4:54 More From Roadshow 2020 Chevy Silverado Diesel first drive: A smooth and torquey operator 2020 Toyota Tacoma gets a new face, tech Top newsLittle red Corvette: Chevy’s new, mid-engine C8 Corvette is finally, finally here. It’s a bargain, too: Even more amazing than the new Corvette’s performance is the fact that it’ll start around $60,000 when it goes on sale later this year.Solar Sonata: Hyundai’s swoopy new sedan gets a hybrid version complete with solar panels on its roof.Electric ‘Slade: New reports suggest Cadillac’s next Escalade SUV could be offered with a electric powertrain.Super-efficient Silverado: Chevy confirms its diesel-powered Silverado 1500 is the most fuel-efficient fullsize pickup in the US.Lotus flowers: Say hello to the 2020 Evora GT, the company’s latest US offering.Kia wants a truck: A report out of Australia suggests Korean automaker Kia might launch a small pickup in 2022 or 2023. 2019 Chevy Silverado 2.7T review: Turbo tradeoffs Now playing: Watch this: 2020 BMW 2 Series Gran Coupe PrototypeBMW’s new 2 Series sedan — or Gran Coupe, in the company’s parlance — will make its debut at the Los Angeles Auto Show in November. Ahead of that premiere, we take a spin in a colorful, camouflaged prototype in Germany to see if the 2GC’s front-wheel-drive platform hinders its performance. Spoiler alert: it doesn’t.Click here to read our 2020 BMW 2 Series Gran Coupe prototype first-drive review. Post a comment 0 The best trucks for towing 32 Photos Now playing: Watch this: 73 Photos 6:29 2019 Honda CR-VHonda’s new CR-V is a couple years old, but it’s still a top contender in the compact SUV class. It offers solid driving dynamics, great infotainment tech, and a usable and refined interior.Click here to read our 2019 Honda CR-V in-depth review. 2020 VW Atlas Cross Sport goes to Death Valley Tags 2:24 2020 Toyota TacomaOK, so maybe the Toyota Tacoma isn’t the freshest truck on the block. We still love it for its rugged capability and handsome good looks. For 2020, Toyota gives the Tacoma a big infotainment and driver assistance tech upgrade, and we test the truck’s off-road prowess on the trails of Colorado and Utah. We even take the updated 2020 Toyota 4Runner SUV for a spin, as well.Click here to read our 2020 Toyota Tacoma first drive review. NASA astronaut Scott Kelly on Corvettes, manual transmissions… 55 Photos 2020 VW Atlas Cross Sport in the desertVolkswagen will introduce a five-passenger version of its Atlas SUV next year. Ahead of that, we tag along while VW engineers complete hot-weather testing of the new SUV in California’s Death Valley. Click here to read the full story. 2020 Chevrolet Corvette blends the new and the familiar Top videos Share your voice Astronaut Scott Kelly talks CorvettesIs there really any comparison to launching a car and launching a rocket? Former NASA astronaut Scott Kelly says yes, and he sat down with editor-in-chief Tim Stevens to explain.Click here to read the full story. 2019 Audi RS5 SportbackThe Audi RS5 Sportback is an amazing car. In fact, its only flaw might be that it doesn’t have any. Is this four-door sports car too good for its own good? Associate editor Andrew Krok explains.Click here to read the full story. 2019 Audi RS5 Sportback is a goody two-shoes 22 Photos Roadshow 2019 Honda CR-V: A can’t-miss small SUV option The 2020 BMW 2 Series Gran Coupe hides in plain sight 2020 Toyota 4Runner first drive: Same as it ever was — mostly 33 Photos Enlarge ImageAll eyes are on Chevy’s mid-engine C8 Corvette. Steve Fecht/Chevrolet Welcome to Roadshow’s week in review, where we take a look back at the biggest stories from the past seven days. While Chevy’s new mid-engine Corvette technically debuted last week, we’ve had plenty of followup information to report, and it’s proved to be one of the hottest items from the past seven days. Toyota’s new Tacoma and 4Runner kicked off a week of hot reviews, and we drove a pair of prototypes previewing some soon-to-be-revealed new cars.Here’s a look at our most important stories from July 21 to 27, 2019.Top reviews Now playing: Watch this: BMW Cadillac Chevrolet Honda Toyota
Actress Sophie Turner from the HBO series “Game of Thrones” arrives at the 68th Primetime Emmy Awards in Los Angeles, California U.S., September 18, 2016.ReutersSophie Turner seems to have left winter far behind. The X-Men: Dark Phoenix star was spotted with Priyanka Chopra.Reportedly, the duo was spotted in Miami enjoying a pool day. Sophie and Priyanka were both seen having fun while showcasing their enviable figures in gorgeous swimwear.The “Game of Thrones” star was seen showing off her body in a skimpy forest green two piece. Sophie’s triangular top modestly concealed her ample cleavage and she teamed the look with a matching pair of bikini bottoms. Sophie Turner accessorized her look with some gold necklaces. However, her wedding rings were absent from her person.Sophie had her taut stomach on display and was not seen with her wedding rings but accessorized with some gold necklaces. She was accompanied by sister-in-law Priyanka Chopra who looked stunning in a burgundy swimsuit. The wife of Nick Jonas, flaunted her enviable curves in a burgundy colored one-piece that drew attention to her cleavage and curvaceous frame.Sophie Turner and Joe Jonas were recently spotted in as they locked lips for all to see. Reportedly, the pair was photographed looking madly in love while sharing a kiss over lunch on their honeymoon. While grabbing a bite to eat in Positano, Italy, Joe Jonas could be seen planting a passionate kiss on the lips of the Game of Thrones star. But the PDA didn’t stop there, Joe Jonas seemed to be having a real hard time trying to keep his hands off Sophie. Priyanka Chopra in Nick Jonas’ SuckerPriyanka Chopra (@priyankachopra/Instagram)During the rest of their meal, Joe was seen planting a kiss on Sophie’s hands, and she enjoyed herself an Italian espresso.”Sophie and Joe are having the time of their lives on their romantic honeymoon getaway,” an insider to the couple told HollywoodLife exclusively. And it looks like the vacation is doing wonders for Sophie, who had confessed to Dr. Phil recently that she really needed a break. “They have both been working so hard for so long and have been so focused on their careers that they really needed this time away to just enjoy married life.”Well, it looks like Sophie doesn’t always need Joe to have fun. You can check out the pics here: Sophie Turner – bikini candids on vacation in Miami #SophieTurner https://t.co/0ypPKzZOcD pic.twitter.com/Rvq81wAlBH— Celebs Hot & Sexy Pics (@prettyhotsexy) August 4, 2019 Hot dusky #PriyankaChopra spotted in bikini on her vacation in #Miami pic.twitter.com/pDQYbGAjRs— Toxic Beauties (@toxicactress) August 4, 2019
Awami League central leaders on Saturday started their organisational tour to Khulna division, reports UNB.During the organisational tour, the central leaders will attend eight meetings (mostly extended special meetings) in Chuadanga, Jashore, Norail, Satkhira, Khulna, Bagerhat and Jhenaidah, said a press release.With the tour, the ruling party has started its organisational visit throughout the country ahead of the AL national council to be held in October 2019.On the first day of the tour, the AL leaders will join an extended special meeting of AL Chuadanga district unit on Saturday.AL district units will arrange seven meetings, while AL Khulna city unit will organise one meeting.The AL central leaders will attend the meetings in Jashore and Narail on Sunday, Satkhira on Monday.They will also join the meetings in Khulna city on 18 May, Khulna district on 19 May, Bagerhat on 20 May and Jhenaidah on 21 May.The members of the AL central organisational team formed for Khulna division include its presidium member Pijush Kanti Bhattacharya, acting general secretary Mahbubul Alam Hanif MP, joint general secretary Abdur Rahman, organising secretary Abu Sayeed Al Mahmud Swapan, labour affairs secretary Habibur Rahman Siraj, central working committee members Monnujan Sufian, MP, SM Kamal Hossain, lawyer Amirul Islam Milon and Parvin Zaman Kalpana.
Share Captain Kenneth Campbell, of HPD’s Traffic Enforcement Division (center), speaks at a media briefing on DWI enforcement during the 4th of July enforcement period that was held at HPD’s headquarters on July 3rd, 2018.The Houston Police Department (HPD) is urging Houstonians and visitors to have a plan to return safely to their homes or hotels after they attend Fourth of July celebrations on Wednesday.Captain Kenneth Campbell, of HPD’s Traffic Enforcement Division, noted during a media briefing held Tuesday that both taxi cabs, as well as driving services such as Uber and Lyft, are good options to make such plans. Having a designated driver is also a good alternative.“Go ahead and have that plan because we don’t want you to become a statistic and be in a fatal crash and we don’t want you to create a statistic by becoming another DWI arrested individual within our city,” emphasized Campbell, who noted that in 2017 during the Fourth of July “enforcement period”, HPD worked on more than nine fatality crashes and made more than 250 DWI arrests, 65 of which involved a crash.Sean Teare, chief of the Vehicular Crimes Division at the Harris County District Attorney’s Office, underlined on his part that being involved in a DWI has serious consequences, such as having to pay thousands of dollars in fines and losing your driver’s license, as well as having a conviction on your record.At a state level, the Texas Department of Public Safety (DPS) on Tuesday stepped up patrols with troopers on the lookout for intoxicated drivers, vehicles speeding, failure to use seat belts and other violations. Texas law requires everyone in a vehicle to buckle up.During the Fourth of July enforcement period in 2017, Texas troopers issued more than 98,000 tickets and warnings, including 1,658 seat belt and child safety restraint citations.HPD, @AAATexas Remind Motorists Don’t Get “Popped” on July 4th for DWI https://t.co/fvOObnz2cD— Houston Police (@houstonpolice) July 3, 2018
To embed this piece of audio in your site, please use this code: Houston’s small businesses took out more than $1.05 billion in loans through the Small Business Administration in fiscal year 2018, which ended September 30.But, Tim Jeffcoat, district director for the SBA in Houston, called it “a disappointing record year.”While the overall dollar amount went up, the number of small businesses that received loans shrank. Jeffcoat attributed this in part to the flooding from Harvey suppressing small business growth.“That tends to have more of an effect on the smaller businesses than it does on medium-size and large businesses,” he said.Larger businesses are more likely to have risk insurance, Jeffcoat said, which helps them recover more quickly.Separate from the 2018 loans, small businesses were also granted more than $455 million in emergency loans after Harvey. 00:00 /00:47 X Florian Martin/Houston Public MediaMany small businesses were flooded by Harvey, like those in the Deerbrook Marketplace strip mall in Humble. Listen Share
Explore further Potential therapeutic target for Parkinson’s disease (Phys.org)—A team of researchers at Stanford University has used ultrafast x-ray absorption and emission spectroscopy to quantify the entatic state of cytochrome c. In their paper published in the journal Science, the group outlines their procedure and what they learned. Kara Bren and Emma Raven with the University of Rochester and University of Leicester respectively offer a Perspective piece on the work done by the team in the same journal issue, and outline some of the implications regarding the role that the protein plays in cell life and death. More information: Metalloprotein entatic control of ligand-metal bonds quantified by ultrafast x-ray spectroscopy, Science (2017). science.sciencemag.org/cgi/doi … 1126/science.aam6203AbstractThe multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and apoptosis, switching function by modulating bonding between a heme iron and the sulfur in a methionine residue. This Fe–S(Met) bond is too weak to persist in the absence of protein constraints. We ruptured the bond in ferrous cyt c using an optical laser pulse and monitored the bond reformation within the protein active site using ultrafast x-ray pulses from an x-ray free-electron laser, determining that the Fe–S(Met) bond enthalpy is ~4 kcal/mol stronger than in the absence of protein constraints. The 4 kcal/mol is comparable with calculations of stabilization effects in other systems, demonstrating how biological systems use an entatic state for modest yet accessible energetics to modulate chemical function. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org Citation: Energetic cost of the entatic state of cytochrome c quantified (2017, June 23) retrieved 18 August 2019 from https://phys.org/news/2017-06-energetic-entatic-state-cytochrome-quantified.html A change in the active-site conformation turns cytochrome c from an electron shuttle in respiration to a peroxidase enzyme for apoptosis. Credit: (c) Science 23 Jun 2017: Vol. 356, Issue 6344, pp. 1236 , DOI: 10.1126/science.aan5587 Journal information: Science Cytochrome c is a protein that exists in many plants, animals and unicellular organisms. In humans, its main purposes are ferrying electrons in mitochondria and assisting with apoptosis (normal cell death and the processes surrounding it.) These two functions have been shown in prior efforts to rely on the position of methionine residue. When sulfur works with iron, the protein is ready to transfer electrons. Otherwise, it engages in peroxidase activities. In this new effort, the researchers sought to better understand the energetics of the protein by probing the iron and sulfur bond. Entatic states, Bren and Raven point out, are very important in bioinorganic chemistry—it actually translates to something that is stretched when subjected to tension.To better understand the bond between the two elements, the researchers temporarily forced them apart using a Linac Coherent Light Source X-ray free electron laser and then timed how long it took the two components to reform using iron X-ray emission spectroscopy. They found that the environment in which they existed boosted bond strength by four kilocalories per mole, which was enough to allow the protein to toggle between its functional states and to quantify the energy cost of the entatic state.As Bren and Raven note, the results of the study have implications regarding the role that cytochrome plays in respiration, which they relate to living and apoptosis, which they relate to death. To promote continued living the protein helps to maintain a certain reduction potential. For apoptosis, the entatic state is disrupted allowing peroxidase activity to be enhanced.