Tag: 上海后花园论坛

Embryonic Stem Cells Left in iPS Dust

first_img Have embryonic stem cells made any headway toward cures?  It’s sometimes hard to tell in news reports.  Science Daily ran a story from Monash University about research on how stem cells in the embryo differentiate into muscle tissue, for the purpose of helping the elderly who suffer from age-related muscle wasting conditions, but did not indicate whether human embryos were involved in the research.  It appears they studied chicken embryos to watch what happens as the stem cells develop into muscle, not for the purpose of injecting embryonic stem cells for treatment.     A paper in Nature about embryonic stem cell research appears limited to understanding transcription in normal animals,3 without any mention of potential applications for human health.  Similarly, an article on Science Daily discussed how scientists at the University of Pennsylvania are trying to understand how embryonic stem cells differentiate in living organisms.  While the press release stated that “Investigators want to make embryonic stem cells for liver or pancreatic beta cells for therapies and research,” there was no indication that the team has come anywhere close to that goal.  “By better understanding how a cell is normally programmed we will eventually be able to properly reprogram other cells,” one of them said.  Once again, embryonic stem cell therapy looks like a pipe dream.     Is there a “state of the stem cell” address?  An overview of stem cell research was provided by Erika Check Hayden in Nature,4 who said, “The field of induced pluripotent stem cells has grown up fast.  Now it is entering the difficult stage.”  She focused on the promise of iPS cells which are changing the face of biology.  “Like human embryonic stem cells, iPS cells could potentially be used as therapies, disease models or in drug screening,” she wrote.  “And iPS cells have clear advantages: they can be made from adult cells, avoiding the contentious need for a human embryo, and they can be derived from people with diseases to create models or even therapies based on a person’s genetic make-up.”     From there, Hayden described some of the “growing pains” of iPS stem cell research, but never mentioned any case in which embryonic stem cells are clearly superior to the ethics-friendly iPS cells.  The ease of reprogramming adult cells into pluripotent stem cells has led to a gold rush of research into promising therapies.  In spite of the fact that (as often happens in biology), “things are not as simple as we thought,” it was noteworthy that the thrust of Hayden’s article was about the strong momentum in the iPS research community.  The silent subtext is that embryonic research has apparently lost a lot of steam.  A few years ago, scientists were clamoring for access to human embryos for stem cell research.  Now, the discovery of induced pluripotent stem cells (iPS) from human skin and other adult tissues has sidetracked interest in embryonic stem cells.  The momentum is clearly going with iPS.  Is there any longer a need for embryonic stem cell research? 1.  Chen, Lu, Cheng, Peng, and Wang, “Isolation and Characterization of Porcine Amniotic Fluid-Derived Multipotent Stem Cells,” PLoS One 6(5): e19964. doi:10.1371/journal.pone.0019964. 2.  Panopoulos, Ruiz et al, “Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells,” PLoS One 6(5): e19743. doi:10.1371/journal.pone.0019743. 3.  Pastor, Pape, Huang et al, “Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells,” Nature, published online 08 May 2011, doi:10.1038/nature10102. 4.  Erika Check Hayden, Stem cells: The growing pains of pluripotency,” Nature published online 18 May 2011; Nature 473, 272-274 (2011); doi:10.1038/473272a. It has been very encouraging for people who value ethics to see adult stem cell research take off, leaving embryonic stem cell research in its rear-view mirror.  But what if it had turned out the other way?  What if embryonic stem cells were actively producing cures?  Experimenting on human embryos would still be unethical.  A basic principle of ethics is that ends do not justify the means (see commentary from the 09/03/2010 entry).  The past decade of stem-cell research has shown that some scientists’ greed for fame and money outruns their interest in ethics.  It takes a concerned public to keep science in check, because scientists are only human, prone to the same moral lapses as the rest of us.(Visited 19 times, 1 visits today)FacebookTwitterPinterestSave分享0center_img Skirting controversy:  “Stem cell research courts both controversy and support in the community- depending on your viewpoint,” began an article on Medical Xpress.  “Now, for the first time, scientists at Monash University’s Immunology and Stem Cell Laboratories (MISCL) have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.”  A side-by-side comparison showed the kidney cells were just as good as embryonic stem cells in producing various tissues. Chemotherapy-resistant bone marrow:  Another article on Medical Xpress reported work at the Fred Hutchinson Cancer Research Center that stem cells from bone marrow can be genetically modified to resist damage from chemotherapy, helping cancer patients endure the treatment without harmful effects.     Previously, chemotherapy treatments for gliablastoma, a brain cancer, have taken a harsh toll on patients’ bone marrow.  “Our initial results are encouraging because our first patient is still alive and without evidence of disease progression almost two years after diagnosis,” a doctor said. Parkinson’s disease:  Researchers from South Korea and Harvard have identified a “protein-based” human iPS cell” that appears promising for reversing nerve cell loss in patients with Parkinson’s Disease.  Their experiments “reversed disease when transplanted into the brain of rats modeling Parkinson disease.”  Though the article mentioned embryonic stem cells as one of the two sources of stem cells, it did not produce any evidence that embryonic stem cells are effective – only the iPS cells. Vision forum:  Eye diseases such as “age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and other retinal diseases” affect millions worldwide, an article on Medical Xpress said.  Can iPS stem cells from human skin treat these devastating conditions?  Apparently so; “Scientists from Schepens Eye Research Institute are the first to regenerate large areas of damaged retinas and improve visual function using iPS cells (induced pluripotent stem cells) derived from skin,” they said.  A paragraph in the article shows that many vision researchers would prefer to avoid ethical controversies with embryonic stem cells: While Tucker, Young and other scientists were beginning to tap the potential of embryonic and adult stem cells early in the decade, the discovery that skin cells could be transformed into “pluripotent” cells, nearly identical to embryonic cells, stirred excitement in the vision research community.  Since 2006 when researchers in Japan first used a set of four “transcription factors” to signal skin cells to become iPSCs, vision scientists have been exploring ways to use this new technology.  Like embryonic stem cells, iPSCs have the ability to become any other cell in the body, but are not fraught with the ethical, emotional and political issues associated with the use of tissue from human embryos. So far the tests are being done on mice.  “The two scientists say their next step will be to take this technology into large animal models of retinal degenerative disease and eventually toward human clinical trials.” Amniotic fluid health potion:  In a paper on PLoS One,1 Chinese researchers announced success deriving multipotent stem cells from amniotic fluid of pigs.  They were able to get these stem cells to differentiate into nerve, fat, and heart tissues without producing teratomas (tumors).  They said, “These optimal features of pAF-MSCs provide an excellent alternative stem cell resource for potential cell therapy in regenerative medicine and transgenic animals.”.  Even in China these researchers were aware of the controversy.  They said, “human amniotic fluid may be a new source of pluripotent stem cells without any ethical concerns associated with human embryonic stem cells (hES cells) research.” Umbilical vein health potion:  Another paper in PLoS One by the Salk Institute showed success at getting induced pluripotent stem cells from human umbilical vein endothelial cells.2  Their process was “rapid and highly efficient,” they reported, and produced stem cells that were “indistinguishable from human embryonic stem (ES) cells with regards to morphology, pluripotent marker expression, and their ability to generate all embryonic germ layers in vitro and in vivo.” Progeria find-and-replace:  An exciting discovery at Salk Institute shows the potential of adult stem cells to do “find and replace” operations on diseased genes, such as those with progeria, a degenerative disease that causes premature aging.  PhysOrg explained the process: The gene-targeting approach developed by Suzuki and his colleagues relies on the use of so-called helper-dependent adenoviral vector to deliver large mutation-free DNA molecules into cells.  Once there, these replacement pieces initiate a process known as homologous recombination, which works a bit like the “find-and-replace” command in a word processor.  If a piece of DNA is long enough, it will find and line up with the same sequence in the genome and swap places.     “The process was remarkably efficient and we couldn’t detect any undesired off-target effects such genomic instability or epigenetic abnormalities,” says Liu.  “What’s more, it allowed us to show that we can correct multiple mutations spanning large genomic regions.” The team used adult mesenchymal stem cells and iPS cells from progeria patients to test the genetic editing procedure.  The article said that these cells have been shown to differentiate into a wide variety of tissues, including “adipocytes, osteoblasts, chondrocytes, cardiomyocytes, adipocytes, and, as described lately, beta-pancreatic islets cells.” Regeneration takes a village of cells:  Don’t expect to grow a new arm with stem cells.  In an article on Science Daily, researchers at the Washington University School of Medicine in St. Louis found that, at least for zebrafish, multiple cell types are needed to regrow a lost fin. Crop yields:  Plants have stem cells, too – and not just in their stems.  Researchers at Texas Agrilife Research are studying stem cells in Arabidopsis to learn how to make plants produce more fruit, seeds and leaves, according to PhysOrg.last_img read more

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‘I can make history again’: Novak eyeing second ‘Djoko Slam’

first_img“I know it’s two weeks potentially long, and I just need to be in my lockdown mentally, and just do things that have worked for me in the past.”Twelve months ago, Djokovic dropped out of the world’s top 20 after a shock quarter-final loss to Marco Cecchinato at Roland Garros and even pondered skipping Wimbledon, but he has instead reclaimed his place at the top of the game.He won his second Wimbledon last July and followed it up with back-to-back triumphs at the 2018 US Open and the Australian Open earlier this year.“It’s quite (a) different situation for me now than it was 12 months ago, obviously. Very different,” the 32-year-old added.A single break in the opening game of the match proved enough for Djokovic to take the first set, and the Serb raced through the second in under half an hour.ADVERTISEMENT The Serbian is one of only three men, along with Don Budge and Rod Laver, to have won four straight Slam tournaments, after his first, and so far only, French Open title in 2016.Now he can follow in Australian great Laver’s footsteps by achieving the feat twice with victory in the final in Paris on June 9.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logistics“I put myself in a situation where I can actually make history of tennis again and obviously I have very high ambitions for this tournament,” said Djokovic.“It’s not a secret. But at the same time, it’s not the first time that I’m facing these kinds of circumstances. It’s not the first Grand Slam in my career. I have played so many. PDEA chief backs Robredo in revealing ‘discoveries’ on drug war The 22-year-old Hurkacz, who has claimed three wins over top-10 players this season, had no answer as Djokovic sealed a second-round spot after another dominant set on his first match point.“I’m focused, I’m determined, and sharp from the blocks. That’s what happened,” he said.“Even though I never played him (before), never faced him in (an) official match, I still felt he can be a great threat if I allow him to play his tennis.”Next up for Djokovic is Swiss world number 104 Henri Laaksonen for a place in the last 32.“I don’t know too much about him, to be honest. I never played against him, and I did watch him play maybe once or twice.“I’m going to have to do my homework and see what happens.”Sports Related Videospowered by AdSparcRead Next Serbia’s Novak Djokovic flashes a thumbs up as he celebrates winning his first round match of the French Open tennis tournament in three sets 6-4, 6-2, 6-2, against Poland’s Hubert Hurkacz at the Roland Garros stadium in Paris, Monday, May 27, 2019. (AP Photo/Pavel Golovkin)World number one Novak Djokovic said that he “can make history again” as he looks to hold all four Grand Slam titles simultaneously for the second time, after easing into round two at the French Open on Monday.Djokovic laid down an early marker at Roland Garros, powering past promising Polish youngster Hubert Hurkacz 6-4, 6-2, 6-2 in his opening match.ADVERTISEMENT Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue Klay Thompson adds meditation to his mental preparation DA eyes importing ‘galunggong’ anew Trending Articles PLAY LIST 00:50Trending Articles02:44Djokovic wins Laureus Sportsman of Year Award00:50Trending Articles02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Catholic schools seek legislated pay hike, toocenter_img Cayetano: Senate, Drilon to be blamed for SEA Games mess LATEST STORIES Two-day strike in Bicol fails to cripple transport ‘Rebel attack’ no cause for concern-PNP, AFP Don’t miss out on the latest news and information. Private companies step in to help SEA Games hosting MOST READ View commentslast_img read more

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Captain Upul Tharanga calls for patience before India ODIs: Can Sri Lanka turn it around?

first_imgA day after Sri Lanka’s test captain Dinesh Chandimal apologised for a 3-0 series whitewash against India, limited-overs captain Upul Tharanga has asked fans for patience ahead of their upcoming ODIs and Twenty20 matches.Sri Lanka failed to challenge the world’s top-ranked Test side during the three-match series and the gulf in quality between the two sides was clearly visible.They also suffered their maiden one-day international series loss to Zimbabwe last month, prompting long-serving captain Angelo Mathews to step down.Sri Lanka next play five ODIs and a Twenty20 against the Virat Kohli-led India, starting on Sunday, which will be Tharanga’s first as full-time captain.”Every team goes through a rough patch,” Tharanga said in a statement from Sri Lanka Cricket. “This is something that happens in cycles to every team and every nation no matter how great a cricketing nation they are.”Sri Lanka dominated in all three formats for a good 18 years – don’t forget this now when we are going through a rough patch.”The 32-year-old said the 1996 World Cup winners had already identified areas for improvement.”These areas are being taken care of, and we are seeing the results behind the scenes – however it will take a little more time for it to be seen externally, so please have patience, and most importantly have faith,” Tharanga said.Sri Lanka have recalled all-rounders Thisara Perera and Milinda Siriwardana to their limited-overs squad and Tharanga was confident of defeating India.”Sri Lanka have always been stronger in our white-ball format, and I am confident that we will come out strong and beat India,” he said.advertisement”We have the talent, we have the skill. We have been putting in the hard work, we just need the spirit, and for that we need your support too.”Squad:Upul Tharanga (captain), Angelo Mathews, Niroshan Dickwella (wicketkeeper), Dhanushka Gunathilaka, Kusal Mendis, Chamara Kapugedera, Milinda Siriwardana, Malinda Pushpakumara, Akila Dananjaya, Lakshan Sandakan, Thisara Perera, Wanindu Hasaranga, Lasith Malinga, Dushmantha Chameera, Vishwa Fernando.last_img read more

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30 Years of National Competition – part four

first_imgIn this edition, we look back at the National Championships held between 1994 through to the beginning of the National Touch League in 1997, as well as the All Stars of Touch teams selected from the events. New South Wales clinched the Men’s Open title at the 1994 National Championships in Southport 3-2 following a controversial extra-time touchdown. The Gold Coast Bulletin had the following to say about the game:“The extra time period was less than a minute old when Wayne Bambury scored a touchdown despite calls from the Queensland camp that he had been touched before they forced the ball down.”“Ironically, Queensland also lost to New South Wales in drop-off situations in the Women’s Open and the Mixed Open finals.”New South Wales defeated Queensland in the Women’s Open 3-2, while they won the Mixed Open 4-3. New South Wales were also victorious in the Women’s 30’s division, winning 4-2, while Queensland won their only title in the Men’s 35’s division by one touchdown, 3-2. The 1994 National Championships also hosted four non-national events, with the Men’s 40’s, Men’s 45’s, Men’s 20’s and Women’s 20’s divisions being added to the line up. New South Wales defeated Queensland by one touchdown in the Men’s 40’s division, and also got a win in the Men’s 45’s division, 5-2. Queensland also got two wins in the non-national events, winning the Men’s 20’s 6-0, as well as the Women’s 20’s division by one touchdown, both against New South Wales. Queensland hit back at home in 1995, walking away with the Champion State National Title, defeating arch rivals New South Wales. The 14th National Championships were played at Owen Park, Southport in October 1995, and the home side did their state proud. Like in recent years, there was almost nothing separating Queensland and New South Wales, with both the Men’s and Women’s finals being decided by a drop off. In the Women’s division, Queensland led 3-2 with minutes remaining before New South Wales’ Captain Katrina Maher scored a touchdown to level the game and send it into extra time. New South Wales’ Jody English scored after nine minutes to take the lead for the first time in the game and the National Championships title. In the Men’s division, the game went to a drop off between New South Wales and Queensland following a close encounter for the 40 minute duration. Both teams scored one touchdown in the first half, while neither managed to score in the second half, sending the game into extra time. Queensland’s Bob Brindell scored the winning touchdown to end New South Wales’ three year reign of the title. In the Mixed Open division, New South Wales proved too strong for Queensland, winning 4-1, while they also took out the Women’s 30’s and Men’s 20’s division by one touchdown. Queensland also won the Men’s 30’s and 40’s divisions as well as the Women’s 20’s division to take out the Champion State title. In 1996, the National Championships was not played for the Open divisions, while the Senior divisions were still contested. There were several changes, with the New South Wales and Queensland’s Open sides competing in the first State of Origin, while the emerging states and territories were given a tournament of their own. The Southern Cross National Open Championships were held in Torrensville, South Australia and played host to teams from Victoria, the Australian Capital Territory, Tasmania, South Australia, Western Australia and the Defence Force. In the National Championships, New South Wales and Queensland were quite evenly matched. New South Wales won the Men’s 30’s, Women’s 35’s and Men’s 45’s divisions, while Queensland won the Mixed Juniors and Men’s 35’s. The two states also drew in the Women’s 30’s and Men’s 40’s divisions. The National Touch League was implemented in 1997 to replace the old National Championships. Instead of concentrating Australia’s representative talent into two powerhouse teams, it was decided to divide the 240,000 strong Australian Market into 12 competitive sides. It was hoped at the time that this process would also establish a strong national club structure.  The tournament finals were broadcast on WIN, NBN and Optusvision, while NBN the host broadcaster also ran 50 television commercials to promote the event. In the Men’s Open division, the Sydney Scorpions and the Brisbane Cobras met in the final, and after trailing 3-1, the Cobras hit back to level the game at 3-all at full time. The deadlock was broken when Scorpions player Shane Fredrickson scored to win the first NTL title. He was also named Player of the Final, while Gavin McDonald was named Player of the Series. In the Women’s Open final, the Sydney Mets dominated the first half of the game against the Cobras, and were unlucky not to go to the half time break with more than a 1-0 lead. The Cobras hit back in the second half however, and scored two quick touchdowns to take out a 2-1 victory. The Cobras’ Catherine Barr was given the Player of the Final accolade while the Gold Coast’s Sharyn Williams was voted Player of the Series. The Mixed Open final saw the Sydney Rebels tough it out against the Brisbane Cobras. The game was deadlocked at 5-all before the Rebel’s Darren Shelley scored two quick touchdowns to take the inaugural title 7-5. Shelley was rewarded for his dominant performance, being named Player of the Final, while the Cobras’ Dione Williams was named as the Player of the Series. The National Touch League continues to this day, and the 2010 X-Blades NTL will see a record 146 teams compete across 14 divisions in Caloundra. Stay tuned to the Touch Football Australia and National Touch League websites for all the latest information regarding the 2010 X-Blades National Touch League. 1994 All-Stars of Touch Leesa Johnston (QLD), Steve Hughes (ACT), Ron Chilby (NSW), Mark Scott (NSW), Darren Shelley (NSW), Michael McGovern (ACT), Lynette Hardy (NSW), Swain Rovelli (QLD), Steve Golding (NSW), Trevor McPhillips (QLD), Ray Wilson (NSW), Wayne Clifford (NSW), Gai Taylor (NSW), Donna Hollingsworth (NSW). Coach of the Year: Greg Newman (NSW), Manager of the Year: Kathie O’Brien (QLD), Referee of the Year: Niki Ward (QLD), Official of the Year: Dick Fairbairn (NSW – ATA Life Member).1995 All Stars of Touch Robert Brindell (QLD), Kevin Feldman (QLD), Tony Howard (NSW), Leesa Johnston (QLD), Katrina Maher (NSW), Mark Scott (NSW), Stacey Gregory (NSW), Steve Tomlin (TAS), Scott Lewis (NT), Louise Mumford (WA), Tanya Mitchell (WA), Kelly Pickering (SA), Trent McDonald (QLD), Natalie Wilkinson (QLD).Coach of the Year: Keith Harris-Walker (WA), Manager of the Year: Ken Crawford (NSW), Referee of the Year: Rick Borg (QLD), Official of the Year: Ian Stanley (NSW – TIP Director).1996 All Stars of Touch Margie Allen (QLD), Scott Notley (QLD), Judy Malcolm (NSW), Gary Simons (NSW), Rob Pratt (QLD), Kieran Gavin (NSW), Maurice Stewart (NSW), Kerry Norman (QLD), Donna O’Connor (NSW), Craig Madders (QLD), Giselle Tirado (NSW), Jody English (NSW), Neil Ward (QLD), Robert Brindell (QLD). Coach of the Year: Colin Jenkinson (QLD), Manager of the Year: Karama Doreset (WA), Referee of the Year: Gary Mournehis (NSW), Official of the Year: Dr Paul Webb (ATA – Life Member).Touch Football Australia is calling on the Touch Community far and wide to celebrate 30 years of National Championships. Have you booked your tickets to the 30 Year Celebration Breakfast to be held on Sunday, 14 March, the day after the 2010 X-Blades National Touch League? Call Touch Football Australia on (02) 6212 2800 to book your seat.last_img read more

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10 months agoMan Utd fullback Shaw on Solskjaer: My first impressions

first_imgAbout the authorPaul VegasShare the loveHave your say Man Utd fullback Shaw on Solskjaer: My first impressionsby Paul Vegas10 months agoSend to a friendShare the loveManchester United fullback Luke Shaw admits he’s enjoying the work of new manager Ole Gunnar Solskjaer.Shaw says the Norwegian has managed to turn around mood at the club in a short amount of time and believes United fans are appreciating his positive approach to the role.”I think you can see from the outside how much he has changed things in such a short space of time,” he said.”He is just a really positive manager, he knows what the club needs and also what the fans want in the way we are playing.”He’s bringing that attacking, quick play back to Old Trafford. I’m sure the fans are going to appreciate that as much as we [the players] do.” last_img read more

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10 months agoSevilla need Man Utd co-operation to get Bailly deal done

first_imgSevilla need Man Utd co-operation to get Bailly deal doneby Paul Vegas10 months agoSend to a friendShare the loveSevilla need Manchester United’s co-operation to get a deal done for Eric Bailly.Estadio Deportivo says Sevilla coach Pablo Machin is ‘seriously interested’ in bringing the Ivorian back to La Liga.A loan deal until the end of the season may be a possibility as Los Rojiblancos look to bolster their defensive options going into the second half of the season.There are concerns though that Bailly’s wage demands could prove to be a stumbling block with his weekly pay said to be around £75,000.Sevilla would require United to pay some of his salary if a loan move is to materialise. TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

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Eastern refineries could save millions by buying more Canadian oil CERI report

first_imgCALGARY – Refineries in central and Atlantic Canada could save money on oil costs and produce fewer global greenhouse gas emissions if they bought more Canadian crude oil, according to a study by the Canadian Energy Research Institute released Wednesday.The study finds that substituting Canadian oil wherever possible using space on existing pipelines, railcars and ocean tankers would result in a 47 per cent reduction in foreign oil imports into Eastern Canada, saving the refineries $210 million per year and the equivalent of more than two million tonnes of carbon dioxide, or about 5.7 per cent.It adds that expanding the transportation system through a new pipeline equal to TransCanada Corp.’s cancelled Energy East would allow the eight refineries in Ontario, Quebec, New Brunswick and Newfoundland and Labrador to replace 57 per cent of imported oil at a savings of $317 million per year, while still cutting GHGs by two million tonnes.“I think there’s an opportunity for the energy sector to do more work together — east to west — to benefit Canada as a whole,” said CERI CEO Allan Fogwill following a presentation in Calgary.“There’s a social benefit in keeping it in the family and an economic benefit for eastern refineries (along with) an environmental benefit internationally.”He said the report, based on 2016 numbers gathered mainly without the refiners’ co-operation, doesn’t answer the question of why they buy from foreign suppliers when it would make sense to buy from within Canada.But he said he hopes its conclusions lead to a discussion about where the refineries source their oil.Peter Boag, CEO of the Canadian Fuels Association, which represents refiners, said operators weigh many factors to maximize the economic efficiency of their refineries, including looking at the composition of different types of crude oil.“Crude cost, the configuration and complexity of the refinery, and anticipated product demand are all factors that influence crude oil choice,” he said.He added that providing eastern Canadian refineries with better pipeline access to western Canadian crude would provide further flexibility in crude selection.The CERI study notes that the eastern refineries process just over one million barrels per day, of which 56 per cent comes from foreign countries led by the United States at 260,000 barrels of oil per day.About 39 per cent comes from Western Canada and five per cent is from eastern Canadian sources such as the offshore oilfields of Newfoundland and Labrador.Follow @HealingSlowly on Twitter.Companies in this story: (TSX:TRP)last_img read more

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The Latest Ukraine says ships were in international waters

first_imgMOSCOW — The Latest on raised tensions between Russia and Ukraine (all times local):12:30 p.m.Ukraine has released what it says is the exact location near Crimea where its vessels were fired on and seized by Russia over the weekend, showing that they were in international waters.The statement by Ukrainian officials contradicts Russia’s argument that it was chasing the ships because they were violating its territorial waters. Russia considers Crimea, which it annexed in 2014, part of its country.The Ukrainian ministry in charge of occupied territories on Wednesday published what it claimed were the exact co-ordinates of where the military vessels “Berdiansk”, “Nikopol”, and “Yany Kapu” were when they were attacked by Russia, putting them outside the 12-mile zone of territorial waters.Russian border guards have captured the vessels and the crews. Officials say they will try the seamen for violating the Russian border and that they do not consider them prisoners of war.___10:20 a.m.A military official says Russia will boost the defence of the occupied Crimean peninsula with more anti-aircraft missiles.The Interfax news agency on Wednesday quoted Col. Vadim Astafyev, the top Defence Ministry official in Russia’s south, as saying that Russia will add one S-400 anti-aircraft missile system to the three already deployed in the peninsula.The announcement comes three days after Russian border guards fired on three Ukrainian vessels and seized them and their crews. The first overt military confrontation between the two neighbouring countries has raised the spectre of a major conflict.Ukraine said its vessels were operating in line with international maritime rules, while Russia alleged they had failed to get permission to pass.The Associated Presslast_img read more

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POLICE ISSUES SAFETY TIPS

first_imgFacebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsApp The Royal Turks and Caicos Islands Police Force (RTCIPF), has issued these safety tips soley as a precaution in the event of a Robbery at any business place in the Turks & Caicos Islands (TCI).BEFORE OR DURING INCIDENT:1. Do not be heroic.2. Stay calm.3. Obey the offender’s instructions.4. Never assume a firearm is fake or a toy.5. Use non-threatening behaviour and avoid eye contact.6. Observe the offender as much as possible.7. Stay out of danger if you are not directly involved.FOLLOWING THE INCIDENT:1. Call 911.2. Don t hang up unless told to do so. Keep the line open.3. Supply to 911:• Name and address of premises• Number of offenders and brief description• Description of vehicle if used• Direction of travel4. Check for injuries to staff and customers. Tell the 911 operator if an ambulance is required- 911 can call an ambulance.5. Keep everyone away from anything the offender may have come in contact with such as counters. Avoid moving or touching anything left behind.6. Avoid touching firearms or ammunition.7. Avoid touching spent cartridges or bullet holes.8. Request everyone to remain.9. Obtain name and contact details of all witnesses if possible.10. Have all staff and customers record their observations independently.11. Discuss the matter with Police before you speak to the media.Police are urging anyone with information about any crime to call Crime Stoppers on 1800 8477 or use the Crime Stoppers online reporting page: https://www.crimestoppers.tc. Information you provide will be treated in the strictest of confidence. We remind people they should not report crime information via our Facebook and Twitter pages.center_img Related Items:last_img read more

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Toastmasters Pay Courtesy Call on the Prime Minister

first_img Related Items: Facebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsApp#Bahamas, October 18, 2017 – Nassau – Toastmasters from various local clubs, and officers, recently paid a courtesy call on Prime Minister Dr. the Hon. Hubert Minnis at the Office of the Prime Minister (front row, centre).Pictured with the Prime Minister are: Ivan C. Thompson DTM – Division I Director, Andre Kelly DTM – Division F Director, Keith L. Major DTM – Advisor, TM Chervez Brown – Area 90 Director, TM TiaMaria Albury – Area 91 Director, TM Kendra Munroe – Area 92 Director, TM Lynette Bowley – Area 60 Director, TM Ruthlin Hanna – Area 61 Director, TM Garth Jackson – Area 62 Director, TM Nikenya Rolle – Club Growth Director, TM Dion Knowles – President, First Bahamas Branch, TM DiAndra Gibson – President, Commonwealth Bank Blue Diamonds Club, TM Kohfe Miller – President, Evangelistic Temple Club, TM Sheena Culmer – President, Bahamas Public Service Union Club, TM Deandra Dorsette – President, Bahamas Union of Teachers Club, TM Matt Knowles – President, Annunciation Greek Orthodox Church Club, TM Jana Stubbs – President, First New Providence Branch, TM Nadia Humes – Vice President Membership, Healing Communicators Club, TM Tarnisha Fowler – Vice President Membership, Bahamas Faith Ministries Club, TM Patricia Hamilton, TM Owenique Palmer, TM Gale Roberts, TM Tanya Sturrup, and TM Anissa Sweeting.(Photo/Yontalay Bowe, OPM Media Services)last_img read more

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Essar Bags 54 Million Contract from Saudi Aramco

first_imgEssar Projects, an engineering company on Tuesday announced that it has bagged a $54 million (₹328 crore) project from Saudi Arabian national oil and natural gas company Aramco.The project, which is scheduled to be completed in two-and-a-half years, will involve procurement and construction of crude tank, replacement of crude pumps, piping, electrical and instrumental facilities.”This contract is a reflection of our capability to undertake global projects from reputed clients in this region. We will leverage the capabilities gained to enhance our foot print in other Middle East countries,” Amit Gupta, CEO of Hydrocarbon SBU, Essar Projects said in a statement.The company has previously set up a world-scale grass roots refinery at Vadinar, Gujarat, with an initial capacity of 10 million tonnes per annum, which was later expanded to 14 MMTPA and then to 20 MMTPA.The company had also implemented Single Buoy Mooring (SBM) method for crude unloading, product jetty for refinery product export, a tank farm with total capacity of 3 million cubic metres for crude, and 77 MW of captive power plant.However, on Tuesday, stock price of Essar Oil Limited recorded 0.48 percent lower at ₹114.40 per share.On 3 August last year, Saudi Aramco and Sumitomo Chemical transferred ownership of 32 billion riyal ($8.5 billion) petrochemical facility to their joint group PetroRabigh, Reuters reported.Ownership of the planned new factory will be transferred from Aramco and Sumitomo to PetroRabigh in the fourth quarter of 2014, the company said on Sunday.last_img read more

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Anil Ambani Announces Rs5000 Crore New Defence Investment

first_imgWith the recent acquisition of Pipavav Defence, Reliance Group chairman Anil Ambani announced on Thursday that an additional investment of Rs.5,000 crore will be made as part of India’s emphasis on “Make in India” for military hardware and cut imports.He also underscored the need for larger public-private partnerships in the defence domain, and called for pooling of resources so that India becomes self-reliant in protecting its boundaries and cuts reduces its dependence on the global markets.Quoting extensively from the experiences he gained from his late father, the legendary industrialist Dhirubhai Ambani, the Reliance Group chairman said his father’s vision was to meet the aspirations of generations with self reliance, adding that the Make in India initiative of Prime Minister Narendra Modi is a major step towards that.”This initiative of the government redefines the defence ecosystem in India with our Navy in the lead… For a country with one of the longest coastlines in the region and vast expanse of territories over the seas, self reliance in naval capabilities is an ever challenging imperative,” he said.The Reliance Group chairman said the acquisition of the Pipavav Defence Company in Gujarat with assets worth more than Rs.10,000 crore was his company’s contribution towards self reliance.”Pipavav has the largest dry dock in the country and the second largest in the world. With more than 30 lakh sq ft of covered area for fabrication and integration alone, this is perhaps the largest single location defence manufacturing facility in India,” he said.”We will invest an additional Rs.5,000 crore over the next few years as part of our commitment towards indigenisation efforts.”He said that the Pipavav facility will be capable to deliver “all requirements of the Indian Navy from frigates to aircraft carriers to submarines”.Russia, meanwhile, has chosen Pipav as a partner to build three updated versions of Talwar-class frigates, likely to be the biggest-ever warship-building project for private sector in India worth around $3-$3.5 crore.Ambani said self reliance in defence is also needed so that India does not have to compromise on its foreign policy.”Large part of our Defence inventory have dependency on global relations. This creates limitations and sub-serves our foreign policy. Self-reliance gives us the flexibility to pursue our foreign policy objectives,” he said.He said since the sole consumer for domestic defence hardware was the government, “specific measures towards ease of doing business will encourage industry participation”. Accordingly, he suggested an advisory committee with chief executives from public and private sectors to meet regulary to “align and converge the understanding and aspirations of all stakeholders”.”There is need to institutionalise private sector participation not only for indigenisation but the entire spectrum of defence production through groups comprising Private Sector companies and PSUs at MoD to pool resources,” he said also suggesting a separate joint secretary in the defence ministry for the private sector.”Today, in the ministry of Defence we have joint secretaries responsible for different public sector undertakings. I believe there is a case for a joint secretary exclusively to engage at the business level with the private sector,” he said.Ambani also expressed hope that the updated defence procurement procedure (DPP) will help “in ease of doing business with MoD… Transparent, fair procedures and processes creates a favourable climate, encourage competitiveness and eventually deliver the best overall value for the country,” he said.Another suggestion from the industrialist was to introduce courses at IITs, IIMs and other higher learning institution related to the requirements of the defence industry.last_img read more

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State Lawmakers Houston Officials Weigh Measures To Curb School Shootings

first_img X To embed this piece of audio in your site, please use this code: 00:00 /00:37 Listen REUTERS/Jonathan Bachman/Via Texas TribunePolice tape in front of Santa Fe High School in Santa Fe, Texas on May 20, 2018.Texas lawmakers are meeting today in Austin to consider how to protect schools against gun violence. The hearing comes three weeks after the shooting at Santa Fe High School that killed 10 people and injured more than a dozen others. Efforts to curtail school shootings are also moving ahead in Houston.Mayor Sylvester Turner’s Commission Against Gun Violence is working to come up with safety measures that can be put in place before the next school year starts.Harris County Sheriff Ed Gonzalez is on the mayor’s commission. “This was already in the making for some time, so it wasn’t simply a response to Santa Fe,” Gonzalez says. “He’s concerned a lot about just everyday gun violence as well.”The commission held its first meeting at the end of May. Sheriff Gonzalez says Mayor Turner has also directed the group to come up with a second round of recommendations by year end, in time to propose them to state lawmakers before the Legislature convenes in January. Sharelast_img read more

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Know why women are better at reading mind

first_imgEver wondered how your wife or partner is able to read your thoughts and emotions just by looking at your eyes? Her ability to interpret may be the result of a gene influence, say researchers, one of Indian-origin.The findings showed that the genetic variants on chromosome 3 in women are associated with their ability to read the mind in the eyes — known as cognitive empathy.The closest genes in this tiny stretch of chromosome 3 include LRRN1 (Leucine Rich Neuronal 1) which is highly active in a part of the human brain called the striatum — which has been shown using brain scanning to play a role in cognitive empathy, the researchers said. Also Read – Add new books to your shelf”This is an important step forward for the field of social neuroscience and adds one more piece to the puzzle of what may cause variation in cognitive empathy,” said Varun Warrier, doctoral student at the University of Cambridge. Scientists have built upon a study first performed 20 years ago, called the “Reading the Mind in the Eyes” test.For the new study, published in the journal Molecular Psychiatry, the team analysed cognitive empathy in 89,000 people on this test. Also Read – Over 2 hours screen time daily will make your kids impulsiveThe results confirmed that women on average do score better on this test because of gene’s influence.In addition, the researchers found that genetic variants that contribute to higher scores in the test also increase the risk of anorexia, but not autism, the researchers noted.”We are excited by this new discovery, and are now testing if the results replicate, and exploring precisely what these genetic variants do in the brain, to give rise to individual differences in cognitive empathy,” explained Simon Baron-Cohen, Professor at the University of Cambridge.last_img read more

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Rep Hughes Muskegon County official testify on assessor legislation

first_img LANSING – Rep. Holly Hughes, R-Montague, and Muskegon County Equalization Director Donna VanderVries testified in support of House Bill 4888 before the Senate Committee on Local Government on Tuesday.HB 4888 would allow an assessor to maintain the local property assessment roll electronically, instead of on paper only“This is a fairly simple bill, which came about from working with Donna,” Rep. Hughes said. “Every year township and county assessors have to print out the assessment rolls, but if even one mistake is made then the entire roll has to be reprinted. That’s hundreds or thousands of pages and with it added costs.”“This bill addressed a critical need and will help bring storage of assessor rolls into the 21st century,” VanderVries said to the committee.Following testimony by Rep. Hughes and VanderVries, the Michigan Department of Treasury, Michigan Assessors Association and Michigan Townships Association all shared their support of HB 4888.The committee did not vote on the legislation. 02Feb Rep. Hughes, Muskegon County official testify on assessor legislation Categories: Hughes News,Newslast_img read more

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