Month: August 2019

Protein lifetime and the stability of cell structures

first_img(Phys.org) —The ability of a cell to move, replicate, and recast itself according to the needs of the organism which it serves, comes at it price. The extreme flexibility of cells takes its origin from the constant turnover of nearly every component with which they are made. There are a few exceptions to this general principle for a few protected regions like, for example, the lens of the eye, or the collagen matrix within the extracellular space. In a new paper published in Cell, researchers show that certain components of the pore complex that controls the flow of components out of the nucleus, escape the normal turnover cycle, and may persist for the lifetime of the cell. Some Nuclear pore complex proteins can last for the lifetime of the cell. Credit: learn.genetics.utah.edu More information: Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures, Cell, Volume 154, Issue 5, 971-982, 29 August 2013. DOI: 10.1016/j.cell.2013.07.037AbstractIntracellular proteins with long lifespans have recently been linked to age-dependent defects, ranging from decreased fertility to the functional decline of neurons. Why long-lived proteins exist in metabolically active cellular environments and how they are maintained over time remains poorly understood. Here, we provide a system-wide identification of proteins with exceptional lifespans in the rat brain. These proteins are inefficiently replenished despite being translated robustly throughout adulthood. Using nucleoporins as a paradigm for long-term protein persistence, we found that nuclear pore complexes (NPCs) are maintained over a cell’s life through slow but finite exchange of even its most stable subcomplexes. This maintenance is limited, however, as some nucleoporin levels decrease during aging, providing a rationale for the previously observed age-dependent deterioration of NPC function. Our identification of a long-lived proteome reveals cellular components that are at increased risk for damage accumulation, linking long-term protein persistence to the cellular aging process. The ‘weakest link’ in the aging proteome Journal information: Cell Extracellular proteins, like crystallins of the lens, or components of cartilage, accumulate damage over time that compromises their function. Clouded vision or stiff joints are the familiar result. Inside cells however, an intricate accounting system exists whereby proteins are stochastically festooned with sequential markers for degradation—much like a trainee might predictably progresses through the colored ranks of Karate. In yeast, it has been reported that the average protein half-life is just 90 minutes, while for mammals it may be more like 1 or 2 days.An exception to this rule is our DNA, which owes its long life to dedicated repair mechanisms that patch up damage. For proteins however, no such sequence-level mechanisms are known to exist. The histone proteins that bind DNA have also been observed, in some cases, to be exceptionally long-lived. Measuring these lifetimes reliably, particularly for the older generation, requires some special experimental considerations. The researchers used a method called pulse-chase labeling, which requires feeding newborn rats a diet containing exclusively the 15N isotope as the pulse. A normal 14N diet, the chase, was begun after 6 weeks, and the animals then sacrificied at various times over the ensuing year. The cellular components were then fractionated and mass spectrometry was used to comprehensively identify long-lived proteins in the brain. The lifespans of a few components of the nuclear pore complex (NPC) were particularly striking. The NPC contains multiple copies of over 30 different subvarieties of the nucleoporin (Nup) family alone. Two particular subcomplexes of Nup proteins, which serve as scaffold components, where found to resist degradation. The researchers also measured translation levels of these and 11,000 other proteins to measure synthesis levels concomitantly. Every long-lived protein was found to also be actively involved in translation.Unlike other large protein complexes, such as ribosomes or proteasomes, the NPC apparently does not turnover as an entire complex. Instead individual subcomplexes are exchanged at specific rates as new copies are synthesized. What mechanisms might administer this exchange, if any, are as yet unknown. The researchers found, in particular, that 25% of those proteins within a certain complex (Nup205), have not been replaced after a year. Together with the histone H3.1 protein, that stat earns them the title of most persistent mammalian intracellular protein. The authors speculate that disassembly of entire NPCs might not be practical for the cell because dismantling these key components could jeopardize the integrity of the nuclear envelope. Important nuclear substructure, possibly including epigenetic depots critical for transmitting information beyond the lifetime of an individual cell might then be compromised. They also note that long-lived proteins might also be sources of vulnerability within the proteome, particular those that would be exposed to harmful metabolites or chemical interlopers. Identification of these elements may therefore be important in understanding the aging process in postmitotic cells.center_img Citation: Protein lifetime and the stability of cell structures (2013, September 4) retrieved 18 August 2019 from https://phys.org/news/2013-09-protein-lifetime-stability-cell.html Explore further © 2013 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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A close up look at how bacteria make ice

first_img(Phys.org)—A combined team of researchers from Germany and the U.S. has taken a closer look at a type of bacteria that is able to cause ice to form, sometimes even under conditions above the normal freezing point. Explore further In their paper published in the journal Science Advances, the team describes the technique they used that allowed them to watch very closely what occurs as the bacteria promote ice formation and their discovery of the means by which the bacteria cause it to come about.Scientists have known for some time that some bacteria can promote the growth of ice crystals (they have been used to help create snow for ski resorts, as one example), but until now, the exact mechanism has not been closely studied. In this new effort, the researchers used a device called a sum frequency generation spectrometer to get a better look—it allows for a very close up view of a process as it takes place. In this instance, they watched as samples of Pseudomonas syringae went to work on both airborne water droplets and those that were on a surface. In so doing, they discovered that the bacteria use two different techniques to promote ice formation.The first technique involved a layer of proteins that surrounded the body of the bacteria—some were hydrophobic and others were hydrophilic—the opposing forces allowed the bacteria to shuttle water molecules around like a tiny tugboat, coaxing them into formations that were conductive to crystal growth.The second technique involved using vibrational energy to actually remove heat from the area surrounding the molecules that they had lined up, leaving them colder, which resulted in ice crystal formation at temperatures that were above freezing.The researchers note that the bacteria also have antifreeze proteins in their bodies to keep themselves from freezing. They add that their findings may have implications for Earth scientists, as ice causing bacteria play a major role in the creation of ice crystals in the atmosphere, and in frost formation on plants. More research into the process could also lead to the development of icing, or even de-icing products. Journal information: Science Advances Ice crystals: Max Planck researchers discovered that certain bacteria can affect the ordering and the dynamics of water molecules in water droplets. Thus, ice crystals develop already at zero degrees Celsius or just below, and not at minus 37 degrees Celsius as in pure water. Protein molecules at the surface of the bacteria are responsible for this process. Credit: R. Eckl © 2016 Phys.orgcenter_img More information: R. Pandey et al. Ice-nucleating bacteria control the order and dynamics of interfacial water, Science Advances (2016). DOI: 10.1126/sciadv.1501630AbstractIce-nucleating organisms play important roles in the environment. With their ability to induce ice formation at temperatures just below the ice melting point, bacteria such as Pseudomonas syringae attack plants through frost damage using specialized ice-nucleating proteins. Besides the impact on agriculture and microbial ecology, airborne P. syringae can affect atmospheric glaciation processes, with consequences for cloud evolution, precipitation, and climate. Biogenic ice nucleation is also relevant for artificial snow production and for biomimetic materials for controlled interfacial freezing. We use interface-specific sum frequency generation (SFG) spectroscopy to show that hydrogen bonding at the water-bacteria contact imposes structural ordering on the adjacent water network. Experimental SFG data and molecular dynamics simulations demonstrate that ice-active sites within P. syringae feature unique hydrophilic-hydrophobic patterns to enhance ice nucleation. The freezing transition is further facilitated by the highly effective removal of latent heat from the nucleation site, as apparent from time-resolved SFG spectroscopy.Read press release Chipping away at the secrets of ice formation This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: A close up look at how bacteria make ice (2016, April 25) retrieved 18 August 2019 from https://phys.org/news/2016-04-bacteria-ice.htmllast_img read more

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Solar cell mystery solved expected to greatly increase efficiency

first_img Explore further But in a new study published in Science Advances, Dong Shi et al. have taken a closer look at spiro-OMeTAD and found that it still has a great deal of untapped potential. For the first time, they have grown single crystals of the pure material, and in doing so, they have made the surprising discovery that spiro-OMeTAD’s single-crystal structure has a hole mobility that is three orders of magnitude greater than that of its thin-film form (which is currently used in solar cells). “This paper reports a major breakthrough for the fields of perovskite and solid-state dye-sensitized solar cells by finally clarifying the potential performance of the material and showing that improving the crystallinity of the hole transport layer is the key strategy for further breakthroughs in device engineering of these solar cells,” Osman Bakr, a professor of engineering at King Abdullah University of Science and Technology (KAUST) in Saudi Arabia and leader of the study, told Phys.org. The findings suggest that, at least in the short term, the time-consuming process of designing and synthesizing radically new organic hole conductors as replacements to spiro-OMeTAD may not be necessary.In general, perovskite solar cells and dye-sensitized solar cells are made of three critical layers. Two of these layers—the electron-transporting layer and the light-absorbing layer—are well-understood structurally. However, the mesoscale packing structure of the hole-transporting layer, which is usually spiro-OMeTAD, has so far eluded researchers, and consequently its charge transport mechanisms have remained a mystery.In the new study, the researchers figured out a way to grow pure single crystals of spiro-OMeTAD by dissolving the spiro-OMeTAD in a carefully chosen solvent. They then placed this vial inside a larger vial containing an antisolvent, in which spiro-OMeTAD does not dissolve as well, and allowed the antisolvent vapor to slowly diffuse into the inner vial. Eventually the solution in the inner vial becomes supersaturated, so that not all of the spiro-OMeTAD can stay dissolved, causing the spiro-OMeTAD to crystallize. The researchers then performed a variety of measurements on the crystals to investigate their charge transport mechanisms and other properties.The results are much more encouraging than expected, in many ways running contrary to the conventional wisdom based on the material’s large-scale structure, which suggested that the material had reached its limits. Although the method used here to grow single crystals cannot be performed at a large scale, the researchers predict that similar methods that use an antisolvent to trigger crystallization could be used to enhance the crystallinity of the thin-layer spiro-OMeTAD, improving its hole mobility in order to make more efficient solar cells.”These astonishing findings open a new direction for the development of perovskite solar cells and dye-sensitized solar cells by showing the still untapped potential of spiro-OMeTAD,” Bakr said. “They unravel a key mystery that has confounded the photovoltaic community for the last 17 years.” (Left) The set-up used to grow single crystals of spiro-OMeTAD, based on antisolvent vapor-assisted crystallization. (Right) Single crystal structure of spiro-OMeTAD. Credit: Shi, et al. ©2016 AAAS Pinholes be gone More information: Dong Shi, et al. “Spiro-OMeTAD single crystals: Remarkably enhanced charge-carrier transport via mesoscale ordering.” Science Advances. DOI: 10.1126/sciadv.1501491AbstractWe report the crystal structure and hole-transport mechanism in spiro-OMeTAD [2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenyl-amine)9,9′-spirobifluorene], the dominant hole-transporting material in perovskite and solid-state dye-sensitized solar cells. Despite spiro-OMeTAD’s paramount role in such devices, its crystal structure was unknown because of highly disordered solution-processed films; the hole-transport pathways remained ill-defined and the charge carrier mobilities were low, posing a major bottleneck for advancing cell efficiencies. We devised an antisolvent crystallization strategy to grow single crystals of spiro-OMeTAD, which allowed us to experimentally elucidate its molecular packing and transport properties. Electronic structure calculations enabled us to map spiro-OMeTAD’s intermolecular charge-hopping pathways. Promisingly, single-crystal mobilities were found to exceed their thin-film counterparts by three orders of magnitude. Our findings underscore mesoscale ordering as a key strategy to achieving breakthroughs in hole-transport material engineering of solar cells. © 2016 Phys.orgcenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Science Advances Citation: Solar cell mystery solved, expected to greatly increase efficiency (2016, April 24) retrieved 18 August 2019 from https://phys.org/news/2016-04-solar-cell-mystery-greatly-efficiency.html (Phys.org)—For the past 17 years, spiro-OMeTAD, has been keeping a secret. Despite intense research efforts, its performance as the most commonly used hole-transporting material in perovskite and dye-sensitized solar cells has remained stagnant, creating a major bottleneck for improving solar cell efficiency. Thinking that the material has given all it has to offer, many researchers have begun investigating alternative materials to replace spiro-OMeTAD in future solar cells.last_img read more

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Energetic cost of the entatic state of cytochrome c quantified

first_img Explore further Potential therapeutic target for Parkinson’s disease (Phys.org)—A team of researchers at Stanford University has used ultrafast x-ray absorption and emission spectroscopy to quantify the entatic state of cytochrome c. In their paper published in the journal Science, the group outlines their procedure and what they learned. Kara Bren and Emma Raven with the University of Rochester and University of Leicester respectively offer a Perspective piece on the work done by the team in the same journal issue, and outline some of the implications regarding the role that the protein plays in cell life and death. More information: Metalloprotein entatic control of ligand-metal bonds quantified by ultrafast x-ray spectroscopy, Science (2017). science.sciencemag.org/cgi/doi … 1126/science.aam6203AbstractThe multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and apoptosis, switching function by modulating bonding between a heme iron and the sulfur in a methionine residue. This Fe–S(Met) bond is too weak to persist in the absence of protein constraints. We ruptured the bond in ferrous cyt c using an optical laser pulse and monitored the bond reformation within the protein active site using ultrafast x-ray pulses from an x-ray free-electron laser, determining that the Fe–S(Met) bond enthalpy is ~4 kcal/mol stronger than in the absence of protein constraints. The 4 kcal/mol is comparable with calculations of stabilization effects in other systems, demonstrating how biological systems use an entatic state for modest yet accessible energetics to modulate chemical function. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.orgcenter_img Citation: Energetic cost of the entatic state of cytochrome c quantified (2017, June 23) retrieved 18 August 2019 from https://phys.org/news/2017-06-energetic-entatic-state-cytochrome-quantified.html A change in the active-site conformation turns cytochrome c from an electron shuttle in respiration to a peroxidase enzyme for apoptosis. Credit: (c) Science  23 Jun 2017: Vol. 356, Issue 6344, pp. 1236 , DOI: 10.1126/science.aan5587 Journal information: Science Cytochrome c is a protein that exists in many plants, animals and unicellular organisms. In humans, its main purposes are ferrying electrons in mitochondria and assisting with apoptosis (normal cell death and the processes surrounding it.) These two functions have been shown in prior efforts to rely on the position of methionine residue. When sulfur works with iron, the protein is ready to transfer electrons. Otherwise, it engages in peroxidase activities. In this new effort, the researchers sought to better understand the energetics of the protein by probing the iron and sulfur bond. Entatic states, Bren and Raven point out, are very important in bioinorganic chemistry—it actually translates to something that is stretched when subjected to tension.To better understand the bond between the two elements, the researchers temporarily forced them apart using a Linac Coherent Light Source X-ray free electron laser and then timed how long it took the two components to reform using iron X-ray emission spectroscopy. They found that the environment in which they existed boosted bond strength by four kilocalories per mole, which was enough to allow the protein to toggle between its functional states and to quantify the energy cost of the entatic state.As Bren and Raven note, the results of the study have implications regarding the role that cytochrome plays in respiration, which they relate to living and apoptosis, which they relate to death. To promote continued living the protein helps to maintain a certain reduction potential. For apoptosis, the entatic state is disrupted allowing peroxidase activity to be enhanced.last_img read more

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Shes a small wonder

first_imgShe is just 10. But by the touch of her hand she can spell magic on a lump of clay. And with fire and colour she adds expressions. Avani Singhania just wrapped up her exhibition of ceramic works at the second edition of the her show titled- Pots, Platter And Me Returns at the Experimental Arts Gallery, India Habitat Centre.A student from Vasant Valley School, Avani followed her passion for pottery at the nascent age of 6- years under the guidance of Ela Mukherjee, a famous ceramic artist and a winner of Charles Wallace awards. Also Read – ‘Playing Jojo was emotionally exhausting’Enthusiastically explaining her works, Avani said, ‘I love experimenting with colours and shapes. I first got to know about pottery in a school exhibition and found it very fascinating. My parents were very supportive and sent me various workshops to learn more about pottery. During one of the workshops I met my teacher Ela Mukherjee and she has been my inspiration ever since.’At the exhibition she displayed an array of colourful tea pots, cups and saucers, decorative items shaped like hearts, ovals and pen-stands in ceramics. The collection also includes bowls, coffee mugs, diyas, candle stands in bright colours to go hand in hand with the festive season.Avani has been learning pottery since 2009 and has already put up one exhibition in 2011 in Mumbai and once in Delhi in 2012. She has been taking regular classes and wishes to explore more about the art.Age is just a number for Avani as she stunned visitors at her exhibition with her wonderful talent of shapes and colour.last_img read more

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Comedy history class

first_imgGet ready for a laughter dose as Behroopiya Entertainers in association with Comedy Central brings the standup comedy show – India 3D – Last Three Decades of Change. The show features comedians – Amit Tandon and Appurv Gupta.India 3D – Last three Decades of Change highlights how life and lifestyle has changed in India over the last three decades. As tablet moved from being medicine to mobile, smartness moved from people to phones, hobby moved from books to Facebook, our world has changed more than ever before. A woman’s role has changed in the household and expectations from an Indian man have evolved. Between the two of them they present views of a youngster and a conventional ‘well settled’ middle aged man. From technology to lifestyle to relationships, the artistes will talk about all aspects of a middle class Indian.  So book your tickets soon.Where:  Kamani Auditorium, Mandi House When: 10 October Timing:  8 pmlast_img read more

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Chia your daily dose of happiness

first_imgDepression has not been taken with much seriousness for long, due to social stigma or lack of awareness and diagnosis but is now an acknowledged malady that affects growing numbers of people across the world. In a mental health survey released by the National Institute of Mental Health and Neurosciences, one in every 20 Indians suffers from some form of depression. Not just that, as a country India was ranked 122nd in World Happiness Report released last month. If more evidence were needed, the UN has declared Depression as the theme of World Health Day 2017. Also Read – Add new books to your shelfDepression can be due to various reasons ranging from endogenic to environmental causes. Sometimes environmental situations can trigger a genetic predisposition and cause the onset of depression. However, there is now growing agreement that food plays a significant role in brain chemistry. A good food selection with the right quantities and combinations of food groups helps in better wellness resulting in effective ability to handle and recover from stresses. Being happy goes hand in hand with optimum cognitive performance, and although one cannot alter the environmental stress one is exposed to, consistent low-intensity stresses of day to day life is often a challenge experienced by all. However, right foods prevent the onset of depression or help alleviate depression. Also Read – Over 2 hours screen time daily will make your kids impulsive According to growing consensus in the scientific and nutrition community, Omega-3 fats are an effective nutrient in our diet that provides adequate protection against depression. Foods rich in omega-3 are fish and a few plant produce. Chia is one of the richest sources of plant based omega-3 fats for vegetarians. Omega-3 fats have shown a positive role in improving mood in people suffering from depression. It is estimated that some cultures who have been consuming foods such as Chia as part of their regular diet do better than others in mental health. Chia is an ancient grain and was an essential part of the Aztec culture with a presence in their religious practices, daily food and special foods as well as food for the ancient Aztec warriors. Over the centuries, witnessing many a military invasion, the crop lost its presence and was revived only in the recent past. Chia seeds occurs in nature in black, mottled and white forms with white seeds having an edge over the rest. Due to its high import costs, superfoods have been inaccessible to a majority of consumers in India, leave alone the common man. However all that may be about to change.India’s premier nutrition research development organisation, Central Food Technology Research Institute, has developing agro-technologies to grow superfoods in Indian conditions, and as a pilot programme provided Chia seeds for free to Indian farmers. CFTRI has developed blue flower, white seed Chia lines which blend seamlessly into foods, which have a better market globally. Farmers from across the nation have benefited with better incomes due to the seeds they received and cultivated with CFTRI agro-technology.Chia seeds do not require post-harvest processing and can be directly consumed after cleaning. It is highly versatile and can be consumed by adding to our daily foods. Chia upon adding to water becomes a gel that is easy to drink. One can add about 3-gram Chia to a glass of water and allow the water to rest for about 10 minutes; the seeds form a transparent gel that can be easily consumed. Seeds can blend well in into fruit juices, smoothies, shakes, buttermilk, puddings and bakery products like bread and cakes. The neutral taste of the seed helps in seamless blending into all food products. On an average, an adult needs about 1-1.6 gram of omega-3 fat daily and that can be met by simply having 1 teaspoon of chia seeds dissolved in water or in any other form.One of the main focus of CFTRI’s work on superfoods like Chia is to make it easily available and affordable to Indians at large so that it can gain the currency of a stable like a dal or pulses of everyday use. (Courtesy: Prof. Ram Rajasekharan)last_img read more

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Know why women are better at reading mind

first_imgEver wondered how your wife or partner is able to read your thoughts and emotions just by looking at your eyes? Her ability to interpret may be the result of a gene influence, say researchers, one of Indian-origin.The findings showed that the genetic variants on chromosome 3 in women are associated with their ability to read the mind in the eyes — known as cognitive empathy.The closest genes in this tiny stretch of chromosome 3 include LRRN1 (Leucine Rich Neuronal 1) which is highly active in a part of the human brain called the striatum — which has been shown using brain scanning to play a role in cognitive empathy, the researchers said. Also Read – Add new books to your shelf”This is an important step forward for the field of social neuroscience and adds one more piece to the puzzle of what may cause variation in cognitive empathy,” said Varun Warrier, doctoral student at the University of Cambridge. Scientists have built upon a study first performed 20 years ago, called the “Reading the Mind in the Eyes” test.For the new study, published in the journal Molecular Psychiatry, the team analysed cognitive empathy in 89,000 people on this test. Also Read – Over 2 hours screen time daily will make your kids impulsiveThe results confirmed that women on average do score better on this test because of gene’s influence.In addition, the researchers found that genetic variants that contribute to higher scores in the test also increase the risk of anorexia, but not autism, the researchers noted.”We are excited by this new discovery, and are now testing if the results replicate, and exploring precisely what these genetic variants do in the brain, to give rise to individual differences in cognitive empathy,” explained Simon Baron-Cohen, Professor at the University of Cambridge.last_img read more

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Food allergy can become fatal for your kid

first_imgA 13-year-old Indian-origin boy in London died last month after suffering a severe allergic reaction to a piece of cheese. According to media reports, Karanbir Cheema was allergic to wheat, gluten and dairy and his condition was well known at school but he came in contact with the allergen in cheese as it was allegedly forced on him by a schoolmate.Food allergy or intolerance, which can cause symptoms ranging from a harmless skin rash to a potentially lethal anaphylactic shock, are estimated to affect four to six per cent of children and four per cent of adults, according to the US Centers for Disease Control and Prevention (CDC).If left untreated, a food allergy can turn fatal, especially in children, because the body’s immune system considers the proteins and complex carbohydrates present in the food as foreign.”It is only in rare cases that one can get a severe allergic response to any food allergen. Food items like cheese have other ingredients which may have caused severe allergic reaction. Commonly mild allergy, however, does not cause such severe reactions,” said Vivek Raj, Director (Gastroenterology), Max Super Speciality Hospital.According to the US Food and Drug Administration (FDA), there are eight foods that are common for allergic reactions in a large segment of the sensitive population. These include, peanuts, tree nuts, eggs, milk, shellfish, fish, wheat and their derivatives, soy and their derivatives, and sulphites (chemical-based, often found in flavours and colours in foods) at 10 parts per million (ppm) and over.These can cause several types of allergies such as skin manifestations which include rashes, swelling and itching, respiratory symptoms including wheezing, bronchospasm and choking and gastrointestinal symptoms including cramping, vomiting and diarrhoea. Some also cause low blood pressure which manifests as light-headedness, dizziness or even a fainting spell.Allergy to any food item may cause bronchial secretions, which can lead to bronchospasm – a sudden constriction of the muscles in the walls of the bronchioles in the respiratory tract.”As a result, the patient experiences choking and breathing difficulty, which, if not treated timely, may increase the risk of death,” added Rakesh Gupta, Senior Consultant, Apollo Hospitals.Further, children are much more vulnerable to food allergies than adults as the allergies fade away by adulthood.”As children grow older, they outgrow some of the allergies as their immune system matures. Also, the allergens are identified in childhood and then the person learns to avoid those as an adult,” Raj noted. However, allergies are not just hereditary but may be related to gender, according to recent research published in the Journal of Allergy and Clinical Immunology.The study revealed that the genetic risk of a child having allergies doubles if the parent of the same sex is an allergy sufferer. Thus, mothers pass the risk of allergies to their daughters, as do fathers to their sons.Moreover, food allergies can worsen other conditions such as asthma and diabetes. If a patient already has other allergy-linked conditions like asthma, then the impact of food allergy can be more, doctors said. “As there is no cure to food allergy, the only way to prevent it is not to eat that food item,” suggested Ritika Samaddar, a Delhi-based nutritionist.”The allergy can be confirmed by skinprick tests and/or bloods tests to measure the allergy antibodies,” she added. Because fatal and near-fatal food allergy reactions can occur at school or other places outside the home, parents of a child with food allergies need to make sure that their child’s school has a written emergency action plan. The plan should provide instructions on preventing, recognising and managing food allergies and should be available in the school and during activities such as sporting events and field trips, experts suggested. However, “if any allergic item is consumed, the patient should be immediately rushed to the hospital. No drug should be taken without a doctor’s prescription”, Gupta said.last_img read more

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Be draped in these puja classics

first_imgIt is the time of the year to look your best and create an aura in whichever Pandal you visit or party you attend with friends, family or with your beloved. With Durga Puja around the corner, the fashionistas are gearing up to shop their favourite attires. And what better than to don a saree during this grand celebration. To add to the festivities, leading retail saree store of Bengal, Indian Silk House Agencies, launched Pujor Shaaj, their Durga Puja special collection. Renowned actor, Konineeca Banerjee unveiled the special collection in the presence of Pratibha Dudhoria, Director, Indian Silk House Agencies. Also Read – Add new books to your shelf “The Pujor Shaaj collection is inspired from the goddesses Durga, Saraswati and Laxmi. The designs are exquisite and unique, which will appeal to the saree lovers across the globe. This year we are also focusing on our youth as well by providing them with sarees that are light, comfortable, trending, and perfect for any occasion and at a very reasonable price, which they can wear with great panache”, said Dudhoria.The exclusive Pujor Shaaj collection comprises of Kanjivaram, Arni Silk, Garad, and Uppada in a range of Rs 2500 and above. Gadwal, which starts from Rs 4500, and Kora, Matka, Chanderi, whose range starts from Rs 1000. Printed fabric starts from Rs 2000, whereas, Tussar, Handloom, Maheshwari, Benarasi and Katan sarees in varied colours and outstanding designs are available at a starting rate of Rs 3000. This new collection will be available across Indian Silk House Agencies outlets in Rashbehari Avenue, Barasat, New Market, Gorabazar, and Kanchrapara.Indian Silk House Agencies also has a range of costume jewelry available to complement these sarees.last_img read more

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Charkha to provide jobs to five crore women

first_imgThe Minister of State (Independent Charge) for Micro, Small and Medium Enterprises Giriraj Singh, on Monday, said that following the ‘Khadi for Fashion’ call by Prime Minister Narendra Modi, the ministry had planned to connect at least five crore village women to Charkha (spinning wheel).Addressing the Gandhi Jayanti Celebrations at Khadi Bhawan in Connaught Place, the minister said that Khadi has now become popular among younger generation too. “For a significant span of time Khadi was meant for either dadaji (older ones) or netaji (politicians). But, due to the initiatives and appeals made by our Prime Minister – who is himself the latest USP of Khadi –Khadi has now become a fashion trend among the youth,” he said, adding, “Even the results speak. The previous governments could increase the sale by only 70 percent in 10 odd years, but we enhanced it to 90 percent.” Also Read – Add new books to your shelfSpeaking of solar charkhas, the minister said that it would provide employment to at least five crore village women in the coming five years. “With five pilot projects at Varanasi, Nawada and other places, we are already on our heels with this project. It will ensure a regular income between Rs 6000 and Rs 10,000 to each of the women,” he said. The minister claimed that in efforts to make Khadi a fashion brand across the globe, the department is in regular contact with all leading fashion institutes of the country. Also Read – Over 2 hours screen time daily will make your kids impulsiveSingh further added that even in Africa, as a part of centenary Year celebrations of Gandhiji’s Swadeshi Movement, the High Commission of India in Uganda, in association with the Republic of Uganda, is unveiling the Gandhi Charkha – gifted by Khadi and Village Industries Commission (KVIC) – at the Gandhi Heritage Site at Jinja in Uganda. Khadi and Village Industries Commission (KVIC) Chairman Vinai Kumar Saxena, in his address, said that Khadi has been spreading its wings in all directions for creating maximum job opportunities for the artisans. “Since sanitation and Khadi was close to Mahatma Gandhi’s heart, the KVIC is all set to take his legacy forward,” he said, adding, “We have also taken Prime Minister’s call of ‘Sweet Revolution’ very seriously and we are trying to give a major push to our ‘Honey Mission’ in the coming days.” Arun Kumar Panda, secretary, MSME, also laid stress upon enhancing the total turnover of Khadi and Village Industries. Earlier, the minister inaugurated 60 Khadi outlets – which were renovated and re-launched during the completion of KVIC’s 60th anniversary and a Khadi outlet at Chaudhary Charan Singh International Airport at Lucknow, through remote device. He also handed over the cheques to five artisans each from two Khadi institutions of Uttar Pradesh and Haryana, under the new sales initiatives undertaken by KVIC. Later, he inaugurated a Honey Parlour – showcasing several qualities of honey – at Palika Bazaar.last_img read more

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A magnificent range of Diwali hampers

first_imgAdding to your celebration and joy, Mister Chai is presenting a magnificent range of Diwali Hampers offering gourmet assortments and pure joy. This Diwali, make your loved ones feel special and gift them hampers that matches their personality, tailored to their taste and filled with luxuries and love. Exuding surprise and elegance, the spectacular festive hamper range comprises of ‘The Globe Trotter’, ‘The Entertainer’ and ‘The Free Spirit’ starting at INR 5000 plus taxes. Also Read – Add new books to your shelf’The Globe Trotter’ is for those businessmen and women in your circle who travels the world and are fond of those little treats. Generously filled with fine nuts, chocolates and a bottle of happiness, this is a perfect gift for the globe trotters. If you have those friends who love spreading a hearty laughter to your life, ‘The Entertainer’ Diwali gift hamper is the choice. It offers some delicious chocolates, macaroons, cookies, nuts, and tea. ‘The Free Spirit’ hamper is the choice you can make for those you know exceptionally well. Custom-made and skillfully craft a Diwali hamper for your loved ones, with their favourite ingredients and drinks. Each gifting has equal grandeur, finesse and uniqueness, filled with an alluring gourmet treat to make your festival truly delightful.last_img read more

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Cherishing Indian culture through music and dance

first_imgDance, music, and art have always played a vital role in developing our aesthetic and artistic senses and perceptions. Rigchhandam, a premier institution excelling in dance, music, art, and elocution – which is a cultural wing of South Jodhpur Park Academy – presented ‘Alochayar Shure’, ‘Prayash’ and ‘ Samanyo Khoti’ in their 17th Annual program held in GD Birla Sabhaghar.It was the coming together of like-minded people with one basic objective in mind – propagation of traditional Indian values through Indian music and dance. The Academy members were honoured to have renowned Rabindrasangeet exponent Srabani Sen as its President, with the expectations that under her able guidance, they will be able to make progress in the right direction, and fulfill the designated objectives and aspirations. Also Read – Add new books to your shelfThe dance section is being looked after by Subhra Mandal, a disciple of Kathak legend Birju Maharaj as well as Shrimati Amala Shankar, the doyen of the Uday Shankar ‘Creative’ style of dance. “Our main motto is to inculcate Indian values in our children and fellow members. Our rich culture and traditions should be cherished by one and all. With a batch of around 135 students from school kids to octogenarians, we believe that music plays a strong part in our daily lives, strengthening the heart and mind,” said co-founder Subhra Mandal. While tradition in these creative fields holds a unique position, it is very much true that innovation and new ideas add a relevant and modern dimension to these artistic forms of expression. The coming together of old and new is surely a healthy sign in the creative world.last_img read more

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Michael Jackson and Paul McCartneys Feud Over Beatles Song Rights

first_img“Michael, we’re not gonna fight about this okay?” “Paul, I think I told you, I’m a lover, not a fighter.”“She told me that I’m her forever lover,” said Paul “You know, don’t you remember?”“Well, after loving me,“ Michael answered, “she said she couldn’t love another.”“Is that what she said?”“Yes, she said it, you keep dreaming.”This playful exchange happened between former Beatle Paul McCartney and Michael Jackson during the 1982 hit music video “The Girl is Mine.” The video featured a make-believe rivalry between the two pop stars over the affections of a young lady.Paul McCartney. Photo by Oli Gill CC BY-SA 2.0Three years later, McCartney and Jackson would lock horns in a real-world battle, but not over a girl.According to Billboard Magazine, the conflict started in 1985, when Jackson paid nearly $50 million to ATV Music (now called “Sony Music”) to purchase a 4,000-song catalog.Michael Jackson performing his song “Jam” as part of his Dangerous world tour in Europe in 1992. Photo by Casta03 CC BY-SA 3.0The catalog contained 250 songs by the John Lennon/Paul McCartney songwriting duo. It also included tracks by Elvis Presley, the Rolling Stones, and Bruce Springsteen.Paul McCartney was not happy about having his own songs purchased out from under him by another artist. To add more insult to injury, Jackson had actually outbid McCartney on the deal.John Lennon (left) and Paul McCartney (right) in 1964.The fact that McCartney and Jackson were friends and had recorded multiple songs together – including: “Say, Say, Say,” “The Girl is Mine,” “The Man” and “Girlfriend,” – surely made the deal more of a betrayal. Their friendship never recovered.But how did Paul McCartney, one of the most famous pop songwriters of the 20th century, end up in a position where another artist could buy the rights to his songs?When The Beatles’ debut album “Please Please Me” was released in March 1963 their manager, Brian Epstein, published the songs with the company Northern Songs.Please Please Me, side 1, with original Parlophone gold and black label. Photo by Parlophone Records CC BY-SA 3.0The company was primarily owned by Epstein himself and by publisher Dick James, along with John Lennon and Paul McCartney. George Harrison and Ringo Starr – the other two Beatles songwriters – split ownership of the remaining 40 percent.Northern Songs became a public company in 1965, with Lennon and McCartney owning 15 percent each and with Harrison and Starr sharing a small percentage. Harrison was not happy about this, and even wrote a song about his meager cut in the deal.Jackson performing in June 1988. Photo by Zoran Veselinovic CC-BY-SAIn 1969, Dick James sold his stake in the company to ATV Music. John Lennon and Paul McCartney tried to outbid ATV, but they didn’t have enough money. After ATV had taken control of the Beatles’ song catalog, Lennon and McCartney sold their company stakes to ATV as well.So, when ATV Music went up for sale, they offered McCartney one more chance to bid on the rights to the Lennon-McCartney song catalog. This is when Michael Jackson stepped in and paid $47.5 million to become the owner of the catalog.McCartney and Lennon, 1964.In 2006, the matter became more complicated for McCartney when Michael Jackson, faced with a potential bankruptcy, agreed to sell half of his ownership in the company back to Sony/ATV. This would give Sony 75 percent ownership of the Lennon-McCartney song catalog, which, according to The New York Times, was then worth about $1 billion.McCartney was left with only one shot to get his songs back. According to the United States Copyright Act of 1967, any publishing rights to songs written before 1978 could be regained by their author after 56 years. Since the first Beatles songs had been written between the years of 1962 and 1963, McCartney would have to wait until 2018 before he could hope to get his songs back.Michael Jackson’s star on the Hollywood Walk of Fame.Then, in 2009, Michael Jackson died by overdosing on the anesthetic “propfol” – he was 50 at the time. Jackson’s share of the Lennon-McCartney catalog became a part of his estate, which was controlled by his attorney John Branca and by John McClain.In 2015, McCartney began the fight to reclaim 32 Beatles songs written in 1962. In 2016 Sony finally agreed to pay $750 million to buy out the half of Sony/ATV which was owned by the Jackson Estate. This made Sony the sole owner of 750,000 songs, including the Lennon-McCartney catalog.Read another story from us: A Hard Day’s Night (in Jail): Paul McCartney Arrested for Arson in 1960This deal marked the official end of Jackson and McCartney’s battle – which had literally become a fight to the death. According to Billboard Magazine, Sir Paul McCartney finally regained the Beatles’ song catalog in June of 2017, just a few days before his 75th birthday.last_img read more

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VIDEO A Kentucky bar instantly transformed into the saddest place on Earth

first_img Advertisement Sports can give fans indescribable joy, and gut wrenching misery. Kentucky fans experienced both in a matter of 10 seconds at the end of their Elite 8 tournament game against North Carolina.A camera set up inside of a Kentucky bar captured the entire range of emotion, from their ecstasy after Malik Monk’s game-trying three, to getting their heart ripped out by UNC walk-on Luke Maye on the next possession.Watch how quickly this party turns from the ecstasy to agony. It hurts to watch, unless you hate Kentucky.last_img read more

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