods for measuring just how much mosquitoes prefer and depend on human blood. He continues "Here is an encouraging example from the citizens of Dar es Salaam, who spent millions of dollars of their own money to protect their houses and families, but also protected their neighbours by making life tougher for mosquitoes".Related StoriesSouthern Research team aims to discover new, safer antimalarial medicinesHuman liver cell protein aids development of malaria parasite, study findsMalaria free status for Algeria and ArgentinaIn addition to revealing the remarkable contribution of window screens to this near-collapse of malaria transmission, this re-analysis also yielded a more encouraging estimate for the impact of regular larvicide application. Larviciding halved malaria prevalence by reducing malaria vector abundance, consistent with subsequent evaluations of scale up across the remainder of the city.In addition to demonstrating that mosquito-proofed window screening may have far greater impacts upon malaria than previously thought, these observations also challenge the view that it is too expensive and impractical for widespread use in poor countries. "While Dar es Salaam is a big city, we think our observations also have important implications for rural Africa.", says Dr Gerry Killeen who led the study. "Historically, most rural African houses have been made with mud and sticks for the walls and grass thatch for the roofs. Mosquitoes readily entered through the eave gaps between the wall and roof, which were left open for ventilation because these simple house designs lacked windows. However, Africa is changing faster than ever before, and that picture is rapidly becoming outdated across much of the continent. Houses ventilated by windows and built with bricks, timber and iron sheets are increasingly common even in rural Africa. The people who live with mosquitoes and malaria invest as much as they can in better houses, which are easier to protect with readily-available netting materials". "This study shows how the relatively simple intervention of installing window screens was taken up beyond a research study setting and led to a remarkable reduction in malaria infections in the wider community. These findings demonstrate that it can take more than a decade for research to have a real impact on the communities that need it most", says Branwen Hennig, Senior Portfolio Lead at the Wellcome Trust one of the major sponsors for the study. The authors also note that ongoing housing improvements across rural Africa are closely associated with declining malaria burden and that even bigger reductions may be possible if they could be treated with insecticides.last_img read more

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Study proves that brains of pairs of animals synchronize during social situations

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 24 2019FINDINGSUCLA researchers have published a Cell study showing that the brains of pairs of animals synchronize during social situations. The synchronized activity not only arose during various types of social behavior, but also the level of synchronization actually predicted how much the animals would interact. The team also found that brain synchrony arises from different subsets of neurons that encode the behavior of the self vs. the social partner, and that the dominant animal’s behavior tends to drive synchronization more than behavior of the subordinate.BACKGROUNDConsiderable research has been devoted to studying brain activity in individual animals behaving alone. Much of animals’ lives are spent interacting with one another — socializing, competing and so forth — and these social behaviors are generally quite complex, as an animal must not only react to other individuals, but actively predict their future behavior. Less is understood about how brain activity might function across interacting animals. Using sophisticated recording devices, the research team set out to simultaneously monitor activity in the brains of two interacting mice, making this the first study to use the technique in two animals behaving naturally together.Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingNew therapy shows promise in preventing brain damage after traumatic brain injuryNeural pathways explain the relationship between imagination and willingness to helpMETHODThe researchers attached tiny, high-tech microscopes to the heads of each mouse, which recorded activity in hundreds of individual brain cells. Fitted with the devices, the mice were placed together in pairs, first in open arenas to freely interact, and later in plastic tubes — a common method of observing competition and social hierarchy, as the dominant mouse tends to claim more of the tube’s “territory” by pushing against the subordinate mouse, or pushing it out of the tube completely.When the mice interacted with each other, their brain activity was correlated, or synced up. The more engaged they were with one another, the more coupled were their brains. This brain synchronization arose from individual cells — interestingly, some cells responded preferentially to the behavior of the self, while other cells responded only to the behavior of the social partner. The dominant mouse’s behavior tended to have more of an effect on synchronization than that of the subordinate mouse, likely because both animals in a pair are paying attention to the dominant animal.IMPACTThis is the first time that interbrain synchrony has been observed in socializing mice. Researchers believe that the insights gained from this study may shed new light on how brain activity synchronizes across humans during social interaction. Beyond adding clarity to fundamental properties of brain function in social interaction, the findings may also enable researchers to understand more about certain psychiatric and developmental disorders, including autism spectrum disorder, since many of these conditions include symptoms such as social deficits. Source:University of California – Los Angeles Health SciencesJournal reference:Kingsbury, L. et al. (2019) Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals. Cell. doi.org/10.1016/j.cell.2019.05.022last_img read more

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The Last Lunar Eclipse of 2019 Occurs Tuesday Just in Time for

first_img This Video of a 1900 Total Solar Eclipse Is the Oldest One Ever (and Made by a Magician!) How Yesterday’s Total Solar Eclipse Looked From a Plane (Photos, Video) Tomorrow (July 16), the 50th anniversary of the launch of Apollo 11 to land astronauts on the moon and two weeks after the moon totally eclipsed the sun, it will be the moon’s turn to undergo an eclipse of its own. The full moon, in Sagittarius, will pass partway through the southern part of the Earth’s shadow resulting in a partial lunar eclipse. This event favors the Eastern Hemisphere, known colloquially as the “Old World”: Africa, Europe and western Asia. Most of South America will see the moon rise already within the Earth’s shadow. Conversely, for central and eastern Asia and Australia, the eclipse will still be in progress when the moon sets during the dawn hours of July 17. Unfortunately, North America will be completely shut out; the eclipse occurs during the daytime with the moon below the horizon.These Sharks Were Too Busy to Notice a Bigger Predator Watching ThemThe unexpected twist at the end of this feeding frenzy delighted scientists.Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Headbutting Tiny Worms Are Really, Really Loud00:35关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65941-lunar-eclipse-july-2019-explained.html?jwsource=cl已复制直播00:0002:2802:28  Related: Amazing Photos of the Super Blood Wolf Moon of 2019! This NASA chart shows both the map of visibility and times of major events (in UT) of the partial lunar eclipse of July 16, 2019. Credit: NASA/Fred Espenak The penumbral phases of the eclipse occur when the moon is only within the penumbra, or the pale outer fringe of Earth’s shadow. The weak, pale-gray penumbral shading is detectable only within about 25 minutes of the partial eclipse’s beginning or end, depending on sky conditions and how carefully you look. A faint shading or smudge on the moon’s disk should become evident for most viewers around 19:35 UTC, and the last vestige of any faint tarnishing should disappear around 23:25 UTC. This will be the moon’s last interaction with Earth’s umbra for a while. During the next four lunar eclipses — all during the year 2020 — the moon will pass only through Earth’s penumbra. We’ll have to wait until the morning of May 26, 2021, when the central and western United States will be treated to a total lunar eclipse, although totality will be relatively short, lasting less than 18 minutes. Then, on the morning of Nov. 19, 2021, North Americans will be treated to an eclipse covering 98% of the moon’s diameter. Finally, on the night of May 15-16, 2022, an unusually long total lunar eclipse will be visible over most of the Americas. Totality will last almost 1.5 hours. Mark your calendars. Watch a Meteor Smack the Blood Moon in This Lunar Eclipse Video! This map shows the region of visibility for the partial lunar eclipse of July 16, 2019. Observers in South America, Europe, Africa, Asia and Australia will be able to see the eclipse, weather permitting. Credit: NASA/Fred Espenak Joe Rao serves as an instructor and guest lecturer at New York’s Hayden Planetarium. He writes about astronomy for Natural History magazine, the Farmers’ Almanac and other publications, and he is also an on-camera meteorologist for Verizon FiOS1 News in New York’s lower Hudson Valley. Follow us on Twitter @Spacedotcom and on Facebook. by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoAncestryThe Story Behind Your Last Name Will Surprise YouAncestryUndoClassmatesSearch For Any High School Yearbook, It’s Free.ClassmatesUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD SupplementsTop Cardiologist: This One Thing Will Properly Flush Out Your BowelsGundry MD SupplementsUndo In Coordinated Universal Time (UTC), the moon will enter penumbra (the weaker part of Earth’s shadow) at 18:43 and umbra (the darker part of Earth’s shadow) at 20:01. The midpoint of the eclipse will come at 21:30. The moon will leave umbra at 22:59 and leave penumbra at 00:17 on July 17, marking the end of the event. The magnitude of the eclipse, which refers to the maximum percent of the moon’s diameter immersed within Earth’s umbral shadow, will be 65%. This deepest stage of the eclipse will take place at 21:30 UTC, when the dark red-brown umbra will cover the northern 65% of the moon’s diameter. The moon will appear directly overhead, or very nearly so, from the Mozambique Channel.last_img read more

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IT sector generated 873 lakh jobs in last 5 years

first_imgBJP politics Published on SHARE SHARE SHARE EMAIL employmentcenter_img COMMENT COMMENTS The information technology (IT) sector created 8.73 lakh new jobs in the last five years, the Ministry of Electronics and IT (MeitY) has claimed, rebuffing the Opposition’s allegations of lack of employment opportunities under the Modi government.“The Congress is indulging in falsehoods… They have nothing to offer from their side. I am not using my own data, there are industry figures based on the latest Nasscom report. I speak on the basis of our performance, not rhetoric, on facts not falsehoods,” Ravi Shankar Prasad, IT Minister said. Prasad said the IT industry revenue grew from $106 billion in 2013-14 to $180 billion in 2018-19. He said the IT sector witnessed growth with initiatives such as Common Service Centres (CSCs), rural BPO promotions, start-ups and innovation.Employment in IT sectorUnder the Modi-led government, the current employment in the IT sector tallies to 41.40 lakh jobs directly and 1.2 crore jobs indirectly, as per the Nasscom report, Prasad said. “I am not using my data, I am giving Nasscom data,” he said, adding that “one can talk on facts but not on falsehoods, and if the Congress is so keen, can they show their record of employment generated in 10 years of UPA regime when the economy was down and India was a big centre of impropriety and corruption”He said the spurt in economic activities and infrastructure projects over the past five years created a number of jobs. In the new initiatives such as CSCs there have been job opportunities created for 12 lakh people and 40,000 direct and around 3 lakh indirect jobs were created through start-ups and other innovation schemes. For the rural BPOs, there are 23,000 new jobs created so far. Electronics manufacturing has added an additional 6.7 lakh jobs.“If the economy is growing at 7.4 per cent plus, if national highways are being constructed, if manufacturing is picking up, and if India’s economy is globally being recognised, it is creating more jobs,” Prasad said. About new jobs in the government departments, Prasad said that will have a ‘certain limitations’ because of various factors. About monitoring of social media platforms during elections, he said the Election Commission is already monitoring it and will lay the ground rule for working of social media during elections. March 21, 2019last_img read more

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Uikey Harichandan appointed governors of Chhattisgarh and Andhra

first_imgNEW DELHI: BJP leaders Anusuiya Uikey and Biswa Bhusan Harichandan on Tuesday were appointed as governors of Chhattisgarh and Andhra Pradesh respectively. A communique was issued by Rashtrapati Bhavan after President Ram Nath Kovind cleared their files for the gubernatorial post. Harichandan, who is a BJP leader from Odisha, replaces E S L Narasimhan, who was the governor of Andhra Pradesh for the last one decade. Uikey is a BJP leader from Madhya Pradesh. The post of Chhattisgarh governor was under the additional charge of Madhya Pradesh governor Anandiben Patel. Download The Times of India News App for Latest India News.XStart your day smart with stories curated specially for youlast_img read more

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